Dermatoendocrinology

Makrantonaki, Evgenia; Cc, Zouboulis

doi:10.1007/s00105-009-1889-8

Cited by 13 publications

(5 citation statements)

References 67 publications

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“…There is a natural senescence of the nervous system with aging [1, 2]. This has a direct impact on autonomic function that has been observed in a number of different ways.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Autonomic Dysfunction Associated with Aging and Type 2 Diabetes on Daily Life Activities

Petrofsky

Berk

Al-Nakhli

2012

Experimental Diabetes Research

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Type 2 diabetes (T2D) and ageing have well documented effects on every organ in the body. In T2D the autonomic nervous system is impaired due to damage to neurons, sensory receptors, synapses and the blood vessels. This paper will concentrate on how autonomic impairment alters normal daily activities. Impairments include the response of the blood vessels to heat, sweating, heat transfer, whole body heating, orthostatic intolerance, balance, and gait. Because diabetes is more prevalent in older individuals, the effects of ageing will be examined. Beginning with endothelial dysfunction, blood vessels have impairment in their ability to vasodilate. With this and synaptic damage, the autonomic nervous system cannot compensate for effectors such as pressure on and heating of the skin. This and reduced ability of the heart to respond to stress, reduces autonomic orthostatic compensation. Diminished sweating causes the skin and core temperature to be high during whole body heating. Impaired orthostatic tolerance, impaired vision and vestibular sensing, causes poor balance and impaired gait. Overall, people with T2D must be made aware and counseled relative to the potential consequence of these impairments.

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“…There is a natural senescence of the nervous system with aging [1, 2]. This has a direct impact on autonomic function that has been observed in a number of different ways.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Autonomic Dysfunction Associated with Aging and Type 2 Diabetes on Daily Life Activities

Petrofsky

Berk

Al-Nakhli

2012

Experimental Diabetes Research

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“…These ingredients are important for maintaining the skin's good elasticity. Therefore, the decline in endocrine system function is also one of the important factors affecting skin aging 58 . In addition, the adaptive ability of the skin's immune system decreases significantly with age, and the immune tissue aging, dysfunction, and cytopenia lead to the occurrence of skin infectious diseases, and the skin's resistance to external damage factors decreases 59,60 …”

Section: Mechanism Of Maintaining Skin Homeostasis Under Environmenta...mentioning

confidence: 99%

Skin homeostasis: Mechanism and influencing factors

Jiao,

Zhi,

You

et al. 2024

J of Cosmetic Dermatology

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BackgroundThe skin is the largest organ in the human body, not only resisting the invasion of harmful substances, but also preventing the loss of moisture and nutrients. Maintaining skin homeostasis is a prerequisite for the proper functioning of the body. Any damage to the skin can lead to a decrease in local homeostasis, such as ultraviolet radiation, seasonal changes, and air pollution, which can damage the skin tissue and affect the function of the skin barrier.ObjectiveThis article reviews the maintenance mechanism and influencing factors of skin homeostasis and the symptoms of homeostasis imbalance.MethodsWe searched for articles published between 1990 and 2022 in English and Chinese using PubMed, Web of Science, CNKI, and other databases in the subject area of dermatology, using the following search terms in various combinations: “skin homeostasis,” “skin barrier,” and “unstable skin.” Based on our results, we further refined our search criteria to include a series of common skin problems caused by the destruction of skin homeostasis and its treatments. Limitations include the lack of research on dermatological and cosmetic problems triggered by the disruption of skin homeostasis.ResultsThis study describes the neuroendocrine‐immune system, skin barrier structure, and skin metabolic system that maintain skin homeostasis. In addition, we discuss several common symptoms that occur when skin homeostasis is out of balance, such as dryness, redness, acne, sensitivity, and aging, and explain the mechanism of these symptoms.ConclusionThis article provides an update and review for students and practitioners, and provides a theoretical basis for the development of skin care products for the maintenance and repair of skin homeostasis.

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“…The hormonal milieu of the body also has dramatic effects on the skin dependent on the gender of its owner and the sequential hormone changes (i.e., growth hormones, sex-related hormones) to which it is exposed as its owner ages [85].…”

Section: Changes At the Genome Levelmentioning

confidence: 99%

Degenerative Changes in Aging Skin

Farage¹,

Miller²,

Maibach

2015

Textbook of Aging Skin

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Increased life spans have created a need for greater understanding of the diseases of old age including the integumentary systemthe skin. The skin is the largest organ of the human body and performs multiple functions , including homeostatic regulation; prevention of percutaneous loss of fluid, electrolytes, and proteins; temperature maintenance; sensory perception; and immune surveillance. Aging involves both internal aging processes and external stressors to produce consistent changes such as thinning, drying, wrinkling, and uneven pigmentation. Understanding the fundamental physiology of changes in the epidermis, dermis, and hypodermis provides a foundation for progress in understanding the dermatological needs of those whose skin is aging. Physiological changes in aged skin include changes in biochemistry, permeability, vascularization and thermoregulation, response to irritants, immune response, repair capacity and response to injury, and neurosensory perception as well as changes at the genome level. Although aging of the skin, like other systems, is inevitable, research is beginning to define ways to both delay and minimize the troublesome effects of aging on the skin.

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Dermatoendocrinology

Cited by 13 publications

References 67 publications

The Influence of Autonomic Dysfunction Associated with Aging and Type 2 Diabetes on Daily Life Activities

The Influence of Autonomic Dysfunction Associated with Aging and Type 2 Diabetes on Daily Life Activities

Skin homeostasis: Mechanism and influencing factors

Degenerative Changes in Aging Skin

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