Derivatives of natural amino acids as radioprotectors (review)

Kazaryan, S. A.; Grigoryan, K. P.; Airapetyan, S. N.; Mndzhoyan, O. L.

doi:10.1007/bf02219999

Cited by 3 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compounds containing the 4-[bis(2-chloroethyl)amino]-L-phenylalanyl group are more toxic than the diastereomers with D-configuration of the phenylalanyl fragment, as confirmed by comparison of the data for compounds VIII and V (LDs0 = 300 versus 800 mg/kg) or IXa and VII (LDs0 = 467 versus 1300 mg/kg). Because cytostatic agents are known to produce the radioprotective effect 3 -5 days after the administration [2,7], we have tested the synthesized compounds injected 3 days before the exposure ( Table 3). The maximum radioprotective effect among the compounds studied was observed for salt IXa.…”

Section: Resultsmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and radioprotective properties of 4-[bis(2-chloroethyl)amino]phenylalanyl-L-glutamic acid derivatives

et al. 1997

View full text Add to dashboard Cite

A promising direction in the search for substances possessing radioprotective properties is the synthesis of compounds capable of inhibiting the metabolism of nucleic acids and proteins, in particular, on the basis of natural amino acid derivatives [1,2]. An interesting object for modification is Lglutamic acid which is known to play an important role in the organism. It was reported that some of the glutamic acid derivatives possess radioprotective activity [3,4].The purpose of this work was to synthesize a diethyl ester and salts of a dipeptide of L-glutamic acid with 4-bis(2-chloroethyl)amino]phenylalanine (sarcolysine) and study their radioprotective properties.Diesters were obtained by condensation of N-acetyl-4-[bis(2-chloroethyl)amino]-DL-phenylalanine (I) with the diethyl ester hydrochloride (I) of L-glutamic acid, followed by separation of the resulting diethyl ester of N-acetyl-4-[bis(2- chloroethyl)amino]-DL-phenylalanyl-L-glutamic acid (HI) into diastereomers: diethyl ester of N-acetyl-4-[bis(2-chloroethyl)amino]-L-phenylalanyl-L-glutamic acid (IV) and Nacetyl-4-[bis(2-chloroethyl)amino]-D-phenylalanyl-L-gluta mie acid (V). The corresponding salts (VI and VII) were ob-9 tained by saponification of the ester groups of compounds IV and V with an alkali solution.An important factor is the stereo-purity of the resulting disodium salts of N-acetyl-4-[bis(2-chloroethyl)amino]-Lphenylalanyl-L-glutarnic acid and N-acetyl-4-[bis(2-ehloroethyl)amino]-D-phenylalanyl-L-glutamic acid, which determines the activity of compounds VI and VII. The individual diastereomers IV and V were isolated in analytical amounts by chromatography on a silica gel eohmm.Due to the close chromatographic mobility of the two diastereomers, the method of column chromatography did not

show abstract

Section: Resultsmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

Synthesis and radioprotective properties of 4-[bis(2-chloroethyl)amino]phenylalanyl-L-glutamic acid derivatives

et al. 1997

View full text Add to dashboard Cite

show abstract

“…65,66 Investigations to find noncytotoxic and effective compounds have led to an increasing interest in natural products, including animal venoms. 23,67,68…”

Section: Discussionmentioning

confidence: 99%

“…65,66 Investigations to find noncytotoxic and effective compounds have led to an increasing interest in natural products, including animal venoms. 23,67,68 This investigation tested whether bee venom possesses radioprotective effects against microwave radiation. In previous studies, the venom of Apis mellifera was determined to be radioprotective for X ray and gamma radiation.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective Effects of Honeybee Venom (Apis mellifera) Against 915-MHz Microwave Radiation–Induced DNA Damage in Wistar Rat Lymphocytes: In Vitro Study

Gajski

Garaj‐Vrhovac

2009

Int J Toxicol

View full text Add to dashboard Cite

The aim of this study is to investigate the radioprotective effect of bee venom against DNA damage induced by 915-MHz microwave radiation (specific absorption rate of 0.6 W/kg) in Wistar rats. Whole blood lymphocytes of Wistar rats are treated with 1 microg/mL bee venom 4 hours prior to and immediately before irradiation. Standard and formamidopyrimidine-DNA glycosylase (Fpg)-modified comet assays are used to assess basal and oxidative DNA damage produced by reactive oxygen species. Bee venom shows a decrease in DNA damage compared with irradiated samples. Parameters of Fpg-modified comet assay are statistically different from controls, making this assay more sensitive and suggesting that oxidative stress is a possible mechanism of DNA damage induction. Bee venom is demonstrated to have a radioprotective effect against basal and oxidative DNA damage. Furthermore, bee venom is not genotoxic and does not produce oxidative damage in the low concentrations used in this study.

show abstract

“…It is also shown that because of negative feedback between the Na + /K + -pump activity and cell volume, the Na + /K + pump-induced cell hydration serves as a powerful metabolic mechanism through which the autoregulation of Na + /K +pump activity, as well as regulation of membrane excitability and chemosensitivity are realized [7][8][9]. It is known that the dysfunction of Na + /K + pump leads to activation of Na + /Ca 2+ exchange in the reverse mode (RNa + /Ca 2+ ) as a result of the intracellular Na + ([Na + ]i) increase [10,11].…”

Section: Introductionmentioning

confidence: 99%

Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Brain Cortex Tissues

Narinyan¹,

Ayrapetyan²

2019

EJB

View full text Add to dashboard Cite

The cognitive function of brain and contractility of heart muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and heart muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na + /K + pump and activation of Na + /Ca 2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and heart muscle tissues has different nature. The age-dependent dysfunction of Na + /K + pump-induced activation of RNa + /Ca 2+ exchange leads to dysfunction of heart muscle contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa + /Ca 2+ exchange induced muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues' metabolic control of cell hydration, which leads to overexpression of Na + /Ca 2+ exchanger in the membrane.

show abstract

Derivatives of natural amino acids as radioprotectors (review)

Cited by 3 publications

References 36 publications

Synthesis and radioprotective properties of 4-[bis(2-chloroethyl)amino]phenylalanyl-L-glutamic acid derivatives

Synthesis and radioprotective properties of 4-[bis(2-chloroethyl)amino]phenylalanyl-L-glutamic acid derivatives

Radioprotective Effects of Honeybee Venom (Apis mellifera) Against 915-MHz Microwave Radiation–Induced DNA Damage in Wistar Rat Lymphocytes: In Vitro Study

Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Brain Cortex Tissues

Contact Info

Product

Resources

About

Derivatives of natural amino acids as radioprotectors (review)

Cited by 3 publications

References 36 publications

Synthesis and radioprotective properties of 4-[bis(2-chloroethyl)amino]phenylalanyl-L-glutamic acid derivatives

Synthesis and radioprotective properties of 4-[bis(2-chloroethyl)amino]phenylalanyl-L-glutamic acid derivatives

Radioprotective Effects of Honeybee Venom (Apis mellifera) Against 915-MHz Microwave Radiation–Induced DNA Damage in Wistar Rat Lymphocytes: In Vitro Study

Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na&lt;sup&gt;+&lt;/sup&gt;/Ca&lt;sup&gt;2+&lt;/sup&gt; Exchanger in Brain Cortex Tissues

Contact Info

Product

Resources

About

Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Brain Cortex Tissues