Deriving a Continuous Point of Departure for Skin Sensitization Risk Assessment Using a Bayesian Network Model
Fleur Tourneix,
Leopold Carron,
Lionel Jouffe
et al.
Abstract:Regulations of cosmetic ingredients and products have been the most advanced in embracing new approach methodologies (NAMs). Consequently, the cosmetic industry has assumed a forerunner role in the development and implementation of animal-free next-generation risk assessment (NGRA) that incorporates defined approaches (DAs) to assess the skin sensitization potency of ingredients. A Bayesian network DA predicting four potency categories (SkinSens-BN) was constructed against reference Local Lymph Node Assay data… Show more
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