Dermatologists' Accuracy in Early Diagnosis of Melanoma of the Nail Matrix

Chiacchio, Nilton Di; Hirata, Sérgio Henrique; Enokihara, Mauro Yoshiaki; Michalany, Nílceo Schwery; Fabbrocini, Gabriella; Tosti, Antonella

doi:10.1001/archdermatol.2010.27

Cited by 61 publications

(52 citation statements)

References 14 publications

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“…3,12,13 Its value in the differential diagnosis of nail melanoma has not been established. 6,14,15 Our results show that intraoperative dermatoscopy provides useful information for the differential diagnosis of LM. Removing the nail plate is a simple procedure.…”

Section: Discussionmentioning

confidence: 62%

Patterns of nail matrix and bed of longitudinal melanonychia by intraoperative dermatoscopy

Hirata

Yamada

Enokihara

et al. 2011

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 62%

Patterns of nail matrix and bed of longitudinal melanonychia by intraoperative dermatoscopy

Hirata

Yamada

Enokihara

et al. 2011

Journal of the American Academy of Dermatology

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“…Although melanocytic activation is the most common cause of LM in pigmented individuals who frequently have benign racial melanonychia involving multiple digits [2][3][4], melanocytic proliferation raises more concerns because LM may indicate an early stage of nail apparatus melanoma. The differential diagnosis to tell whether melanoma is the causative factor of LM remains an important task for dermatologists [5].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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Background: Longitudinal melanonychia (LM) may occur as a result of nail apparatus melanoma. Knowledge of etiology plays an important role in the management of LM. Objectives: The study is aimed to compare the diagnosis of LM in different age groups. Methods: We collected 63 cases (45 adults and 18 children) with LM who underwent nail matrix biopsy or excision in a 21-year cohort and assessed their clinicopathological features. Results: Melanomas in adults and children were 40% and none, while nevi accounted for 15.6% in adults and 94.4% in children. There was a statistically significant difference between the average age at diagnosis for melanoma (54.5 ± 13.3 years) and nevus (15.2 ± 18.5 years). Logistic regression related the occurrence of melanoma to older ages with a relative risk of 1.2 compared to nevus, but no cutoffs between age groups could be deﬁned between LM-associated nevus and melanoma. Conclusion: The adult group has a significantly higher risk of melanoma, while children with LM show mostly nonmelanoma etiologies. Tissue proof is more warranted in adult cases, and it is needed in selected cases of children with LM.

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“…For a series of skin neoplasms, κ ranged roughly between 0.54 and 0.64 [11]. Interobserver agreement on clinical findings for in situ nail matrix melanoma was approximately 0.7 for experts and 0.62 for seniors [10]. Ginarte et al [12] evaluated dermatological clinical signs in a similar way as we did.…”

Section: Discussionmentioning

confidence: 67%

“…mSWAT) may be based, to our knowledge, this issue has not been addressed in previous studies. Surprisingly, a brief review of the literature suggests that interdermatologist agreement about the clinical diagnosis of neoplastic diseases usually does not exceed a moderate range [10,11], and it is even lower when clinical signs are compared [12]. In fact, additional techniques have been proposed in order to improve the accuracy of staging for skin lesions in MF [3,13,14].…”

Section: Introductionmentioning

confidence: 99%

Does the New Staging System Proposed for Mycosis Fungoides and Sézary Syndrome Provide Reliable Agreement for T1 and T2 Disease?

Fernández-de-Misa

Machín²,

Aguirre‐Jaime

et al. 2014

Dermatology

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Background: Patch or plaque stages in mycosis fungoides (MF) have different prognoses. The recent staging system proposed for MF discriminates between patches and plaques based upon clinical features. Objective: To estimate interdermatologist agreement on the morphological evaluation of MF lesions. Methods: Twenty-four patients with MF were enrolled. Two dermatologists evaluated every lesion face to face and independently with respect to the patch-plaque status. Cohen's κ was used to determine the rate of agreement. Results: Agreement was 67% with respect to the patch or plaque status [95% confidence interval (CI) = 49-85%; p < 0.001]. Current systemic treatment (56%; p = 0.01) was associated with lower agreement. Younger age at diagnosis [odds ratio (OR) 1.03 (95% CI 1.02-1.05)], younger age at enrolment [OR 1.03 (95% CI 1.02-1.04)] and time on systemic treatment [OR 1.02 (95% CI 1.01-1.04)] were independent risk factors for disagreement (p < 0.001). Conclusion: The new system for MF staging carries a significant risk of disagreement regarding patch and plaque subsets.

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Dermatologists' Accuracy in Early Diagnosis of Melanoma of the Nail Matrix

Cited by 61 publications

References 14 publications

Patterns of nail matrix and bed of longitudinal melanonychia by intraoperative dermatoscopy

Patterns of nail matrix and bed of longitudinal melanonychia by intraoperative dermatoscopy

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Does the New Staging System Proposed for Mycosis Fungoides and Sézary Syndrome Provide Reliable Agreement for T1 and T2 Disease?

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