Deriving a blood-mimicking fluid for particle image velocimetry in sylgard-184 vascular models

Yousif, Majid Y.; Holdsworth, David W.; Poepping, Tamie L.

doi:10.1109/iembs.2009.5334175

Cited by 27 publications

(16 citation statements)

References 18 publications

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“…During deployment of stent-grafts and computed tomography (CT) scanning, the silicone models were completely submerged in a gelatin-water solution (Sigma Chemical Corporation, St Louis, MO, USA) with the viscosity of blood. 18,19 The solution was maintained at a constant 37 °C using a Julabo heating circulator (Julabo USA Inc., Allentown, PA, USA).…”

Section: Methodsmentioning

confidence: 99%

Gutter Characteristics and Stent Compression of Self-Expanding vs Balloon-Expandable Chimney Grafts in Juxtarenal Aneurysm Models

et al. 2020

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Purpose: To assess in silicone juxtarenal aneurysm models the gutter characteristics and compression of different types of chimney graft (CG) configurations. Materials and Methods: Fifty-seven combinations of Excluder C3 or Conformable Excluder stent-grafts (23, 26, and 28.5 mm) were deployed in 2 silicone juxtarenal aneurysm models with 3 types of CGs: Viabahn self-expanding (VSE; 6 and 13 mm) or Viabahn balloon-expandable (VBX; 6, 10, and 12 mm) stent-grafts and Advanta V12 balloon-expandable stent-grafts (ABX; 6 and 12 mm). Setups were divided into 4 groups on the basis of increasing CG and main graft (MG) diameters. Two independent observers assessed gutter size and type as well as CG compression on computed tomography scans using postprocessing software. Results: In the smaller diameter combinations (6-mm CG and 23-, 26-, and 28.5-mm MGs), both VSE (p=0.006 to 0.050) and ABX (p=0.045 to 0.050) showed lower gutter areas and volumes compared with VBX. In turn, the VBX showed a nonsignificant tendency to decreased compression, especially compared to ABX. Use of the Excluder C3 showed a 6-fold increase in type A1 gutters (related to type Ia endoleak) as compared to the Conformable Excluder (p=0.018). Balloon-expandable stent-grafts (both ABX and VBX) showed a 3-fold increase in type A1 gutters in comparison with self-expanding stent-grafts (p=0.008). Conclusion: The current study suggests that use of the Conformable Excluder in combination with VSE chimney grafts is superior to the other tested CG/MG combinations in terms of gutter size, gutter type, and CG compression.

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Section: Methodsmentioning

confidence: 99%

Gutter Characteristics and Stent Compression of Self-Expanding vs Balloon-Expandable Chimney Grafts in Juxtarenal Aneurysm Models

et al. 2020

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“…The system was primed with 8 L of water‐based media. To mimic the viscosity of human blood (4.4 ± 0.6 cP;), a glycerin solution (44% in distilled water; Roth GmbH, Karlsruhe, Germany) was used. The systemic blood volume of the patient was simulated by a cardiotomy reservoir (Inspire 6F M; Sorin Group S.p.A.).…”

Section: Methodsmentioning

confidence: 99%

Generation of microbubbles in extracorporeal life support and assessment of new elimination strategies

et al. 2019

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Occurrence of microbubbles (MB) is a major problem during venoarterial extracorporeal life support (ECLS) with partially severe clinical complications. The aim of this study was to establish an in vitro ECLS setup for the generation and detection of MB. Furthermore, we assessed different MB elimination strategies. Patient and ECLS circuit were simulated using reservoirs, a centrifugal pump, a membrane oxygenator, and an occluder (modified roller pump). The system was primed with a glycerin solution of 44%. Three different revolution speeds (2500, 3000, and 3400 rpm) were applied. For MB generation, the inflow line of the pump was either statically or dynamically (15 rpm) occluded. A bubble counter was used for MB detection. The effectiveness of the oxygenator and dynamic bubble traps (DBTs) was evaluated in regard to MB elimination capacities. MB generation was highly dependent on negative pressure at the inflow line. Increasing revolution speeds and restriction of the inflow led to increased MB activity. The significant difference between inflow and outflow MB volume identified the centrifugal pump as a main source. We could show that the oxygenator’s ability to withhold larger MB is limited. The application of one or multiple DBTs leads to a significant reduction in MB count and overall gas volume. The application of DBT can significantly reduce the overall gas volume, especially at high flow rates. Moreover, large MB can effectively be broken down for faster absorption. In general, the incidence of MBs is significantly dependent on pump speed and restriction of the inflow. The centrifugal pump was identified as a major source of MB generation.

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“…An Abbe refractometer (Atago USA, Inc., Bellevue, WA) was used to measure the RI of both the PDMS and the BMF. The composition of the BMF was determined based on the recommendations by Yousif et al 49,50 as follows: 47.38% deionized water, 36.94% glycerol, and 15.68% sodium iodide to ensure a match in RI while maintaining a dynamic viscosity similar to that of whole human blood. This BMF exhibits a natural discoloration (yellowing) over time due to the ionization of sodium iodide (releasing I3- ions) after exposure to air or light.…”

Section: Methodsmentioning

confidence: 99%

Computational Fluid Dynamics Modeling of the Human Pulmonary Arteries with Experimental Validation

et al. 2018

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Pulmonary hypertension (PH) is a chronic progressive disease characterized by elevated pulmonary arterial pressure, caused by an increase in pulmonary arterial impedance. Computational fluid dynamics (CFD) can be used to identify metrics representative of the stage of PH disease. However, experimental validation of CFD models is often not pursued due to the geometric complexity of the model or uncertainties in the reproduction of the required flow conditions. The goal of this work is to validate experimentally a CFD model of a pulmonary artery phantom using a particle image velocimetry (PIV) technique. Rapid prototyping was used for the construction of the patient-specific pulmonary geometry, derived from chest computed tomography angiography images. CFD simulations were performed with the pulmonary model with a Reynolds number matching those of the experiments. Flow rates, the velocity field, and shear stress distributions obtained with the CFD simulations were compared to their counterparts from the PIV flow visualization experiments. Computationally predicted flow rates were within 1% of the experimental measurements for three of the four branches of the CFD model. The mean velocities in four transversal planes of study were within 5.9 to 13.1% of the experimental mean velocities. Shear stresses were qualitatively similar between the two methods with some discrepancies in the regions of high velocity gradients. The fluid flow differences between the CFD model and the PIV phantom are attributed to experimental inaccuracies and the relative compliance of the phantom. This comparative analysis yielded valuable information on the accuracy of CFD predicted hemodynamics in pulmonary circulation models.

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Deriving a blood-mimicking fluid for particle image velocimetry in sylgard-184 vascular models

Cited by 27 publications

References 18 publications

Gutter Characteristics and Stent Compression of Self-Expanding vs Balloon-Expandable Chimney Grafts in Juxtarenal Aneurysm Models

Gutter Characteristics and Stent Compression of Self-Expanding vs Balloon-Expandable Chimney Grafts in Juxtarenal Aneurysm Models

Generation of microbubbles in extracorporeal life support and assessment of new elimination strategies

Computational Fluid Dynamics Modeling of the Human Pulmonary Arteries with Experimental Validation

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