Deriving utility scores for co-morbid conditions: a test of the multiplicative model for combining individual condition scores

Abstract

The findings support the simple multiplicative model for computing utilities for co-morbid conditions from the utilities for the individual conditions involved. Future work using a wider variety of conditions and data sources could serve to further evaluate and refine the approach.

Utility values in National Institute for Health and Clinical Excellence (NICE) Technology Appraisals

“…No reference is made to the adjustment of values in this way in either the 2004 or 2008 Methods Guides [1,2]. In the research in the area to date, there have been conflicting opinions regarding the most appropriate method of adjustment [7][8][9]. There is a clear need for further guidance on the appropriateness of adjusting values in this way and on the best methods for undertaking such adjustments.…”

Societal preference values for advanced melanoma health states in the United Kingdom and Australia

“…Dale et al (2002) and Fu and Kattan (2008) recommend using a minimum model, which predicts a joint-state utility as being equal to the lower of the two given single-state utilities for an individual. However, Flanagan et al (2006) recommend the use of a multiplicative model. Further research is needed in this area.…”

EuroQol (EQ-5D) health utility scores for patients with migraine

“…Their estimation can be particularly useful for health-economic evaluations of interventions that have an impact on improving patient quality of life, such as prophylactic or acute medications for migraine. A number of studies have been published describing health utility values among individuals with migraine [3][4][5][6][7][8][9][10][11][12][13]; however, all have reflected assessments essentially conducted at random time points (i.e., mixing together patients and/or periods during which migraine attacks were and were not experienced). These studies are useful for understanding the general chronic burden of migraine in the population.…”