“…Presence of an endotracheal tube and prolonged intubation -paralysis, paresis, vocal cord atrophy, laryngeal oedema, dysphagia, arytenoid cartilage injuries, upper airway obstruction [25,26] Presence of a tracheostomy tube -paralysis, paresis, vocal cord atrophy, laryngeal oedema, dysphagia, arytenoid cartilage injuries, upper airway obstruction [25,26], tracheal stenosis [25] -stoma opening infection, wound breakdown and granulation, uncoordinated glottal closure and mechanical airflow, vocal cord tremor, dysphonia [26] -glottic and laryngeal stenosis, tracheomalacia, recurrent infections [25] Other -exertional dyspnoea, impaired respiratory function [25] Cardiovascular system Arterial line -limb ischaemia due to embolism, less commonly pseudoaneurysms -scarring, numbness, neuropathic pain, and local tenderness of the limb [34] Venous catheter (CVC) -vasoconstriction and/or thrombosis, limb swelling, difficulty in further cannulation [30] Related to vasoactive treatment -arrhythmias, myocardial ischemia, metabolic disorders (e.g. hyperglycaemia), ischemia of distal body parts (most often fingers and toes), leading to necrosis and the need for amputation of parts or entire fingers/limbs [35,36] Post-critical illness cardiovascular disease (PICD) -hyperlipidaemia, hypertension, diabetes, coronary artery disease, cerebrovascular disease, heart failure, chronic kidney disease [27,28,38,39] Other -tissue remodeling in the parenchymal vascular bed, heart, kidney, vascular dysfunction, heart, atherosclerosis [27] Gastrointestinal system -difficulty in food intake and weight loss [39] -intestinal obstruction and malabsorption syndrome, change in taste, nausea, food aversion, anorexia [25] Genitourinary system -acute renal failure and risk of developing chronic renal failure and death [31,40] -tissue remodeling in the parenchymal vascular beds of kidney [29] -sexual dysfunctions [41] Musculoskeletal system -contractures, most commonly in elbows, ankles, knees, and hips; limitations in movement and activity [25] -risk of higher mortality, cause of irreversible disability [42] Skin -reduced skin perfusion [32,43] -limited hydration and maceration cause of susceptibility to damage [32,…”