Dermatology: the last 30 years – a rollercoaster ride

Greaves, Malcolm W.

doi:10.7861/clinmedicine.9-6-588

Cited by 1 publication

(2 citation statements)

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“…Hence, some forms of chronic idiopathic urticaria came to be referred to as chronic autoimmune urticaria [15,[18][19][20][21]. There has also been an association between certain autoimmune disease and autoimmune urticaria, especially thyroid disease [25,26].…”

Section: Discussionmentioning

confidence: 99%

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Intravenous Immunoglobulin as a Potential Therapy for Refractory Urticaria - A Review

Watkins¹,

Peiris²,

Saleh³

et al. 2012

IADT

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Urticaria can be a chronic and debilitating affliction and is a relatively common disorder affecting between 10- 20% of the population. Common causes include reactions to medication, food allergen, physical stimuli and venoms. Urticaria can be acute or chronic. Chronic urticaria lasts for more than 6 weeks and is commonly difficult to treat. The use of immunosuppressive agents for this disorder when antihistamines fail can result in significant morbidity. Recent advances in the pathogenesis, etiology, diagnosis and management of chronic urticaria have led to new paradigms in treatment of this disorder. Cyclosporine is often the most effective but has some unique adverse effects that may prevent it from being used in some patients. The use of intravenous immunoglobulin (IVIG) has proven effective in a variety of reports and we will review the mechanisms likely involved in the successful control of urticarial symptoms by immunomodulating therapy using IVIG. In this review, we will discuss mechanisms and pathogenesis of urticaria and the specific role of intravenous immunoglobulin (IVIG) in this disorder, especially in refractory or steroid-dependent cases.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, physical triggers including pressure, heat, cold, exercise are well established causes of urticaria [14][15][16]. Hormones [17] and medications such as salicyclates have been indicated as well as autoimmunity [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%