Dermal immune responses against Psoroptes ovis in two cattle breeds and effects of anti-inflammatory dexamethasone treatment on the development of psoroptic mange

Chen, Zhenzhen; Claerebout, Edwin; Chiers, Koen; Pas, Mathilde L; Pardon, Bart; Mol, Wouter van; Casaert, Stijn; Wilde, Nathalie De; Duchateau, Luc; Geldhof, Peter

doi:10.1186/s13567-020-00874-x

Cited by 16 publications

(3 citation statements)

References 32 publications

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“…Pathogens such as Mycoplasma hyopneumoniae, Glaesserella parasuis , and Streptococcus suis are associated with pericarditis [ 37 ]. Of these pathogens, S. suis is the only one that has ear biting as an associated risk factor [ 38 ]. Furthermore, a recent study showed that pig saliva is the major natural habitat of S. suis, suggesting that saliva is the most probable source of infection by S. suis [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Adding value to food chain information: using data on pig welfare and antimicrobial use on-farm to predict meat inspection outcomes

et al. 2021

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Background Using Food Chain Information data to objectively identify high-risk animals entering abattoirs can represent an important step forward towards improving on-farm animal welfare. We aimed to develop and evaluate the performance of classification models, using Gradient Boosting Machine algorithms that utilise accurate longitudinal on-farm data on pig health and welfare to predict condemnations, pluck lesions and low cold carcass weight at slaughter. Results The accuracy of the models was assessed using the area under the receiver operating characteristics (ROC) curve (AUC). The AUC for the prediction models for pneumonia, dorsocaudal pleurisy, cranial pleurisy, pericarditis, partial and total condemnations, and low cold carcass weight varied from 0.54 for pneumonia and 0.67 for low cold carcass weight. For dorsocaudal pleurisy, ear lesions assessed on pigs aged 12 weeks and antimicrobial treatments (AMT) were the most important prediction variables. Similarly, the most important variable for the prediction of cranial pleurisy was the number of AMT. In the case of pericarditis, ear lesions assessed both at week 12 and 14 were the most important variables and accounted for 33% of the Bernoulli loss reduction. For predicting partial and total condemnations, the presence of hernias on week 18 and lameness on week 12 accounted for 27% and 14% of the Bernoulli loss reduction, respectively. Finally, AMT (37%) and ear lesions assessed on week 12 (15%) were the most important variables for predicting pigs with low cold carcass weight. Conclusions The findings from our study show that on farm assessments of animal-based welfare outcomes and information on antimicrobial treatments have a modest predictive power in relation to the different meat inspection outcomes assessed. New research following the same group of pigs longitudinally from a larger number of farms supplying different slaughterhouses is required to confirm that on farm assessments can add value to Food Chain Information reports.

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Section: Discussionmentioning

confidence: 99%

Adding value to food chain information: using data on pig welfare and antimicrobial use on-farm to predict meat inspection outcomes

et al. 2021

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“…were found, although in these cases, histological signs of inflammation were not found, and therefore the role of these agents in the etiology of abortions is unclear. Nevertheless, C. pecorum has incidentally been described as a possible cause of small ruminant abortion [ 12 , 13 ]. Other major causes of abortions were Campylobacter spp., Listeria spp., Toxoplasma gondii , Escherichia coli , and Yersinia enterocolitica.…”

Section: Discussionmentioning

confidence: 99%

An Accessible Diagnostic Toolbox to Detect Bacterial Causes of Ovine and Caprine Abortion

et al. 2021

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Results of laboratory investigations of ovine and caprine cases of abortion in the lambing season 2015–2016 were analyzed, using pathology records of submissions to Royal GD (Deventer, the Netherlands) from January until and including April 2016, in comparison with the results of two accessible alternative techniques for sampling aborted lambs and kids, swabbing the fetal oropharynx and puncture of the fetal lung. Chlamydia abortus was the main cause of abortion in sheep as well as in goats. Other causes of abortion were Campylobacter spp., Listeria spp., Escherichia coli, and Yersinia enterocolitica. Ovine pathological submissions resulted more often in detecting an infectious agent compared to caprine submissions. For the three main bacterial causes of abortion, Campylobacter spp., Listeria spp., and Chlamydia spp., compared to results of the pathological examination, oropharynx mucus, and fetal lung puncture samples showed an observed agreement of 0.87 and 0.89, an expected agreement of 0.579 and 0.584, and a kappa value of 0.691 and 0.737 (95% CI: 0.561–0.82 and 0.614–0.859), respectively. The agreement between the results of the pathological examination and both fetal lung puncture and oropharynx mucus samples was classified as good. In conclusion, although a full step-wise post-mortem examination remains the most proper way of investigating small ruminant abortions, the easily accessible, low-threshold tools for practitioners and farmers as described in this paper not only provide reliable results compared to results of the post-mortem examination but also stimulates farmers and veterinarians to submit fetuses and placentas if necessary. Suggestions for further improvement of both alternatives have been summarized. Both alternatives could also be tailor-made for specific regions with their specific causes of abortion.

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“…These similar findings have been observed in cattles and rabbits with P. ovis infestations. In the susceptible breed of Belgian blue cattle, eosinophil numbers in skin lesions were more pronounced in comparison with the non-susceptible breed of Holstein–Friesian cattle [ 6 ]. In rabbits with P. ovis infestations, eosinophil levels showed a significant elevation in severely infected cases [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Macrophage Migration Inhibitory Factor in Psoroptes ovis: Molecular Characterization and Potential Role in Eosinophil Accumulation of Skin in Rabbit and Its Implication in the Host–Parasite Interaction

et al. 2023

IJMS

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Psoroptes ovis, a common surface-living mite of domestic and wild animals worldwide, results in huge economic losses and serious welfare issues in the animal industry. P. ovis infestation rapidly causes massive eosinophil infiltration in skin lesions, and increasing research revealed that eosinophils might play an important role in the pathogenesis of P. ovis infestation. Intradermal injection of P. ovis antigen invoked massive eosinophil infiltration, suggesting that this mite should contain some relative molecules involved in eosinophil accumulation in the skin. However, these active molecules have not yet been identified. Herein, we identified macrophage migration inhibitor factor (MIF) in P. ovis (PsoMIF) using bioinformatics and molecular biology methods. Sequence analyses revealed that PsoMIF appeared with high similarity to the topology of monomer and trimer formation with host MIF (RMSD = 0.28 angstroms and 2.826 angstroms, respectively) but with differences in tautomerase and thiol-protein oxidoreductase active sites. Reverse transcription PCR analysis (qRT-PCR) results showed that PsoMIF was expressed throughout all the developmental stages of P. ovis, particularly with the highest expression in female mites. Immunolocalization revealed that MIF protein located in the ovary and oviduct of female mites and also localized throughout the stratum spinosum, stratum granulosum, and even basal layers of the epidermis in skin lesions caused by P. ovis. rPsoMIF significantly upregulated eosinophil-related gene expression both in vitro (PBMC: CCL5, CCL11; HaCaT: IL-3, IL-4, IL-5, CCL5, CCL11) and in vivo (rabbit: IL-5, CCL5, CCL11, P-selectin, ICAM-1). Moreover, rPsoMIF could induce cutaneous eosinophil accumulation in a rabbit model and increased the vascular permeability in a mouse model. Our findings indicated that PsoMIF served as one of the key molecules contributing to skin eosinophil accumulation in P. ovis infection of rabbits.

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Dermal immune responses against Psoroptes ovis in two cattle breeds and effects of anti-inflammatory dexamethasone treatment on the development of psoroptic mange

Cited by 16 publications

References 32 publications

Adding value to food chain information: using data on pig welfare and antimicrobial use on-farm to predict meat inspection outcomes

Adding value to food chain information: using data on pig welfare and antimicrobial use on-farm to predict meat inspection outcomes

An Accessible Diagnostic Toolbox to Detect Bacterial Causes of Ovine and Caprine Abortion

Macrophage Migration Inhibitory Factor in Psoroptes ovis: Molecular Characterization and Potential Role in Eosinophil Accumulation of Skin in Rabbit and Its Implication in the Host–Parasite Interaction

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