Dermatoglyphics in von Recklinghausen neurofibromatosis

Abstract

We studied dermatoglyphic traits in 27 patients (12 males and 15 females) with neurofibromatosis type I (NF-1) to verify which characteristics may be considered typical of this disorder. The frequency of digital central pockets in the patients was significantly greater than in control individuals (P less than .005), but when we evaluated the sexes separately, the difference was significant only among females (P less than .002). The distribution of central pockets on the various fingers was significantly different in affected females, compared with normal controls, but only on fingers II (P less than .05), IV (P .002), and V (P less than .05). The quantitative finger tip pattern values and the total finger ridge count (TFRC) were always higher in the patients, as well as was the a-b ridge count. The latter was significantly increased only on the right hand in females (P less than .01). Among the patients, the atd angle values were increased on both hands of females and on the right hand in males, whereas both the ulnar index A'-d and the a-t' ridge counts were diminished. The frequency of high endings (5' or 5") of line A was increased in NF-1 patients on both hands. Like in previous investigations, our patients showed an increased number of secondary creases, limited to II degree according to Vormittag et al. [1986] (P less than .048). Our results only partially confirmed prior data. Therefore, we think that there is no typical dermatoglyphic pattern in NF-1 and that this parameter is not a diagnostic indicator in this disorder.

Occurrence of Dandy-Walker anomaly in a familial case of distal arthogryposis type IIB

“…The digital dermatoglyphic analysis in our patients is not concordant, the total finger ridge count (TFRC) being low in case 1 and high in cases 2 and 3, compared with the average count of 143.17 and 153.27 in females and males, respectively, in a population of southern Italy [Pallotta et al, 1989].…”

A patient defines the interstitial 1q deletion syndrome characterized by antithrombin III deficiency

“…Other ®ndings included ®fth ®nger clinodactyly, small hands and feet, bilateral inguinal hernia, bilateral transverse palmar crease, short stature, hypotonia, and psychomotor delay (Denver Developmental Screening test corresponding to 4 months). Dermatoglyphics showed a total ®nger ridge count of 47, a very low value when compared to the average count of 153.27 in a male population of Southern Italy [Pallotta et al, 1989].This feature was also present in the father. Cranial ultrasound, and brainstem auditory evoked potentials were normal.…”

Dermatoglifia de Pacientes Portadores de Neurofibromatose Tipo 1

“…Nessa mesma linha, outros autores observaram um aumento significativo de verticilos nos dedos II, IV e V apenas na mão direita de pacientes do sexo feminino 25 . Os dados relativos ao aumento da frequência de presilhas ulnares em pacientes de ambos os sexos em comparação com os controles, assim como os dados sobre verticilo em pacientes do sexo masculino, estão apenas parcialmente de acordo com o que foi observado anteriormente 25 .…”

“…Os dados relativos ao aumento da frequência de presilhas ulnares em pacientes de ambos os sexos em comparação com os controles, assim como os dados sobre verticilo em pacientes do sexo masculino, estão apenas parcialmente de acordo com o que foi observado anteriormente 25 . Pacientes com NF1 apresentam um aumento da prevalência de verticilos [20][21][22][23][24] .…”

“…Pacientes com NF1 apresentam um aumento da prevalência de verticilos [20][21][22][23][24] . Concluiu-se a partir daí que Entretanto, uma avaliação posterior 25 apenas confirmou parcialmente os achados relatados anteriormente. Embora um padrão dermatoglífico característico de NF1 não tenha sido determinado com precisão até o momento, seu estudo tem o potencial de contribuir para o diagnóstico precoce da doença.…”