Dermatologic drug reactions

McKENNA, Jeffrey K.; Leiferman, Kristin M.

doi:10.1016/j.iac.2004.03.007

Cited by 57 publications

(40 citation statements)

References 62 publications

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“…Skin reactions as a result of non-immunological causes are more common and include cumulative toxicity, overdose, photosensitivity, drug interactions, and metabolic alterations. [9]Many commonly used drugs can produce serious cutaneous ADRs which can lead to morbidity and some may even prove lethal. The high incidence of ADRs, poor ADR reporting, meager data on the ADR profile, probability, severity and causality assessment makes it difficult to ensure safety of drug usage.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions-A Study of Clinical Patterns, Causality, Severity & Preventability

Verma¹,

Tiwari²,

Gupta³

et al. 2014

IOSRJDMS

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Section: Introductionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions-A Study of Clinical Patterns, Causality, Severity & Preventability

Verma¹,

Tiwari²,

Gupta³

et al. 2014

IOSRJDMS

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“…More severe forms of cutaneous drug reactions include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis and exfoliative dermatitis. These are life-threatening conditions if they are not treated (18,19). In drug allergies of hospitalized patients, cutenous rash has been observed with a rate of 96% and systemic symptoms have been observed with a rate of 30%.…”

Section: Clinical Findings In Drug Allergiesmentioning

confidence: 99%

Çocuklarda ilaç alerjileri

...

2012

Tpa

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Review Sum maryDrug allergy when compared with other allergic diseases can be the cause of very serious reactions and can be life-threatening if neglected. In clinical practice, a wide range of symptoms from mild urticaria to anaphylaxis can be observed so that it can mimic the symptoms of all other allergic diseases. One of the significant consequences of allergic drug reactions is the use of less effective, more expensive or more toxic drugs in the future. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Confirmatory tests, if avaliable, should be used to determine the allergic status of the patient. If these tests are not avaliable, depending on the type of clinical reaction previously demonstrated, a graded challenge or desensitization may be considered. Education of the patient and primary care physician is an important component of management. (Turk Arch Ped 2012; 47: 86-91)

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“…Particular care is needed in patients with unusual skin rashes, neurological or muscular illnesses, but the list of known and suspected conditions caused by medication is very long [1], and nobody can expect to remember them all. While a balance needs to be struck between ignoring the possibility and extreme paranoia about drug reactions, it remains true to say that only by considering the possibility will the correct diagnosis be reached.…”

Section: Patient Presenting With a Rash Or Other Plausible Adverse Eventmentioning

confidence: 99%

General principles of investigating and managing drug allergy

Frew

2011

Brit J Clinical Pharma

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Adverse reactions to medication are common. Some are predictable side-effects of the drug, others involve individual sensitivity to the drug. Allergic reactions are an important subset of these, but other specific sensitivities are caused by variations in the metabolism or mode of action of the drug. Patients who have experienced adverse reactions to medication will often refer to themselves as being allergic to the drug, regardless of the actual mechanism that caused the reaction. Consequently, anyone taking a history of 'drug allergy' needs to keep an open mind about the mechanism that may have been involved. Fortunately, most idiosyncratic reactions are minor, but some are severe, or even life-threatening. In most situations, there are satisfactory alternatives for the drug in question, but sometimes it is necessary to investigate and get an accurate diagnosis. The over-riding priority is to distinguish anaphylactic, potentially life-threatening reactions from other types of drug reaction, which are generally more protracted, less dangerous and usually managed by simple avoidance. While all doctors need to understand the underlying principles, drug challenges should only be undertaken by clinicians experienced in this area.

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Dermatologic drug reactions

Cited by 57 publications

References 62 publications

Cutaneous Adverse Drug Reactions-A Study of Clinical Patterns, Causality, Severity & Preventability

Cutaneous Adverse Drug Reactions-A Study of Clinical Patterns, Causality, Severity & Preventability

Çocuklarda ilaç alerjileri

General principles of investigating and managing drug allergy

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