Derivatization-assisted immunoassays: application for group-specific detection of potent methamphetamine and amphetamine enantiomers

Morita, Izumi; Kiguchi, Yuki; Oyama, Hiroyuki; Yamaki, Kouya; Sakio, Nami; Kashiwabara, Keisuke; Kuroda, Yasuhiro; Aya, Ito; Yokota, Asaka; Ikeda, Natsumi; Kikura‐Hanajiri, Ruri; Ueda, Hiroshi; Numazawa, Satoshi; Yoshida, Takemi; Kobayashi, N.

doi:10.1039/d2ay00940d

Cited by 1 publication

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References 44 publications

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“…[ 4 ] Currently, traditional analytical methods for MPEA detection are mainly dependent on advanced spectrum technology and biophysical technology, including chromatography‐mass spectrometry, [ 5 ] electrochemistry, [ 6 ] surface‐enhanced Raman scattering, [ 7 ] quartz crystal microbalance, [ 8 ] and immunoassays. [ 9 ] Although these methods possess high sensitivity and accuracy, most of them are restricted to various intrinsic shortcomings such as bulky equipment, high‐cost, long operation time, and tedious pretreatment of samples. Simultaneously, the low concentration of methamphetamine vapor, often mixed with other gases, leading a significant challenge for real‐time monitoring of methamphetamine due to its ultralow concentration and frequently mixing with other gases.…”

Section: Introductionmentioning

confidence: 99%

Rationally Designed Ionically Conductive Metal‐Organic Frameworks for Ultrasensitive Methamphetamine Analogs Sensor

Xiong,

Li,

Yang

et al. 2024

Adv Funct Materials

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Achieving convenient, sensitive, low‐cost, and non‐contact detection of trace addictive drugs is a challenging problem. Herein, a novel ionically conductive metal‐organic framework (IC‐MOFs) is designed through a controlled interface assembly strategy. The active metal anions are incorporated into the layered MOFs with a porous structure, forming charge carriers that served as effective adsorption/binding sites for N‐methylphenethylamine (MPEA), a crucial simulator of addictive drugs. The in situ integrated Zn3(HHTP)2‐MOF sensor device designed in this study demonstrated real‐time detection of sub‐ppb level MPEA at room temperature, with an exceptionally low theoretical detection limit of 20 ppt. The overall sensing performance of this sensor surpassed all previously reported chemical sensors for detecting methamphetamine. The Zn3(HHTP)2‐MOF sensor exhibited outstanding selectivity, rapid response time (ca. 5 s), excellent long‐term stability, amenable miniaturization, and device consistency. The device successfully passed dual 85 test (500 h at 85 °C and 85% of humidity), which is rarely report previously. Density functional theoretical calculations (DFT) and spectral characterization confirmed that the prominent selectivity of Zn3(HHTP)2‐MOF toward MPEA is attributed to the strong binding ability. The general and straightforward strategy provides brand‐new route to exploiting smart sensors for drug prevention and surveillance.

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Section: Introductionmentioning

confidence: 99%

Rationally Designed Ionically Conductive Metal‐Organic Frameworks for Ultrasensitive Methamphetamine Analogs Sensor

Xiong,

Li,

Yang

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

Derivatization-assisted immunoassays: application for group-specific detection of potent methamphetamine and amphetamine enantiomers

Abstract: Chemical derivatization into larger molecules has generated a monoclonal antibody that enables group-specific immunochemical detection of potent methamphetamine and amphetamine enantiomers.

Cited by 1 publication

References 44 publications

Rationally Designed Ionically Conductive Metal‐Organic Frameworks for Ultrasensitive Methamphetamine Analogs Sensor

Rationally Designed Ionically Conductive Metal‐Organic Frameworks for Ultrasensitive Methamphetamine Analogs Sensor

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