Derivatization of honokiol by integrated acetylation and methylation for improved cutaneous delivery and anti-inflammatory potency

Fang, Jia‐You; Huang, Ting‐Hsiang; Hung, Chi‐Feng; Huang, Yu‐Ling; Aljuffali, Ibrahim A.; Liao, Wei-Chun; Lin, Chwan-Fwu

doi:10.1016/j.ejps.2017.12.007

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…The dimethylhonokiol had no change of TEWL and pathological while free honokiol elicited a significant level of TEWL 3 . The same conclusion was found in AMH, long‐term administration of honokiol prompted cutaneous inflammation while AMH did not 49 …”

Section: The Topical Preparations and Safetysupporting

confidence: 66%

“…Fang et al found that 2‐O‐acetyl‐4′‐O‐methylhonokiol (AMH) led to a 10.5‐fold improvement of skin absorption compared with honokiol. The high skin deposition and minimal penetration of AMH make it more conducive to topical administration 49 . In terms of security, the methoxylation of honokiol was relatively non‐toxic toward keratinocytes in vitro.…”

Section: The Topical Preparations and Safetymentioning

confidence: 99%

“…3 The same conclusion was found in AMH, long-term administration of honokiol prompted cutaneous inflammation while AMH did not. 49…”

Section: The Topical Preparations and Safetymentioning

confidence: 99%

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The application prospects of honokiol in dermatology

Liang

Zhou

2022

Dermatologic Therapy

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Honokiol is one of the natural extracts of Magnolia officinalis. It is a small molecule, lipophilic compound with extensive biological effects. It has been used in the treatment of multisystem diseases, including digestive diseases, endocrine diseases, nervous system diseases, and various tumors. This paper reviews the biological effects of honokiol on the treatment of skin diseases in recent years, including antimicrobial, anti-oxidant, anti-inflammatory, anti-tumor, anti-fibrosis, anti-allergy, photo-protection, and immunomodulation. Most current researches are focused on the effects of anti-melanoma and photo-protection. Therefore, we summarized the specific mechanisms about these two effects. On the other side of treating skin diseases, the advantages of topical drugs cannot be replaced. As a small molecule fat-soluble compound, honokiol is suitable for external use. We reviewed the advantages and disadvantages of the topical mixed cream and various improved methods. These improvements include physical and chemical penetration enhancers, drug carriers, and chemical derivatives. In conclusion, honokiol has a wide range of effects, and its topical preparation provides a safe and effective way for treating skin diseases.

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Section: The Topical Preparations and Safetysupporting

confidence: 66%

Section: The Topical Preparations and Safetymentioning

confidence: 99%

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The application prospects of honokiol in dermatology

Liang

Zhou

2022

Dermatologic Therapy

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“…Our skin absorption data showed that topically applied DMD could penetrate the skin, assuring the subsequent anti-AD activity. The cutaneous absorption can be facilitated by the more lipophilic penetrants [21]. DMD revealed a lipophilic characteristic according to a partition coefficient log P of 1.8.…”

Section: Discussionmentioning

confidence: 99%

The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata

Yang

Huang

Chiu

et al. 2018

Journal of Dermatological Science

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“…Moreover, the effects of MH on the cardiovascular system remain poorly understood. Due to its low hydrophilicity, MH exhibits poor pharmacokinetics [8], which may lead to increased accumulation in the organs of the body. Some evidence has suggested beneficial effects of MH, as it has been associated with anti-inflammatory [9], anti-osteoclastogenic, anti-oxidative [10,11], and neuroprotective [12] effects.…”

Section: Introductionmentioning

confidence: 99%

4-O-Methylhonokiol Influences Normal Cardiovascular Development in Medaka Embryo

et al. 2019

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Although 4-O-Methylhonokiol (MH) effects on neuronal and immune cells have been established, it is still unclear whether MH can cause a change in the structure and function of the cardiovascular system. The overarching goal of this study was to evaluate the effects of MH, isolated from Magnolia grandiflora, on the development of the heart and vasculature in a Japanese medaka model in vivo to predict human health risks. We analyzed the toxicity of MH in different life-stages of medaka embryos. MH uptake into medaka embryos was quantified. The LC50 of two different exposure windows (stages 9–36 (0–6 days post fertilization (dpf)) and 25–36 (2–6 dpf)) were 5.3 ± 0.1 μM and 9.9 ± 0.2 μM. Survival, deformities, days to hatch, and larval locomotor response were quantified. Wnt 1 was overexpressed in MH-treated embryos indicating deregulation of the Wnt signaling pathway, which was associated with spinal and cardiac ventricle deformities. Overexpression of major proinflammatory mediators and biomarkers of the heart were detected. Our results indicated that the differential sensitivity of MH in the embryos was developmental stage-specific. Furthermore, this study demonstrated that certain molecules can serve as promising markers at the transcriptional and phenotypical levels, responding to absorption of MH in the developing embryo.

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Derivatization of honokiol by integrated acetylation and methylation for improved cutaneous delivery and anti-inflammatory potency

Cited by 8 publications

References 30 publications

The application prospects of honokiol in dermatology

The application prospects of honokiol in dermatology

The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata

4-O-Methylhonokiol Influences Normal Cardiovascular Development in Medaka Embryo

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