An Ore extension over a polynomial algebra F[x] is either a quantum plane, a quantum Weyl algebra, or an infinite-dimensional unital associative algebra A h generated by elements x, y, which satisfy yxWhen h = 0, the algebras A h are subalgebras of the Weyl algebra A 1 and can be viewed as differential operators with polynomial coefficients. In previous work, we studied the structure of A h and determined its automorphism group Aut F (A h ) and the subalgebra of invariants under Aut F (A h ). Here we determine the irreducible A h -modules. In a sequel to this paper, we completely describe the derivations of A h over any field.