Dérivés arylés et éthoxycarbonylés de 3,4-dihydro 2H pyrrole, 2H pyrrole et pyrrole immunoactifs sur le lymphocyte T humain

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

“…In this case, the nitrile group remains in the products and 3,5-disubstituted pyrrole-2-carbonitriles 10 are obtained. Tsuge et al reported the oxidation of pyrroline-3-carboxylates with chloranil [ 45 ] while pyrrole-2-carboxylates were obtained from the oxidation of pyrroline-2-carboxylate with chloranil [ 46 – 47 ] or DDQ [ 48 ]. Different oxidants were screened for the oxidation of cyanopyrroline 6a to pyrrole 10a and the results were judged by TLC.…”

Stereoselective synthesis of Δ(1)-pyrroline sulfonamides via a chiral aldehyde mediated cascade reaction

“…On the other hand, optically active Δ(1)-pyrroline is a type of important molecule that is widely found in bioactive compounds and used as an intermediate for the synthesis of pharmacologically active molecules. 2 In this scenario, the combination of these two key motifs (primary sulfonamide and Δ(1)-pyrroline) will provide potential candidates for drug screening and discovery.…”