Dermal Penetration and Distribution of 14C-Labeled Permethrin Isomers

Snodgrass, Hubert L.; Nelson, Douglas C.

doi:10.21236/ada130605

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only 45-54% of the excreted radiocarbon from c/spermethrin appeared in rat urine following oral ingestion, compared to 81-90% of that from frans-permethrin (Gaughan et al, 1977). Similarily, the recoveries in dog urine were 25% (cis) and 50% (trans) after iv infusion (Snodgrass and Nelson, 1982). These results may be attributable to the metabolic lability of the ester group of the trans isomer (Shono et al, 1979); however, they may also indicate greater excretion of cis residues via the fecal route and/or greater retention in body tissues (e.g., fat).…”

Section: Discussionmentioning

confidence: 75%

Percutaneous absorption ofcis‐andtrans‐permethrin in rhesus monkeys and rats: Anatomic site and interspecies variation

Sidon

Moody²,

Franklin

1988

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Dermal absorption of cis- and trans-permethrin isomers was determined in rhesus monkeys and Sprague-Dawley rats. Four 14C radiolabels were used (cis alcohol, cis cyclopropyl, trans alcohol, and trans cyclopropyl). One microcurie of each radiolabel was applied to either the forehead or forearm of rhesus monkeys or to the midlumbosacral region of the rat. Urine was collected for 7 or 14 d. Correction factors for incomplete urine excretion were derived from measurements of radiolabel in the urine following im injection of an equivalent dose. It was noted that the total im dose recovered in the urine of both species was lower for the cis isomer than for the trans isomer. There was no significant difference between the dermal absorption of the cis isomer and that of the trans isomer in monkeys. The forehead, however, was more permeable for both isomers than the forearm (alcohol- and cyclopropyl-labeled cis and trans isomers, respectively, showed permeation in forehead, cis 28 +/- 6%, 24 +/- 6%, trans 21 +/- 3%, 14 +/- 4%, forearm, cis 9 +/- 3%, 9 +/- 3%, trans 12 +/- 3%, and 5 +/- 2%). There was no difference between absorption of the isomers (cis 46 +/- 4%, trans 43 +/- 5%) in rats, but absorption was significantly greater than in monkeys. The IM urinary t1/2 values in monkeys and rats were similar for both isomers (0.8-1.1 d).

show abstract

Section: Discussionmentioning

confidence: 75%

Percutaneous absorption ofcis‐andtrans‐permethrin in rhesus monkeys and rats: Anatomic site and interspecies variation

Sidon

Moody²,

Franklin

1988

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

show abstract

“…But are hedgehogs otherwise exposed to insecticides intended for the treatment of ectoparasites in pets? As these substances are excreted from dogs and cats through urine and faeces [133][134][135], there is a risk that hedgehogs may come into close contact with the compounds, as they sometimes cover themselves in faeces from dogs and cats, likely as an attempt to disguise their own smell for predators. Furthermore, sharing sources of fresh water with pets could also lead to an exposure of insecticides used for treatment against endoparasites, if a dog swims or rolls in a small puddle or a lake or stream from which the hedgehog drinks, as a range of the products against ectoparasites are nowadays "spot on" products, which are applied directly onto the skin and fur of the pets [136].…”

Section: More Research On Exposure To Xenobioticsmentioning

confidence: 99%

A Review of the Occurrence of Metals and Xenobiotics in European Hedgehogs (Erinaceus europaeus)

Rasmussen,

Pertoldi,

Roslev

et al. 2024

Animals

View full text Add to dashboard Cite

Monitoring data from several European countries indicate that European hedgehog (Erinaceus europaeus) populations are declining, and research exploring the causes of the decline, including exposure to potentially harmful xenobiotics and metals, may inform conservation initiatives to protect this species in the wild. Hedgehogs are ground-dwelling mammals, feeding on a range of insects, slugs, snails, and earthworms, as well as eggs, live vertebrates, and carrion, including carcasses of apex predator species representing higher levels of the food chain. Consequently, hedgehogs come into close contact with contaminants present in their habitats and prey. This review investigated the studies available on the subject of the occurrence of metals and organic xenobiotics in hedgehogs. This study found that a vast range of different pesticides; persistent organic pollutants (POPs), including organochlorine compounds and brominated flame retardants (BFRs); as well as toxic heavy metals could be detected. Some compounds occurred in lethal concentrations, and some were associated with a potential adverse effect on hedgehog health and survival. Due to their ecology, combined with the opportunity to apply non-invasive sampling techniques using spines as sampling material, we suggest that the European hedgehog is a relevant bioindicator species for monitoring the exposure of terrestrial wildlife to potential toxicants in urban and rural environments.

show abstract

4-Nitrophenol

Chemie¹

1993

Toxicological Evaluations 6

View full text Add to dashboard Cite

Dermal Penetration and Distribution of 14C-Labeled Permethrin Isomers

Cited by 4 publications

References 2 publications

Percutaneous absorption ofcis‐andtrans‐permethrin in rhesus monkeys and rats: Anatomic site and interspecies variation

Percutaneous absorption ofcis‐andtrans‐permethrin in rhesus monkeys and rats: Anatomic site and interspecies variation

A Review of the Occurrence of Metals and Xenobiotics in European Hedgehogs (Erinaceus europaeus)

4-Nitrophenol

Contact Info

Product

Resources

About