Dermatitis caused by Olanedine (olanexidine gluconate) and povidone iodine

Matsuoka, Katsunari; Kumata, Sakiko; Watanabe, Risa; Yamada, Tetsu; Matsuoka, Takahisa; Nagai, Shinjiro; Ueda, Mitsuhiro; Miyamoto, Yoshihiro

doi:10.1111/cod.13178

Cited by 12 publications

(13 citation statements)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, allergic reaction to chlorhexidine has been reported [27,28], and because of the structural similarity to chlorhexidine, olanexidine gluconate can cause a similar allergic reaction. Cases of allergic contact dermatitis caused by olanexidine gluconate have been reported recently [29,30]. In the current study, we observed skin erythema in three patients and pruritis in two patients; however, these complaints were not completely consistent with the site of disinfection.…”

Section: Discussioncontrasting

confidence: 62%

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study

Yamamoto

Hara

Sugezawa

et al. 2020

Langenbecks Arch Surg

View full text Add to dashboard Cite

Purpose Olanexidine gluconate is a newly developed solution for skin disinfection that was recently approved in Japan. We aimed to compare single and double application of the solution in preventing surgical site infection (SSI) in patients undergoing general surgery. Methods This randomized study was conducted at the Tottori University Hospital. Patients scheduled to undergo gastrointestinal or hernia surgery were randomly assigned to one of two groups using either one or two Olanedine applicators for skin disinfection. The primary endpoint was the difference in SSI incidence between the two groups. The secondary endpoint was all adverse events related to olanexidine gluconate. Results A total of 393 patients qualified for the study protocol: 193 received a single application, and 200 received a double application of Olanedine. SSI occurred in 10 patients (2.5%) overall; nine were superficial incisional SSIs, and one patient had a deep incisional SSI. Of the 10 patients who developed SSI, six (3.1%) were in the group receiving a single application, and four (2.0%) were in the group receiving a double application; there was no statistically significant difference between the two groups (P = 0.537). Allergic reactions or skin disorders related to olanexidine gluconate were not observed. Conclusion There was no difference in the SSI incidence between the use of one or two Olanedine applicators for skin preparation in elective general surgery. Therefore, a single application of Olanedine is sufficient and is recommended for general surgery as a standard disinfection precaution. Trial registration number UMIN000027319; 5/12/2017.

show abstract

Section: Discussioncontrasting

confidence: 62%

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study

Yamamoto

Hara

Sugezawa

et al. 2020

Langenbecks Arch Surg

View full text Add to dashboard Cite

show abstract

“…Performing patch tests with ×2 and ×5 Olanedine solution using dried filter paper would have provided more evidence for a diagnosis of allergic contact dermatitis in the present case. On the other hand, in previous cases of allergic contact dermatitis due to Olanedine solution, 4,5 the patients were diagnosed on the basis of positive results in 48‐hour closed patch tests with ×1 Olanedine solution applied wet. These results might have been due to irritation because similar reactions also occurred in our healthy control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Nagai et al 4 reported two cases, in whom eruptions appeared at 10 and 6 days after an operation, respectively. Matsukoka et al 5 retrospectively compared the incidence of skin reactions to Olanedine solution with that of reactions to povidone iodine solution. As a result, they found that skin eruptions appeared more often in the group in which Olanedine solution was used (23/567 cases, 3.7%) than in the group in which povidone iodine solution was used (4/626 cases, 0.7%).…”

Section: Discussionmentioning

confidence: 99%

“…18472‐51‐0, C 22 H 30 Cl 2 N 10 •2C 6 H 12 O 7 , molecular weight 897.76). Several cases of allergic contact dermatitis caused by Olanedine solution were reported in 2018, in which the patients were diagnosed based on positive results being obtained in 2‐day closed patch tests of Olanedine solution “as is.” 4,5 However, we suspect that such 2‐day patch testing is not suitable for diagnosing patients with Olanedine‐induced allergic contact dermatitis because other antiseptics, such as 1% chlorhexidine gluconate and acetate 6 or 10% povidone‐iodine, 7,8 can induce strong irritant reactions during patch testing as well as during clinical use. Therefore, a dried filter paper technique 9 and a dilution method 10 were proposed as methods for differentiating allergic contact dermatitis caused by 10% povidone‐iodine from irritant contact dermatitis caused by 10% povidone‐iodine.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A case of allergic contact dermatitis caused by Olanedine solution—A diagnostic patch‐testing method involving dried filter paper

Iijima¹,

Matsunaga

2020

Contact Dermatitis

View full text Add to dashboard Cite

Background Olanedine solution is a new antiseptic, and several cases of allergic contact dermatitis caused by the agent were reported in 2018; however, these cases were diagnosed based on positive results in 2‐day closed patch testing of Olanedine solution “as is.” Objectives To present another case of Olanedine‐induced allergic contact dermatitis and to analyze the optimal patch‐testing method for this condition. Methods A 34‐year‐old Japanese female patient and 25 healthy control subjects were patch tested using wet filter paper, which had been treated with 15 μL Olanedine solution, and dried filter paper, which had been treated with 15 μL Olanedine solution and then dried. Results The patient and all of the control subjects exhibited false‐positive reactions due to irritation in the 2‐day closed patch tests with wet filter paper containing Olanedine solution “as is.” The tests with dried filter paper produced a positive reaction on day 7 in the patient, and negative reactions in all control subjects. Conclusions It is preferable to perform 2‐day closed patch tests using filter paper with the test solution “as is,” which had been dried before application in order to correctly diagnose antiseptic‐induced allergic contact dermatitis.

show abstract

“…The overall incidence of adverse events in OLG was very low, ranging from 2% to 5.8%. 26 , 52 , 56 , 57 , 59 , 60 , 61 Erythema, dermatitis, and pruritus each accounted for approximately 1.0%–1.9% of adverse events. 26 , 52 , 59 , 61 The time of appearance of skin rash was approximately 3–17 days (median, 7 days) after application 60 (Table 6 ).…”

Section: Resultsmentioning

confidence: 99%

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Shinzato

Sakihara

Kishihara

et al. 2022

Acute Medicine & Surgery

View full text Add to dashboard Cite

Surgical site infections (SSIs) and catheter‐related bloodstream infections (CRBSIs) caused by bacteria from surfaces poorly disinfected with chlorhexidine gluconate (CHG) and povidone‐iodine (PVP‐I) are increasing. Olanexidine gluconate (OLG) was developed in 2015 in Japan to prevent SSI and CRBSI caused by bacteria resistant to CHG and PVP‐I. This scoping review aimed to identify the knowledge gap between what is known and what is not known about the disinfection efficacy of OLG. We searched MEDLINE through PubMed, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the International Clinical Trials Registry Platform search database, ClinicalTrials.gov , and the Web‐based database of Japanese medical articles for works published to July 18, 2021. Manual reference searches were also carried out. A total of 131 studies were screened. Forty‐seven studies were included in this review and classified into two major categories: studies on pharmacological effects and spectrum ( n = 29) and studies on clinical and adverse effects ( n = 18). Olanexidine gluconate showed bactericidal activity against methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, in addition to common Gram‐positive and Gram‐negative bacteria. In clinical settings, although there is limited evidence on SSI prevention, 1.5% OLG might be more effective than 10% PVP‐I and 1% CHG in preventing SSI. However, the clinical usefulness of OLG is unclear due to the limited number of clinical studies. Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention.

show abstract

Dermatitis caused by Olanedine (olanexidine gluconate) and povidone iodine

Cited by 12 publications

References 4 publications

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study

A case of allergic contact dermatitis caused by Olanedine solution—A diagnostic patch‐testing method involving dried filter paper

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Contact Info

Product

Resources

About