2010
DOI: 10.18579/jpcrkc/2010/9/1/79469
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Derivatization of Steroids for Obtaining Conjugates: Use as Vectors for Drug Delivery

Abstract: Mono-mode microwave assisted additions of-aminoacids (glycine / valine / phenylalanine) in the presence of K 2 CO 3 to 16 , 17-epoxy-3-hydroxypregnenolone (20) afford corresponding 17?-hydroxy-16-N-carboxyalkylaminosteroids (21a-c) in good yield. Similar conjugate addition of aminoacids to 16-dehydropregnenolone-3-acetate (15), under identical conditions, affords 16-N-carboxyalkylamino steroidal derivatives (22a-c). All the products have been purified chromatographically and characterized spectroscopically. Th… Show more

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Cited by 11 publications
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