Derived equations are not precise enough to predict the adequacy of creatinine clearance in peritoneal dialysis patients

Comparison between creatinine-based equations for estimating total creatinine clearance in peritoneal dialysis: a multicentre study

“…A formula for estimating renal CrCL or the glomerular filtration rate (GFR) in uraemic patients is theoretically capable of predicting totCrCL in PD. Many such equations have been developed [4][5][6][7][8][9][10][11][12][13][14][15], but they have seldom been tested in PD patients in terms of their power to estimate their total CrCL (totCrCL) [16][17][18].…”

Chronic Kidney Disease Epidemiology Collaboration Equation Accuracy in Predicting Peritoneal Dialysis-Delivered Creatinine Clearance

“…Their comparative performances have been assessed in numerous studies and in various populations, with the majority of them showing superiority of the latter in GFR prediction. 3,[8][9][10]16 Generally C-G equation tends to overestimate the effect of age on creatinine excretion and, according to the literature, it is not suitable for predicting MCC in PD patients. 10 Indeed, C-G equation was found to be inaccurate in predicting PD adequacy in a large cohort of Scottish patients 10 and in a multicenter Italian study.…”

“…17 MDRD-4 equation was found to be unreliable in estimating total MCC in a large cohort of Scottish patients, in agreement with our results. 10 Likewise, a recent multicenter Dutch study showed that MDRD-4 was not suitable for GFR estimation in CKD stage 5 patients at the start of dialysis. 17 Generally, MDRD-4 appeared to overestimate true GFR in these studies, a result consistent with ours.…”