Dermatofibrosarcoma protuberans of the hallux: A case report with review of the literature

Elafram, Rafik; Romdhane, Majdi Ben; Khessairi, Nayssem; Sghaier, Majdi; Annabi, Hassen El

doi:10.1016/j.ijscr.2022.107325

Cited by 3 publications

(7 citation statements)

References 29 publications

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“…Clinically, atrophic DFSP lesion is centrally depressed, whereas classical DFSP has a protuberant presentation; however, both variants show similar histological and immunohistochemical features, such as fibrohistocytic cell proliferation [ 14 , 15 ], CD34, and vimentin expression, and lack of staining with CD44, S100 protein or XIIIa [ 1 , 16 ]. Both variants also demonstrate COL1A1/PDGFB gene rearrangement fusion [ 2 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Histological margins are usually more extensive than clinical margins; hence wide local excision is generally considered a preferred treatment modality with a safety margin range from 3 to 5 cm, especially if the lesion is not in delicate areas such as the head and neck, where Mohs Micrographic Surgery (MMS) is preferred to avoid cosmetic side effects. Re-excision should be performed in case of recurrence [ 2 ]. Distant metastasis has been reported in 6% of patients despite multiple failed local surgery attempts [ 2 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor representing 1.8% of all soft tissue sarcomas [ 1 , 2 , 3 ]. The WHO classified DFSP as a low-grade sarcoma, owing to its locally aggressive behavior and low metastatic potential [ 2 , 4 ]. It primarily affects trunks and extremities and rarely involves other body sites [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The WHO classified DFSP as a low-grade sarcoma, owing to its locally aggressive behavior and low metastatic potential [ 2 , 4 ]. It primarily affects trunks and extremities and rarely involves other body sites [ 2 ]. This tumor has a higher propensity for women and the black population [ 2 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…This tumor has a higher propensity for women and the black population [ 2 , 5 , 6 ]. The most common clinical presentation of DFSP is a single, slow-growing, pinkish or brownish asymptomatic plaque-like area of cutaneous thickening or raised, nipple-like projection, which usually takes years to develop, causing latency in seeking medical attention, and delayed diagnosis [ 2 , 7 ]. The atrophic variant was first described by Lambert et al in 1985 [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Atrophic Dermatofibrosarcoma Protuberans with Eosinophilic Infiltration

et al. 2022

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Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive spindle cell mesenchymal tumor arising in the dermis, with low metastatic potential. The most commonly affected sites are the trunk and proximal extremities; rarely are acral sites involved. Atrophic DFSP is a rare form of DFSP, that is morphologically different but histologically similar to DFSP. It commonly affects young adults between the ages of 20 to 50 years. The current management strategy for atrophic DFSP is surgical excision with long-term follow-up to detect any recurrence. Only one known case of atrophic DFSP with eosinophilic infiltration is what makes our case an exceptionally rare presentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Atrophic Dermatofibrosarcoma Protuberans with Eosinophilic Infiltration

et al. 2022

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A challenging diagnosis of dermatofibrosarcoma protuberans of the middle finger in an infant: A case report

Hanna,

Alkhatib,

Alassri

et al. 2024

International Journal of Surgery Case Reports

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Huge hypertrophic scar secondary to chronic ingrown toe nail mimicking tumor: A case report

Ju,

Lee,

Kim

et al. 2024

Medicine

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Rationale: A huge hypertrophic scar formation secondary to chronic ingrown toe nail mimicking tumor is a rare disease. It is not only causing concerns cosmetically, but also hindering normal daily activities physically and socially. In this paper, we present an unusual case of bilateral ingrown nails with different phases. One resulted in a large hypertrophic scar caused by stimulation from secondary to chronic ingrown nail. Patient concerns and diagnosis: A 44-year-old man with a huge mass (7 × 4 × 8.5 cm) in his right great toe and inflamed ingrown nail in his left great toe visited the clinic. The mass in the right toe showed an irregular and bizarre shape with a stellate ulcer (2 × 2 cm) at the distal end. After removing an ingrown nail 3 years ago with minor repetitive trauma, self-managed wound has grown into a tumor-like mass, resulting in intolerable discomfort. In gross appearance, a stalk appeared to originate from the lateral side of the nail bed with the ingrown nail in the great toe showing inflamed medial and lateral gutter and causing redness and tenderness. Huge hypertrophic scar formation secondary to chronic ingrown toe nail mimicking tumor is a rare disease that is not only causing a cosmetic concern, but also hindering normal daily activities physically and socially. Intervention and outcomes: Excisional biopsy was performed for both great toes. Biopsy confirmed chronic ulcerative inflammation with a hypertrophic scar. The resection site healed and persisted well at 12 months after surgery. Conclusion: Our unusual case suggests that the natural course of an untreated ingrown toe nail may result in hypertrophic scar extending far to mimic tumorous conditions.

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Dermatofibrosarcoma protuberans of the hallux: A case report with review of the literature

Cited by 3 publications

References 29 publications

Atrophic Dermatofibrosarcoma Protuberans with Eosinophilic Infiltration

Atrophic Dermatofibrosarcoma Protuberans with Eosinophilic Infiltration

A challenging diagnosis of dermatofibrosarcoma protuberans of the middle finger in an infant: A case report

Huge hypertrophic scar secondary to chronic ingrown toe nail mimicking tumor: A case report

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