Dermatological Indications and Usage of Topical Corticosteroid

Thomas, Jayakar; Prabhash, Kumar

doi:10.1007/978-981-10-4609-4_3

Cited by 4 publications

(3 citation statements)

References 80 publications

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“…It is a simple and safe treatment when used with caution. Intralesional steroid injections are better discontinued in patients showing side effects or those who do not show any signs of repigmentation in 2 months’ time 5 …”

Section: Discussionmentioning

confidence: 99%

“…Intralesional steroid injections are better discontinued in patients showing side effects or those who do not show any signs of repigmentation in 2 months' time. 5 NB-UVB is considered by many dermatologists as the treatment of choice for vitiligo because it delivers the largest amounts of the most beneficial wavelengths of UV light while minimizing the potentially harmful wavelengths. 12 To the best of our knowledge, the present study was the first to compare different concentrations of intralesional triamcinolone acetonide injections to determine the most effective one In the present study, we observed that patch 1 (injected with saline) revealed improvement in 40% of cases with a varying degree of response; the repigmentation achieved in this group may be attributed mainly to the effect of NB-UVB.…”

Section: Discussionmentioning

confidence: 99%

“…4 Intralesional steroid (ILS) injection is a simple and safe treatment when used with caution. 5 In addition, ILS injections have been studied and found to be useful, with repigmentation observed in as early as 3 weeks with very little side effects, when combined with narrowband ultraviolet B (NB-UVB).…”

Section: Introductionmentioning

confidence: 99%

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The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation

et al. 2021

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Background Treatment of vitiligo with intralesional steroid (ILS) injections has shown to be successful in quite a few studies. It is a simple and safe treatment when used with caution with a better response in localized lesions. ObjectivesThe aim of the present study is to explore the efficacy and safety of using different concentrations of intralesional corticosteroid combined with NB-UVB phototherapy in the treatment of non-segmental vitiligo (NSV) patients.Methodology Twenty patients with non-segmental vitiligo were subjected to different concentrations of ILS injections (triamcinolone acetonide); that was carried out monthly for six sessions. All patients were also subjected to twice-weekly sessions of NB-UVB for 6 months. Punch biopsy was taken from each patch before and at the end of treatment sessions. Each biopsy was stained with hematoxylin and eosin (H&E), Orcein, and Masson's trichrome stains. ResultsThere was a significant difference between all groups in their repigmentation response (P = 0.017). After treatment, the epidermal thickness (histometry) was decreased (epidermal atrophy), especially with concentrations of 2.5 and 5 mg/ml of intralesional triamcinolone acetonide injection with decreased and disorganized collagen fibers. ConclusionIntralesional corticosteroid injections combined with NB-UVB showed a good and well-tolerated therapeutic option for vitiligo. The concentrations of 0.625 and 1.25 mg/ml of triamcinolone acetonide were the safest with fewer side effects and complications. However, higher concentrations of 2.5 and 5 mg/ml were more effective but with more side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation

et al. 2021

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Level of Awareness and Attitude towards Topical Steroids among Medical Interns

Agarwal¹,

Suganita²,

Mittal³

et al. 2020

jemds

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Topical treatment of psoriasis

Baranová¹

2018

Dermatol. praxi

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Článok poskytuje prehľad súčasných možností lokálnej liečby psoriázy. Hoci je dnes k dispozícii široká škála lokálnych a systémových liečebných postupov, žiadna liečba psoriázy nie je univerzálne účinná pre každého pacienta. Jej výber závisí od umiestnenia lézií, ich veľkosti, od rozsahu postihnutej kože a predchádzajúcej terapeutickej odpovede i preferenciách liečby. Topické liečebné postupy zahŕňajú emolienciá, keratolytiká, decht, antralín, lokálne kortikosteroidy, lokálny vitamín D3, tazarotén. Lokálne prostriedky sú často pomerne lacné a účinné a majú veľmi dobrý bezpečnostný profil. Preto sú pacienti s miernou až stredne ťažkou psoriázou najprv liečení lokálne. Veľa psoriatických pacientov s nimi dokáže ostať v dlhodobej remisii, znížujú exacerbácie psoriázy a zlepšujú kvalitu života. Kombinácia viacerých terapií vedie k maximalizácii prínosu a zníženiu vedľajších účinkov. Dermatológovia by mali individualizovať liečebný režim pre každého psoriatického pacienta.

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Dermatological Indications and Usage of Topical Corticosteroid

Cited by 4 publications

References 80 publications

The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation

The use of intralesional corticosteroid combined with narrowband ultraviolet B in vitiligo treatment: clinical, histopathologic, and histometric evaluation

Level of Awareness and Attitude towards Topical Steroids among Medical Interns

Topical treatment of psoriasis

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