Dermal exposure to cobalt studied<i>in vitro</i>in keratinocytes – effects of cobalt exposure on inflammasome activated cytokines, and mRNA response

Klasson, Maria; Lindberg, Magnus; Westberg, Håkan; Bryngelsson, Ing‐Liss; Tuerxun, Kedeye; Persson, Annina H.; Särndahl, Eva

doi:10.1080/1354750x.2021.1975823

Cited by 5 publications

(4 citation statements)

References 50 publications

(52 reference statements)

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“…In addition to the presence in immunocompetent innate immune cells, an increasing number of studies demonstrate localization and involvement of the NLRP3 inflammasome in cells at important exposure sites, including alveolar, intestinal, and skin epithelia ( 70 – 72 ).…”

Section: Nlrp3 Inflammasomementioning

confidence: 99%

NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

et al. 2023

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Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly investigated particulates, MNPs may penetrate epithelial barriers, potentially triggering a cascade of signaling events leading to cell damage and inflammation. Inflammasomes are intracellular multiprotein complexes and stimulus-induced sensors critical for mounting inflammatory responses upon recognition of pathogen- or damage-associated molecular patterns. Among these, the NLRP3 inflammasome is the most studied in terms of activation via particulates. However, studies delineating the ability of MNPs to affect NLRP3 inflammasome activation are still rare. In this review, we address the issue of MNPs source and fate, highlight the main concepts of inflammasome activation via particulates, and explore recent advances in using inflammasome activation for assessment of MNP immunotoxicity. We also discuss the impact of co-exposure and MNP complex chemistry in potential inflammasome activation. Development of robust biological sensors is crucial in order to maximize global efforts to effectively address and mitigate risks that MNPs pose for human health.

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Section: Nlrp3 Inflammasomementioning

confidence: 99%

NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

et al. 2023

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“…Exposure to high levels of CoCl 2 significantly increased the NLRP3 expression, caspase-1 activity, and IL-1b secretion (64). Although a high CoCl 2 level can induce apoptosis in T lymphocytes, CoCl 2 -treated monocytes did not undergo apoptosis as the effect of p53 was counteracted by the anti-apoptotic activity of the activation of NF-kB and the inflammasome danger signaling pathway leading to the production of pro-inflammatory cytokines (111).…”

Section: Cobaltmentioning

confidence: 96%

NLRP3 inflammasome activation in response to metals

Huang

Zhang²,

Qiu³

et al. 2023

Front. Immunol.

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Implant surgery is followed by a series of inflammatory reactions that directly affect its postoperative results. The inflammasome plays a vital role in the inflammatory response by inducing pyroptosis and producing interleukin-1β, which plays a critical role in inflammation and tissue damage. Therefore, it is essential to study the activation of the inflammasome in the bone healing process after implant surgery. As metals are the primary implant materials, metal-induced local inflammatory reactions have received significant attention, and there has been more and more research on the activation of the NLRP3 (NOD-like receptor protein-3) inflammasome caused by these metals. In this review, we consolidate the basic knowledge on the NLRP3 inflammasome structures, the present knowledge on the mechanisms of NLRP3 inflammasome activation, and the studies of metal-induced NLRP3 inflammasome activation.

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“…This is also viable with low circulating ion levels [ 196 ]. Cobalt and chromium alloy particles as well as their ions activate the NLR family pyrin domain containing 3 (NLPR3) inflammasome and caspase-1 mediated pathway, leading to activation of pro-interleukin IL-1B and pro-IL-18 as a part of an innate immunologic response [ 197 , 198 , 199 ]. This in turn activates NFκB that stimulates various pro-inflammatory responses [ 156 ].…”

Section: Biological Response To Metal Implants Used In Lifmentioning

confidence: 99%

Metallic Implants Used in Lumbar Interbody Fusion

et al. 2022

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Over the last decade, pedicle fixation systems have evolved and modifications in spinal fusion techniques have been developed to increase fusion rates and improve clinical outcomes after lumbar interbody fusion (LIF). Regarding materials used for screw and rod manufacturing, metals, especially titanium alloys, are the most popular resources. In the case of pedicle screws, that biomaterial can be also doped with hydroxyapatite, CaP, ECM, or tantalum. Other materials used for rod fabrication include cobalt–chromium alloys and nitinol (nickel–titanium alloy). In terms of mechanical properties, the ideal implant used in LIF should have high tensile and fatigue strength, Young’s modulus similar to that of the bone, and should be 100% resistant to corrosion to avoid mechanical failures. On the other hand, a comprehensive understanding of cellular and molecular pathways is essential to identify preferable characteristics of implanted biomaterial to obtain fusion and avoid implant loosening. Implanted material elicits a biological response driven by immune cells at the site of insertion. These reactions are subdivided into innate (primary cellular response with no previous exposure) and adaptive (a specific type of reaction induced after earlier exposure to the antigen) and are responsible for wound healing, fusion, and also adverse reactions, i.e., hypersensitivity. The main purposes of this literature review are to summarize the physical and mechanical properties of metal alloys used for spinal instrumentation in LIF which include fatigue strength, Young’s modulus, and corrosion resistance. Moreover, we also focused on describing biological response after their implantation into the human body. Our review paper is mainly focused on titanium, cobalt–chromium, nickel–titanium (nitinol), and stainless steel alloys.

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Dermal exposure to cobalt studiedin vitroin keratinocytes – effects of cobalt exposure on inflammasome activated cytokines, and mRNA response

Abstract: Särndahl (2021): Dermal exposure to cobalt studied in vitro in keratinocytes -effects of cobalt exposure on inflammasome activated cytokines, and mRNA response, Biomarkers,

Cited by 5 publications

References 50 publications

NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

NLRP3 inflammasome activation in response to metals

Metallic Implants Used in Lumbar Interbody Fusion

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