Dermal exposure to tannery effluent causes neurobehavioral changes in C57Bl/6J and Swiss mice

Silva, Wellington Alves Mizael da; Mendes, Bruna de Oliveira; Guimarães, Abraão Tiago Batista; Rabelo, Letícia Martins; Ferreira, Raíssa de Oliveira; Silva, Bianca Costa e; Souza, Joyce Moreira de; Menezes, Ivandilson Pessoa Pinto de; Rodrigues, Aline Sueli de Lima; Malafaia, Guilherme

doi:10.1016/j.chemosphere.2016.06.083

Cited by 19 publications

(7 citation statements)

References 40 publications

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“…However, there are few studies on dermal exposure to tannery effluent on mice. Recently, the present research group dermally exposed male C57Bl6J and Swiss mice to tannery effluent and found anxiogenic behavior in C57Bl/6J animals (Silva et al, 2016), differently from what was observed in the current study. On that occasion, Swiss males dermally exposed to tannery effluent for 15 days did not present changes related to anxiety disorders, even when the high neurotoxic potential of the evaluated pollutant was taken into account.…”

Section: Resultscontrasting

confidence: 97%

“…Studies have found different effects of oral exposure to tannery effluent on mammals, and their results converge to the neurotoxic potential of the assessed pollutants when it comes to predictive anxiety (Siqueira et al, 2011;Silva et al, 2016;Guimarães et al, 2016a) and anxiolytic behaviors (Almeida et al, 2016), to depression predictors (Souza et al, 2017), memory deficit (Rabelo et al, 2016), as well as to the neurobehavioral effects detrimental to the offspring of parents exposed to these xenobiotics (Guimarães et al, 2016b). The possible action of organic and inorganic effluent components on the normal functioning of the central nervous system can explain the diversity of herein observed behavioral effects.…”

Section: Resultsmentioning

confidence: 93%

“…On the other hand, it is impossible to deny that the intrinsic biological characteristics of C57Bl/6J mice may have boosted the neurotoxicity effects found in animals studied by Silva et al (2016). Therefore, these animals may suffer from a lower or higher degree of environmental influence, and it makes these experimental models lesser or more susceptible to some xenobiotics (Casellas et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

“…However, these studies are incipient when it comes to the effects of dermal tannery effluent on laboratory animals. The study by Silva et al (2016) stands out among these studies; it simulated the labor 3 Short-term dermal exposure to tannery effluent … Rev. Ambient.…”

Section: Introductionmentioning

confidence: 99%

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2018

Rev. ambiente água

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The state of Bahia's main climatic characteristic is the high spatial and chronological variability of precipitation. This heterogeneity may be used to determine of pluviometrically homogeneous areas that can define mesoregions in the state, since they allow better management of water resources and help in the elaboration of agricultural studies. The mesoregions already proposed by the scientific community for the state were based only on the annual precipitation in the proximity of the pluviometric stations. In this paper, besides these parameters, spatial and chronological rainfall distribution was considered, i.e., the Precipitation Concentration Degree (PCD) and Precipitation Concentration Period (PCP). The new zoning is based on an update of a study defined in 2000 that divided Bahia into eight mesoregions. Thus, 180 pluviometric stations were distributed throughout the state and grouped conforming to the division previously described. It was concluded that some stations of the same mesoregion had presented conflicting values for the analyzed parameters and, therefore, should not belong to the same area. Starting from an arrangement of the collection stations, considering their proximity, annual precipitation and statistical parameters, a new zoning for Bahia with 10 clusters was defined and validated through the statistical treatment of data.

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Section: Resultscontrasting

confidence: 97%

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2018

Rev. ambiente água

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Section: Introductionmentioning

confidence: 99%

Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice

et al. 2018

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Tannery is a highly polluting activity due to the waste generated by bovine skin processing. Although there are several studies highlighting the health issues faced by workers exposed to tannery effluent, there are no records of experiments testing the neurobehavioral effects resulting from direct contact with this pollutant. Thus, the aim of the current study is to assess the possible neurobehavioral effects of dermal exposure to tannery effluent on male Swiss mice. Animals were divided in three groups, which were subjected to the same experimental time period and conditions: effluent group - animals in direct contact with tannery effluent (for 20 days); control group - animals in contact with pure water; and dry-control group - animals not exposed to water or to tannery effluent. Neurobehavioral tests started on the 17th experimental day. Results of the elevated plus-maze test (anxiety prediction) showed no anxiogenic or anxiolytic effects, memory deficit or depressive symptoms on animals exposed to tannery effluent. Thus, the current results do not support the hypothesis that male Swiss mice dermal exposure to tannery effluents for the same time period and experimental conditions leads to neurobehavioral changes. Therefore, the herein adopted exposure protocol was not good to study the effects of dermal exposure to tannery effluent on the chosen experimental model.

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Histological liver chances in Swiss mice caused by tannery effluent

Rabelo

Guimarães

Souza

et al. 2017

Environ Sci Pollut Res

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Although tannery effluents are known for being highly toxic to organisms, reports about the effects of the intake of these xenobiotics on experimental mammal models are recent. Studies about the damages the chronic intake of these effluents can cause in the liver of outbred mice remain an unexplored field. Thus, the aim of the present study is to assess (histological) the hepatic condition of Swiss mice (outbred strain) chronically exposed to the intake of different raw tannery effluent concentrations diluted in water for 150 days. Accordingly, the mice (males and females) were divided in the following groups: control group-animals treated with drinking water, only; and groups 5 and 10%-treated with raw tannery effluent diluted in water. After exposure, the animals were subjected to euthanasia for liver fragment sample collection and histological analysis, respectively. Moderate hydropic degeneration was observed in the centrilobular regions of the liver of mice exposed to 5 and 10% tannery effluent, as well as greater amounts of hepatocytes presenting karyomegaly and necrotic hepatocytes, and a smaller amount of Kuffer cells in the liver of mice exposed to the xenobiotic. Finally, animals exposed to 10% tannery effluent showed mild hyperplasia of the bile ducts in the portal areas and fibroblast proliferation around the bile ducts, thus suggesting a fibrous process. Except for the frequency of hepatocytes presenting karyomegaly (lower in females), the herein observed hepatic changes were similar in male and female Swiss mice. Accordingly, the present data support the hypothesis that the chronic intake of tannery effluent by outbred mice (Swiss) causes damages in the liver, a fact that broadens the knowledge about the toxic potential of this pollutant, which goes beyond that of C57Bl/6J male mice (inbred strain).

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Dermal exposure to tannery effluent causes neurobehavioral changes in C57Bl/6J and Swiss mice

Cited by 19 publications

References 40 publications

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Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice

Histological liver chances in Swiss mice caused by tannery effluent

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