Derivatives of 5,6,11,12-tetrahydrodibenzo[b,f][1,4]diazocine and 5,6,11,12-tetrahydrodibenzo[b,f][1,5]diazocine

Abstract

2-Tetrahydrodibenzo[b.f] [I ,4]diazocine reacts with paraformaldehyde to give the 5,12-endo-methanoderivative : similar bridged compounds were prepared from aromatic aldehydes, but not ketones. The 5.1 2-endomethano-derivative is comparable to Troger's base in its reactions. The synthesis of N-alkyl-5,6,11 , I 2-tetrahydrodibenzo[b,f] [I ,5]diazocines and N-alkyl-5,6,11 ,I 2-tetrahydrodibenzo[b.f] [I ,4]diazocines by direct alkylation and by acylation and subsequent reduction has been investigated. An N-amino-and an NN'-diaminoderivative of the [I ,5]diazocine were prepared.THE synthesis of Troger's base (5,6,11,12-tetrahydro-2,8-dimethyl-5,1 l-ertdo-methanodibenzo[b,fl [ 1,fjldiazocine) (I; R1 = Me, RZ = R3 = H) from p-toluidine and formaldehyde in acid solution, and the extension of this synthesis to analogues, has been described in a number of papers.l Cooper and Partridge synthesised the 5,6,11,12-tetrahydrodibenzolTb,f]jl,5]diazocines (I1 ; R1 = Me or H, R2 = H), and showed that they reacted with aldehydes and certain other carbonyl compounds to give derivatives of the Troger's base type, the product from (11; R1 = Me, R2 = H) and formaldehyde being identical with Troger's base.

Stabilization of rat liver tyrosine aminotransferase by tetracycline

“…Hepatic tyrosine aminotransferase (EC 2.6.1.5) activity is increased by a variety of hormones and pharmacologically unrelated drugs (Lin & Knox, 1957;Greengard & Baker, 1966;Civen et al, 1967;Holten & Kenney, 1967;Granner et al, 1968;Hager & Kenney, 1969;Pal et al, 1969;Mukhtar & Krishna Murti, 1971). Although cortisol, glucagon, adrenaline and insulin are known to increase the rate of enzyme synthesis, the mechanism of increase of tyrosine aminotransferase activity by different drugs is still not unequivocally established.…”