Dermal regenerative matrix use in burn patients: A systematic review

Hicks, Katie; Huynh, Minh; Jeschke, Marc G.; Malic, Claudia

doi:10.1016/j.bjps.2019.07.021

Cited by 36 publications

(32 citation statements)

References 69 publications

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“…While the primary goal of the rapid and permanent coverage of burn wounds is to protect from infections, these regenerative cell-based therapies have occasionally been a ground for the initiation of infections in the clinic. In fact, infection of the DRTs and the graft site is a major early complication associated with this type of treatment [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns

et al. 2021

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Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and subsequent lysis of the collagen leading to a cell therapy loss. In this article, we report the development of a new generation of cell therapy formulations with the capacity to resist infections through the bactericidal effect of antimicrobial peptide dendrimers and the anti-virulence effect of anti-quorum sensing MvfR (PqsR) system compounds, which are incorporated into their formulation. Anti-quorum sensing compounds limit the pathogenicity and antibiotic tolerance of pathogenic bacteria involved in the burn wound infections, by inhibiting their virulence pathways. For the first time, we report a biological cell therapy dressing incorporating live progenitor cells, antimicrobial peptide dendrimers, and anti-MvfR compounds, which exhibit bactericidal and anti-virulence properties without compromising the viability of the progenitor cells.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns

et al. 2021

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“…The dermal matrix allows for migration of fibroblasts and macrophages and becomes vascularized and incorporated into the body, and the silastic epidermis is removed and autografted 3 weeks after application. Integra carries the advantage of easy storage and decreased contracture compared to autograft only [104,105], and of being able to survive on small exposed areas of bone or tendon, on which autograft alone does not survive. Disadvantages include infections and its high cost [17,105].…”

Section: Skin Substitutesmentioning

confidence: 99%

“…Integra carries the advantage of easy storage and decreased contracture compared to autograft only [104,105], and of being able to survive on small exposed areas of bone or tendon, on which autograft alone does not survive. Disadvantages include infections and its high cost [17,105]. Biodegradable Temporizing Matrix, or BTM ® , is a synthetic polyurethane dermal substitute developed in 2012 by Greenwood that incorporates into the body through ingrowth of blood vessels and fibroblast infiltration [106,107].…”

Section: Skin Substitutesmentioning

confidence: 99%

Contemporary Aspects of Burn Care

Khatib

Jeschke

2021

Medicina

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The past one hundred years have seen tremendous improvements in burn care, allowing for decreased morbidity and mortality of this pathology. The more prominent advancements occurred in the period spanning 1930–1980; notably burn resuscitation, early tangential excision, and use of topical antibiotic dressings; and are well documented in burn literature. This article explores the advancements of the past 40 years and the areas of burn management that are presently topics of active discussion and research.

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“…However, stable healing cannot be achieved in all patients using these techniques. Although some progress has been made using different templates and matrices [ 10 ], these techniques are still dependent on a minimum degree of perfusion of the wound bed, which is not the situation following high voltage electrical trauma, and are limited in the thickness and quality of the soft tissue they provide [ 11 ].…”

Section: Indicationmentioning

confidence: 99%

Implementation and Validation of Free Flaps in Acute and Reconstructive Burn Care

et al. 2021

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Microsurgical free flap reconstruction in acute burn care offers the option of reconstructing even challenging defects in a single stage procedure. Due to altered rheological and hemodynamic conditions in severely burned patients, it bears the risk of a higher complication rate compared to microsurgical reconstruction in other patients. To avoid failure, appropriate indications for free flap reconstruction should be reviewed thoroughly. Several aspects concerning timing of the procedure, individual flap choice, selection and preparation of the recipient vessels, and perioperative measures must be considered. Respecting these specific conditions, a low complication rate, comparable to those seen in microsurgical reconstruction of other traumatic limb defects, can be observed. Hence, the free flap procedure in acute burn care is a relatively safe and reliable tool in the armamentarium of acute burn surgery. In reconstructive burn care, microsurgical tissue transfer is routinely used to treat scar contractures. Due to the more robust perioperative condition of patients, even lower rates of complication are seen in microsurgical reconstruction.

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Dermal regenerative matrix use in burn patients: A systematic review

Cited by 36 publications

References 69 publications

Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns

Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns

Contemporary Aspects of Burn Care

Implementation and Validation of Free Flaps in Acute and Reconstructive Burn Care

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