Derivatizing agents for spectrophotometric and spectrofluorimetric determination of pharmaceuticals: a review

Vashistha, Vinod Kumar; Bala, R.; Pullabhotla, Viswanadha Srirama Rajasekhar

doi:10.1080/16583655.2023.2206363

Cited by 8 publications

(1 citation statement)

References 95 publications

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“…Spectrometry is widely regarded as an accurate and reliable instrument in pharmaceutical research, especially in routine quality control analysis and uncomplicated matrices analysis, due to its availability, simplicity, short response period, and low expense [13]. Spectrophotometry and spectrofluorimetry techniques are the common and widely distributed spectrometric techniques for quantifying active pharmaceutical ingredients [14–21].…”

Section: Introductionmentioning

confidence: 99%

Study on the interaction between erythrosine B and the cardiac drug amiodarone using fluorescence, scattering, and absorbance spectra and their analytical application

AlSalem,

Alharbi,

Binkadem

et al. 2024

Luminescence

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In an acidic buffered solution, erythrosine B can react with amiodarone to form an association complex, which not only generates great enhancement in resonance Rayleigh scattering (RRS) spectrum of erythrosine B at 346.5 nm but also results in quenching of fluorescence spectra of erythrosine B at λemission = 550.4 nm/λexcitation = 528.5 nm. In addition, the formed erythrosine B–amiodarone complex produces a new absorbance peak at 555 nm. The spectral characteristics of the RRS, absorbance, and fluorescence spectra, as well as the optimum analytical conditions, were studied and investigated. As a result, new spectroscopic methods were developed to determine amiodarone by utilizing erythrosine B as a probe. Moreover, the ICH guidelines were used to validate the developed RRS, photometric, and fluorimetric methods. The enhancements in the absorbance and the RRS intensity and the decrease in the fluorescence intensity of the used probe were proportional to the concentration of amiodarone in ranges of 2.5–20.0, 0.2–2.5, and 0.25–1.75 μg/mL, respectively. Furthermore, limit of detection values were 0.52 ng/mL for the spectrophotometric method, 0.051 μg/mL for the RRS method, and 0.075 μg/mL for the fluorimetric method. Moreover, with good recoveries, the developed spectroscopic procedures were applied to analyze amiodarone in its commercial tablets.

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Section: Introductionmentioning

confidence: 99%

Study on the interaction between erythrosine B and the cardiac drug amiodarone using fluorescence, scattering, and absorbance spectra and their analytical application

AlSalem,

Alharbi,

Binkadem

et al. 2024

Luminescence

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One-pot Microwave Synthesis of Cobalt, Nitrogen, and Sulfur Co-Doped Carbon Quantum Dots for Efficient Monosodium Glutamate Determination in Food Samples

Hamid,

Elagamy,

Gamal

et al. 2024

Food Anal. Methods

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The synthesis of cobalt, nitrogen and sulfur co doped carbon quantum dots (Co-NS-CQDs) has become a subject of significant research interest. These CQDs were produced using a single-step microwave method, which is considered environmentally friendly, and the entire process was completed in just 90 seconds. In this synthesis, citric acid was utilized as the carbon source, methionine served as the source for both nitrogen and sulfur, and cobaltous acetate was used to introduce cobalt ions into the CQDs structure. The synthesized carbon quantum dots (CQDs) exhibit a narrow size distribution and a high quantum yield of 51.5%, which is notably superior to non-metal-doped CQDs with a yield of 38%. Characterization of these CQDs was performed using different techniques such as transmission electron microscopy (TEM), high-resolution TEM (HRTEM), Fourier transformation infrared spectroscopy (FTIR), energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The developed CQDs have blue luminescence at emission wavelength 438 nm after excitation at 350 nm. Different factors affecting the CQDs synthesis including dialysis duration, reaction time and reaction temperature. These CQDs were utilized as a probe for the detection of monosodium glutamate (MSG) in various food products. The intensity of the fluorescence of the CQDs showed a direct and linear increase with the concentration of MSG within the range of 25–250 µg/mL. The detection and quantitation limits for MSG were 2.78 µg/mL and 8.44 µg/mL, respectively. Additionally, the developed method is environmentally friendly, as confirmed by assessments using the analytical Eco scale, Green Analytical Procedure Index (GAPI), and Analytical Greenness calculator (Agree). The proposed method presents several advantages over other reported methods in terms of convenience, rapid response, and attainment of accurate and precise results.

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Development and validation of UV–Vis spectrophotometric method for determination of rivastigmine in PBS and biological matrices: Application to ex vivo permeation profiles and in vivo studies from trilayer dissolving microneedle

Putri,

Ilyas,

Abdullah

et al. 2024

Chemical Data Collections

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Derivatizing agents for spectrophotometric and spectrofluorimetric determination of pharmaceuticals: a review

Cited by 8 publications

References 95 publications

Study on the interaction between erythrosine B and the cardiac drug amiodarone using fluorescence, scattering, and absorbance spectra and their analytical application

Study on the interaction between erythrosine B and the cardiac drug amiodarone using fluorescence, scattering, and absorbance spectra and their analytical application

One-pot Microwave Synthesis of Cobalt, Nitrogen, and Sulfur Co-Doped Carbon Quantum Dots for Efficient Monosodium Glutamate Determination in Food Samples

Development and validation of UV–Vis spectrophotometric method for determination of rivastigmine in PBS and biological matrices: Application to ex vivo permeation profiles and in vivo studies from trilayer dissolving microneedle

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