Dermatomiositis y queratodermia poroqueratósica punctata como síndrome paraneoplásico de un carcinoma ovárico

Valverde, R.; Sánchez-Caminero, M.P.; Calzado, L.; Frutos, F.J. Ortiz de; Rodríguez‐Peralto, José Luis; Vanaclocha, F.

doi:10.1016/s0001-7310(07)70082-0

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…Some authors suggest screening for underlying malignancies in cases of a PPK diagnosis. 2,7 Further studies are needed to determine whether this finding is a real association or a casual occurrence. …”

Section: Discussionmentioning

confidence: 99%

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Unilateral punctate porokeratosis - Case report

Teixeira

Reis

Vieira

et al. 2013

An. Bras. Dermatol.

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This case report involves a 20-year-old man with unilateral punctate porokeratosis. The patient presented an 8-year history of numerous asymptomatic keratotic papules and pits with linear distribution on his left pal-mar surface and fifth finger of the left hand. Histopathological examination of the keratotic plug revealed findings of distinct epidermal depressions containing cornoid lamellae. This report review draws attention to differential diagnoses of punctate porokeratosis.

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Section: Discussionmentioning

confidence: 99%

“…A cornoid lamella is sometimes observed when associated to a variety of inflammatory, hyperplastic and neoplastic dermatoses, thus not specific for porokeratosis. 7 …”

Section: Discussionmentioning

confidence: 99%

Unilateral punctate porokeratosis - Case report

Teixeira

Reis

Vieira

et al. 2013

An. Bras. Dermatol.

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“…Increasingly, NACT has been applied to those presenting with even more advanced disease, and noninferiority trials have justified such use when optimal surgical cytoreduction is not achievable, or there are compelling medical reasons for not proceeding with primary surgical cytoreduction [ 6 ]. Ovarian cancer can be associated with dermatomyositis as a paraneoplastic manifestation [ 7 ], and a diagnosis of dermatomyositis should prompt workup for such an occult malignancy.…”

Section: Discussionmentioning

confidence: 99%

Lasting pathologic complete response to chemotherapy for ovarian cancer after receiving antimalarials for dermatomyositis

Cadena

Werth

et al. 2018

ecancer

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Could hydroxychloroquine and quinacrine antimalarial therapy for dermatomyositis later attributed to a paraneoplasic manifestation of an ovarian cancer enhance its subsequent response to chemotherapy? Five months after being diagnosed with dermatomyositis, while somewhat improved with hydroxychloroquine, quinacrine and methotrexate, this 63-year-old woman presented with an advanced intra-abdominal epithelial ovarian cancer documented (but not resected) at laparotomy. Neoadjuvant carboplatin/paclitaxel resulted in remarkable improvement of symptoms, tumour markers and imaging findings leading to thorough cytoreductive surgery at completion of five cycles. No tumour was found in the resected omentum, gynaecologic organs, as well as hepatic and nodal sampling thus documenting a complete pathologic response; a subcutaneous port and an intraperitoneal (IP) catheter were placed for two cycles of IP cisplatin consolidation. She remains free of disease 3 years after such treatment and her dermatomyositis is in remission in the absence of any treatment. We discuss a possible role of autophagy in promoting tumour cell survival and chemoresistance that is potentially reversed by antimalarial drugs. Thus, chemotherapy following their use may subsequently lead to dramatic potentiation of anticancer treatment.

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