Dermal absorption for pesticide health risk assessment: Harmonization of study design and data reporting for North American Regulatory submissions

Sullivan, Kristie; Aggarwal, Manoj; Akins, J; Fabian, Eric; Heylings, Jon R.; Raabe, Hans; Shah, Prakashchandra P V; Wiemann, Christiane; Peffer, Richard C.

doi:10.1016/j.yrtph.2017.09.012

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…Further, it was found that the concentration of lead and chromium were higher than the corresponding screening levels in soils. (Sullivan et al, 2017). This report highlights the concerns of regulators as well as the regulated community.…”

Section: Human Healthmentioning

confidence: 87%

Ecological and Human Health Risk Assessment

Charabi

Choudri

Ahmed

2018

Water Environment Research

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The review of literature in this paper includes the assessment of risk process and addresses issues of both human as well as ecological receptors. The main objective of this review is to highlight an overview of the scientific research literature published in year 2017. The review is focused on assessment of risk on human and ecology published in the literature such as analysis, methodology, interpretation, management, uncertainty, policy and regulatory guidance. The review on ecological and human health risk assessment is divided into two main sections namely ecological and human health. The focus of the review is on the risk assessment process as it is applied to human health, ecoological systems, site investigation, aspects of remediation as well as natural resources.

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Section: Human Healthmentioning

confidence: 87%

Ecological and Human Health Risk Assessment

Charabi

Choudri

Ahmed

2018

Water Environment Research

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“…Guidelines are available from OECD for dermal absorption studies, namely the Guidance Document 28 for the conduct of skin absorption studies (OECD, 2004), the Test Guideline 428 for in vitro assays and, later, the Guidance Notes 156 document on dermal absorption that is currently under review (OECD, 2019). Meanwhile, varied authors have provided practical insights for revision of the skin absorption guidance documents and defended further harmonization to improve the quality of in vitro permeation studies (Hopf et al, 2020;Sullivan et al, 2017).…”

Section: Methods Harmonizationmentioning

confidence: 99%

Reassessment of the experimental skin permeability coefficients of polycyclic aromatic hydrocarbons and organophosphorus pesticides

Silva

Marques‐da‐Silva

Lagoa

2021

Environmental Toxicology and Pharmacology

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“…One should be aware that the percutaneous absorption results of a given substance (K p , J ss ) are influenced by many factors such as donor composition, acceptor composition and other experimental conditions 12 , 15 , 16 , 59 .…”

Section: Usage Notesmentioning

confidence: 99%

“… Skin donor type The guidelines proposed to carry out the studies either with human skin from autopsies (cadaver skin) or with surgical discard skin, the two main sources of supply 10 . Surgical discard skin is generally preferred but cadaver skin, which can be more convenient, is also accepted for percutaneous absorption studies as long as the integrity of the barrier is verified 16 , as the decrease of barrier integrity could lead to increased permeability. Nevertheless, as the skin is not considered viable, the metabolism of the substance cannot be studied.…”

Section: Usage Notesmentioning

confidence: 99%

An update of skin permeability data based on a systematic review of recent research

Chedik,

Baybekov,

Cosnier

et al. 2024

Sci Data

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The cutaneous absorption parameters of xenobiotics are crucial for the development of drugs and cosmetics, as well as for assessing environmental and occupational chemical risks. Despite the great variability in the design of experimental conditions due to uncertain international guidelines, datasets like HuskinDB have been created to report skin absorption endpoints. This review updates available skin permeability data by rigorously compiling research published between 2012 and 2021. Inclusion and exclusion criteria have been selected to build the most harmonized and reusable dataset possible. The Generative Topographic Mapping method was applied to the present dataset and compared to HuskinDB to monitor the progress in skin permeability research and locate chemotypes of particular concern. The open-source dataset (SkinPiX) includes steady-state flux, maximum flux, lag time and permeability coefficient results for the substances tested, as well as relevant information on experimental parameters that can impact the data. It can be used to extract subsets of data for comparisons and to build predictive models.

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Dermal absorption for pesticide health risk assessment: Harmonization of study design and data reporting for North American Regulatory submissions

Cited by 10 publications

References 23 publications

Ecological and Human Health Risk Assessment

Ecological and Human Health Risk Assessment

Reassessment of the experimental skin permeability coefficients of polycyclic aromatic hydrocarbons and organophosphorus pesticides

An update of skin permeability data based on a systematic review of recent research

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