Dermatan carriers for neovascular transport targeting, deep tumor penetration and improved therapy

Ranney, David F.; Antich, Peter P.; Dadey, Eric J.; Mason, Ralph P.; Kulkarni, P. V.; Singh, O. N.; Chen, Huagang; Constantanescu, Anca; Parkey, Robert W.

doi:10.1016/j.jconrel.2005.09.022

Cited by 30 publications

(18 citation statements)

References 36 publications

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“…Additionally, drugs that inhibit GAG synthesis have been used to reduce the thickness of the layer [11]. Alternatively, glycosaminoglycan drug carriers have been shown to be taken up into GAG layers, increasing penetration of drug into tumour interstitium [12,13]. GAG has also been considered a barrier to effective therapy with the immunotherapeutic drug BCG [14].…”

Section: Glycosaminoglycans Present a Barrier To Drug Penetrationmentioning

confidence: 99%

Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer

Heijden

Dewhirst

2016

International Journal of Hyperthermia

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Non-muscle-invasive bladder cancer is a challenging disease, even given its superficial nature. It is prone to multiple recurrences and progression to muscle-invasive cancer. These features of this disease contribute significantly to reduced quality of life as well as creating significant morbidity and even mortality. Randomised trials demonstrate that when hyperthermia is added to conventional mitomycin-C treatment that local control rates and progression-free survival are substantially improved. In this review we consider how hyperthermia can exert such beneficial effects. Some of the mechanisms presented are theoretical, while others are facts. It is hoped that this review will contribute rationale for further examination of mechanisms, because an understanding of such mechanisms may lead to even better chemotherapeutic approaches, as well as potential biomarkers for predicting and monitoring treatment success.ARTICLE HISTORY

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Section: Glycosaminoglycans Present a Barrier To Drug Penetrationmentioning

confidence: 99%

Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer

Heijden

Dewhirst

2016

International Journal of Hyperthermia

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“…It has been shown in certain cancer xenografts that the outer rim of the tumor is better perfused than the central region. 27,[38][39][40] Utilizing MRI and redox scanning, our melanoma studies demonstrated a distinct core-rim difference both for the blood transfer constant ͑K trans ͒ measured by dynamic contrast enhancement MRI ͑DCE-MRI͒ and the mitochondrial redox state measured by low-temperature NADH/Fp fluorescence. 27 The more aggressive melanoma line appears to have a tumor core with less blood perfusion, lower nutrient supply, and a more oxidized redox state.…”

Section: Possible Metabolic States In Tumorsmentioning

confidence: 99%

Quantitative mitochondrial redox imaging of breast cancer metastatic potential

et al. 2010

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Abstract. Predicting tumor metastatic potential remains a challenge in cancer research and clinical practice. Our goal was to identify novel biomarkers for differentiating human breast tumors with different metastatic potentials by imaging the in vivo mitochondrial redox states of tumor tissues. The more metastatic ͑aggressive͒ MDA-MB-231 and less metastatic ͑indolent͒ MCF-7 human breast cancer mouse xenografts were imaged with the low-temperature redox scanner to obtain multi-slice fluorescence images of reduced nicotinamide adenine dinucleotide ͑NADH͒ and oxidized flavoproteins ͑Fp͒. The nominal concentrations of NADH and Fp in tissue were measured using reference standards and used to calculate the Fp redox ratio, Fp/ ͑NADH+ Fp͒. We observed significant core-rim differences, with the core being more oxidized than the rim in all aggressive tumors but not in the indolent tumors. These results are consistent with our previous observations on human melanoma mouse xenografts, indicating that mitochondrial redox imaging potentially provides sensitive markers for distinguishing aggressive from indolent breast tumor xenografts. Mitochondrial redox imaging can be clinically implemented utilizing cryogenic biopsy specimens and is useful for drug development and for clinical diagnosis of breast cancer.

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“…5 Despite their potential as a targeted drug delivery system, nanoparticles made of PLG/PLA or mPEG-PLGA/ mPEG-PLA have limited capability for encapsulating water soluble drugs, including therapeutic peptides, due to the large surface area, hydrophobic nature of PLGA/PLA, their chemical properties, and methods of production. To overcome these shortcomings, various strategies have been developed, such as the use of drug complexation agents, 6 complexation with phospholipids, 7 and inclusion of ion-paring agents in the formulation, 8 all of which are designed to improve the incorporation of drug and peptide into these polymeric nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Effect of formulation factors on incorporation of the hydrophilic peptide dalargin into PLGA and mPEG‐PLGA nanoparticles

2008

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The objective of this study was to examine formulation factors that influence the incorporation of the hydrophilic peptide dalargin into poly(D, L-lactic-co-glycolic acid) (PLGA) and methoxy-polyethylene glycol (mPEG)-PLGA nanoparticles. In particular, the effect of ionic additives and nanoparticle method of preparation on the incorporation of dalargin and resultant nanoparticle properties was investigated. Biodegradable nanoparticles were prepared from mPEG-PLGA and PLGA by both solvent evaporation and solvent diffusion methods with inclusion of ionic additives of dextran sulphate (DS), sulfobutyl ether-beta-cyclodextrin (SB-CD), or sodium dodecyl sulfate (SDS). The resultant nanoparticles were analyzed for their mean particle size and size distribution, zeta-potential, peptide loading, yield, and morphology. The inclusion of ionic additives in the nanoparticle formulation significantly influenced dalargin entrapment efficiency (EE). For example, with the PLGA/SDS formulation EE increased from 13.3% to 91.2% and from 4.1% to 68.6% with the solvent diffusion and evaporation methods, respectively. The inclusion of ionic surfactant SDS has also lead to the formation of smaller size of nanoparticles. Isothermal titration microcalorimetry revealed a strong interaction between dalargin and DS, medium level interaction with SDS, and weak interaction with SB-CD. The results of this study suggest that a strong ionic interaction between peptides and additives may lead to enhanced peptide incorporation but also increased particle size. Intermediate ionic interaction, especially when it is associated with the formation of reversed micelles in a hydrophobic polymer solution, could be used to enhance the incorporation of hydrophilic peptides in PLGA and mPEG-PLGA nanoparticles.

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Dermatan carriers for neovascular transport targeting, deep tumor penetration and improved therapy

Cited by 30 publications

References 36 publications

Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer

Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer

Quantitative mitochondrial redox imaging of breast cancer metastatic potential

Effect of formulation factors on incorporation of the hydrophilic peptide dalargin into PLGA and mPEG‐PLGA nanoparticles

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