Dermal Absorption of Diquat and Potential
Occupational Risk

Yastrub, Tatyana O; Omelchuk, S. Т.; Yastrub, Andrii M

doi:10.36740/wlek202007127

Cited by 6 publications

(2 citation statements)

References 8 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PQ residues in food are usually not easily detectable and some foods have been reported to have levels of up to 0.2 mg/kg, whereas the acceptable daily intake is 0.004 mg/kg [ 7 ]. In addition, different papers evidence human illnesses associated with PQ/DQ acute exposure and poisoning [ 8 , 9 , 10 , 11 ]. Other studies enlighten the effect of an exposure associated with multiple pesticide application events resulting in multiple short-term or pulse exposures.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Analysis of the Binding of Paraquat and Diquat Herbicides to Biosubstrates

Macii

Detti

Bloise

et al. 2021

IJERPH

View full text Add to dashboard Cite

The study of the interaction of persistent organic pollutants with biosubstrates helps to unravel the pathways for toxicity, however, few mechanistic data are present in the literature for these systems. We analyzed the binding of paraquat (PQ) and diquat (DQ) herbicides to natural calf thymus DNA and a DNA G-quadruplex by spectrophotometric titrations, ethidium bromide exchange tests, viscometry, and melting experiments. The interaction with bovine serum albumin (BSA) protein was studied spectrofluorimetrically at different temperatures. The retention of the targets on positive, negative, and neutral micellar aggregates and liposomes was analyzed by ultrafiltration experiments. Despite some favorable features, PQ and DQ only externally bind natural DNA and do not interact with DNA oligonucleotides. Both herbicides bind bovine serum albumin (BSA). PQ binds BSA mainly according to an electrostatics-driven process. However, ultrafiltration data also show that some hydrophobic contribution participates in the features of these systems. The practical problems related to unfavorable spectroscopic signals and inner filter effects are also discussed. Overall, both herbicides show a low affinity for nucleic acids and weak penetration into liposomes; in addition, the equilibrium constants values found for BSA system suggest optimal conditions for transport in the body.

show abstract

Section: Introductionmentioning

confidence: 99%

Spectroscopic Analysis of the Binding of Paraquat and Diquat Herbicides to Biosubstrates

Macii

Detti

Bloise

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Diquat (1,10-ethylene-2,20-bipyridinium, DQ) is a widely used non-selective herbicide that belongs to bipyridine ( Figure 1 ) ( 1 , 2 ). The toxicity of DQ is less different than that of other herbicides like paraquat (PQ) due to its rapid degradation in the environment.…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute Diquat Poisoning on Liver Mitochondrial Apoptosis and Autophagy in Ducks

Chen

Lin

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

Diquat (DQ) is an effective herbicide and is widely used in agriculture. Due to persistent and frequent applications, it can enter into aquatic ecosystem and induce toxic effects to exposed aquatic animals. The residues of DQ via food chain accumulate in different tissues of exposed animals including humans and cause adverse toxic effects. Therefore, it is crucial and important to understand the mechanisms of toxic effects of DQ in exposed animals. We used ducks as test specimens to know the effects of acute DQ poisoning on mechanisms of apoptosis and autophagy in liver tissues. Results on comparison of various indexes of visceral organs including histopathological changes, apoptosis, autophagy-related genes, and protein expression indicated the adverse effects of DQ on the liver. The results of our experimental trial showed that DQ induces non-significant toxic effects on pro-apoptotic factors like BAX, BAK1, TNF-α, caspase series, and p53. The results revealed that anti-apoptotic gene Parkin was significantly upregulated, while an upward trend was also observed for Bcl2, suggesting that involvement of the anti-apoptotic factors in ducklings plays an important role in DQ poisoning. Results showed that DQ significantly increased the protein expression level of the autophagy factor Beclin 1 in the liver. Results on key autophagy factors like LC3A, LC3B, and p62 showed an upward trend at gene level, while the protein expression level of both LC3B and p62 reduced that might be associated with process of translation affected by the pro-apoptotic components such as apoptotic protease that inhibits the occurrence of autophagy while initiating cell apoptosis. The above results indicate that DQ can induce cell autophagy and apoptosis and the exposed organism may resist the toxic effects of DQ by increasing anti-apoptotic factors.

show abstract

In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach

Acar

2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

Dermal Absorption of Diquat and Potential Occupational Risk

Cited by 6 publications

References 8 publications

Spectroscopic Analysis of the Binding of Paraquat and Diquat Herbicides to Biosubstrates

Spectroscopic Analysis of the Binding of Paraquat and Diquat Herbicides to Biosubstrates

Effects of Acute Diquat Poisoning on Liver Mitochondrial Apoptosis and Autophagy in Ducks

In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach

Contact Info

Product

Resources

About