Dermatological indicators of coronary risk: a case-control study

Mirić, Dinko; Fabijanić, Damir; Giunio, Lovel; Eterović, Davor; Čulić, Viktor; Božić, Ivo; Hozo, Ismet

doi:10.1016/s0167-5273(98)00313-1

Cited by 53 publications

(44 citation statements)

References 12 publications

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“…However, controversial results can be identified in the literature, especially associating temporal pattern alopecia and CAD. 4,15 The present study did not identify any alopecia pattern as indicative of CAD.…”

Section: Discussioncontrasting

confidence: 77%

“…However, the multivariate analysis showed ELC as an isolated factor for CAD. 4,5 The choice of only male patients was based on the attempt of reducing the possibility of detect- The 2.5:1 ratio between cases and controls was determined to reduce the possibility of random error, considering the difficulty of having adult patients with normal exams in an observational study such as this one.…”

Section: Discussionmentioning

confidence: 99%

“…2 Historically, several dermatologic findings were described as CAD indicators, such as androgenetic alopecia, auricular hairiness, thoracic hairiness and the presence of diagonal earlobe crease (ELC), or Frank's sign ( Figure 1). 3,4 However, the literature contains few controlled studies assessing these associations. These dermatologic findings have not yet been systematically investigated in the Brazilian population.…”

Section: Introductionmentioning

confidence: 99%

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Associação entre doença arterial coronariana e as pregas lobular diagonal e anterotragal em homens

Miot

Medeiros

Siqueira

et al. 2006

An. Bras. Dermatol.

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Clinical, Epidemiological, Laboratory and Therapeutic InvestigationAbstract: BACKGROUND -Several dermatologic findings have been associated with coronary artery disease and represent easily visualized signs that may contribute to classify cardiac risk by a non-invasive technique. OBJECTIVES -To evaluate the prevalence of some dermatologic findings in patients with or without coronary artery disease. METHODS -A case-control study involving male patients submitted to coronary angiography was performed. We included patients with greater than 50% obstruction of at least one coronary artery. Both groups were assessed as to presence of diagonal earlobe crease and preauricular crease, alopecia and thoracic hairiness. The results were adjusted for known cardiac risk factors: age, body mass index, diabetes, hypertension, dyslipidemia and smoking. RESULTS -One hundred and ten individuals were evaluated (80 patients, 30 controls). The prevalence of diagonal earlobe crease in patients (60%) was greater than controls (30%) (p<0.05). Androgenetic alopecia and thoracic hairiness were not associated to coronary artery disease. The odds ratio for diagonal earlobe crease was 3.1 (1.2-8.3) and for preauricular crease was 5.5 (1.9-16.3). The simultaneous finding of diagonal earlobe crease and preauricular crease resulted in a positive predictive value of 90.0%. CONCLUSIONS -The study detected a positive association between bilateral diagonal earlobe crease and bilateral preauricular crease with coronary artery disease. The simultaneous finding of both folds had high predictivity for coronary artery disease. Keywords: Coronary arteriosclerosis; Ear, external; Male; Risk factors de 3,1 (1,2-8,3) e para prega anterotragal foi de 5,5 (1,9-16,3 Resumo: FUNDAMENTOS -Diversas alterações dermatológicas foram associadas à doença arterial coronariana

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associação entre doença arterial coronariana e as pregas lobular diagonal e anterotragal em homens

Miot

Medeiros

Siqueira

et al. 2006

An. Bras. Dermatol.

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“…Our findings also supported these observations and detailed them. Afterwards, subsequent studies with various sample sizes were performed in different patient populations including CAD, myocardial infarction in black or white men or women (5)(6)(7)(8)(9)(10)(11). Several of these reports also showed association between premature hair whitening and myocardial infarction, although many are relatively outdated and have some methodological limitations, especially in determining the extent of CAD and intensity of hair whitening.…”

Section: Discussionmentioning

confidence: 99%

The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age

Kocaman

Çetin²,

Durakoğlugil³

et al. 2012

Anadolu Kardiyol Derg

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The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological ageKoroner arter hastalığı için bağımsız bir risk öngörücüsü olarak saçın erken beyazlama düzeyi: Zamansal yaştan çok biyolojik yaşın öngörücüsü ABSTRACTObjective: Age is the most important and uncorrectable coronary risk factor at the moment. The concept of measuring aging biologically rather than only chronologically may be of importance in clinical practice. Hair graying is the most apparent sign of biological aging in humans, yet its mechanism is largely unknown. Today, it is known that cardiovascular risk factors (CVRFs), especially in combination, cause premature atherosclerosis. In our opinion, premature hair graying or whitening may represent early atherosclerotic changes as a surrogate of host response to the CVRFs. In this study, we planned to investigate the relationship of hair graying with CVRFs and coronary atherosclerotic burden in order to determine whether it is an independent marker for coronary artery disease (CAD). Methods: The current study has a cross-sectional observational design. Two hundred and thirteen men who underwent coronary angiography with a suspicion of CAD were enrolled in the study. The patients were evaluated in terms of age, demographical properties and the CVRFs. Hair whitening score (HWS) was defined according to extent of gray/white hairs (1: pure black; 2: black>white; 3: black=white; 4: white>black; 5: pure white). Coronary atherosclerotic burden was assessed by the Gensini score. Analyses were performed in age-matched normal coronary arteries (NCA) and CAD groups. Linear and logistic regression analyses were used for the multivariate analyses of independent variables associated with hair greying. Results: The CVRFs were higher in CAD group. Hair whitening score (2.7±1.3 vs. 3.3±1.2, p=0.002), hair losing score (1.2±0.9 vs. 1.5±1.0, p=0.038) and xanthelasma rate (24% vs. 45%, p=0.013) were also significantly different between NCA and CAD groups. Age (p<0001), Gensini score (p<0.001) and coronary severity score (p=0.001) were higher in the categories of increased HWS. In multiple logistic regression analysis, only diabetes mellitus (OR: 3.240, 95% CI: [1.017-10.319], p=0.047), low-density lipoprotein cholesterol, (OR: 1.014, 95%CI: [1.001-1.027], p=0.029) and HWS (OR: 1.513, 95% CI: [1.054-2.173], p=0.025) were independently related to presence of CAD. Age (p<0.001), family history of CAD (p=0.004), hyperlipidemia (p=0.02) and serum creatinine levels (p=0.019) were found as independent predictors of hair graying. Conclusion: In our study, we found that the degree of gray/white hairs is related to extent of CAD. Our findings also suggested that hair graying is a risk marker for CAD independent of age and other traditional risk factors. Biological age may be important in determining total risk of patients. During assessment of cumulative CVRF effects on human body, presence of biological aging signs may be useful in identi...

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“…In this issue, androgenetic alopecia, as a manifestation of androgenetic activity in the body, has been surveyed as a risk factor/ associated feature of clinical (ischemic heart disease) or subclinical (increased IMT) form of atherosclerosis [5][6][7][8][9][10][11]. Such relationship has been surveyed in many studies in which some studies approved the relationship [12][13][14][15], but the other did not [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%