Derivation of risk based wipe surface screening levels for industrial scenarios

May, Lisa M.; Gaborek, Bonnie; Pitrat, Tony; Peters, Laura

doi:10.1016/s0048-9697(01)01117-2

Cited by 16 publications

(2 citation statements)

References 1 publication

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“…Monte-Carlo simulation is a common tool used to incorporate each variable's probability distribution into the estimation of human health risk. 17,26,27 In the current study, Monte-Carlo approach was carried out by running Crystal Ball r 4.0 software. This program calculates risks based on the propagation of variability and uncertainty given by each parameter probability function until a certain number of iterations.…”

Section: Risk Characterisationmentioning

confidence: 99%

Probabilistic human health risk of PCDD/F exposure: a socioeconomic assessment

Nadal

Schuhmacher

Domingo

2004

J. Environ. Monitor.

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The aim of the present study was to assess the human health risks (carcinogenic and non-carcinogenic) of PCDD/F exposure for the adult population living in two different areas (industrial and residential) of Tarragona (Catalonia, Spain), as well as to compare these risks according to the socioeconomic status of the population. Two pathways were considered for PCDD/F exposure: direct (air inhalation, dermal contact and ingestion from soils and dust) and dietary. Although environmental exposure was higher for the population living in the neighborhood of the industrial area (mainly lower socioeconomic group subjects), it only accounted 1.05%. On the other hand, PCDD/F exposure through dietary intake was more important for those individuals of an upper socioeconomic level. This was due to the fact that their diet is richer in those foodstuffs containing higher PCDD/F concentrations. Consequently, taking together direct and dietary exposure to PCDD/Fs, the result is that upper socioeconomic group populations are more exposed to these toxic pollutants. In any case, the current levels of PCDD/F exposure would not mean significant carcinogenic and non-carcinogenic risks for the population living in the industrial and residential areas of Tarragona.

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Section: Risk Characterisationmentioning

confidence: 99%

Probabilistic human health risk of PCDD/F exposure: a socioeconomic assessment

Nadal

Schuhmacher

Domingo

2004

J. Environ. Monitor.

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“…Monte-Carlo simulation. Monte-Carlo simulation is a common approach used to incorporate variability and uncertainty of the parameters mentioned into the estimation of human health exposure (Mari et al, 2009;May et al, 2002;Rovira et al, 2016;Schuhmacher et al, 2001). given by each parameter probability function until a certain number of iterations.…”

Section: Total Dietary Intakementioning

confidence: 99%

Prenatal exposure estimation of BPA and DEHP using integrated external and internal dosimetry: A case study

Martínez

Rovira

Sharma

et al. 2017

Environmental Research

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Prenatal exposure to Endocrine disruptors (EDs), such as Bisphenol A (BPA) and di (2-ethylhexyl) phthalate (DEHP), has been associated with obesity and diabetes diseases in childhood, as well as reproductive, behavioral and neurodevelopment problems. The aim of this study was to estimate the prenatal exposure to BPA and DEHP through food consumption for pregnant women living in Tarragona County (Spain). Probabilistic calculations of prenatal exposure were estimated by integrated external and internal dosimetry modelling, physiologically based pharmacokinetic (PBPK) model, using a Monte-Carlo simulation. Physical characteristic data from the cohort, along with food intake information from the questionnaires (concentrations of BPA and DEHP in different food categories and the range of the different food ratios), were used to estimate the value of the total dietary intake for the Tarragona pregnancy cohort. The major contributors to the total dietary intake of BPA were canned fruits and vegetables, followed by canned meat and meat products. In turn, milk and dairy products, followed by ready to eat food (including canned dinners), were the most important contributors to the total dietary intake of DEHP. Despite the dietary variations among the participants, the intakes of both chemicals were considerably lower than their respective current tolerable daily intake (TDI) values established by the European Food Safety Authority (EFSA). Internal dosimetry estimates suggest that the plasma concentrations of free BPA and the most important DEHP metabolite, mono (2-ethylhexyl) phthalate (MEHP), in pregnant women were characterized by transient peaks (associated with meals) and short half-lives (< 2h). In contrast, fetal exposure was characterized by a low and sustained basal BPA and MEHP concentration due to a lack of metabolic activity in the fetus. Therefore, EDs may have a greater effect on developing organs in young children or in the unborn child.

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Risk assessment before and after solar photocatalytic degradation of BTEX contaminated groundwater at a gas station site in Korea

Cho¹,

Choi

Kang

et al. 2008

Environ. Prog.

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We assessed the incremental lifetime risks due to groundwater contamination with benzene, toluene, ethylbenzene, and xylene compounds (BTEX) for residents living on the site of a former gas station. Five remedial processes were applied to examine the degradation pattern of groundwater samples under similar weather conditions in winter: H2O2/solar light (action 1), immobilized TiO2/solar light (action 2), TiO2 slurry/solar light (action 3), immobilized TiO2/solar light/H2O2 (action 4), and TiO2 slurry/solar light/H2O2 (action 5). None of the remedial actions satisfied the criteria of acceptable risk (1 × 10−6 for carcinogens) using point estimation with both central tendency exposure (CTE) and reasonable maximum exposure (RME) for all pathways via designated exposure scenarios. Regarding the total hazard index (HI) for noncarcinogens, only action 5 satisfied all the exposure scenarios, both CTE and RME, for toluene, ethylbenzene, and xylene compounds, whereas the total health risk for benzene was between 10−5 and 10−6 for carcinogens. Results of probabilistic estimation before and after the treatment of benzene with action 5 using a Monte Carlo simulation were 68.1% for males (95% CI: 5.0 × 10−7 to 3.9 × 10−6) and 74.2% for females (95% CI: 5.0 × 10−7 to 4.6 × 10−6), exceeding the criteria of acceptable risk (10−6 for carcinogens). However, no adverse health risk was posed if remedial action 5 or an increased reaction time were applied. This study is a new attempt to integrate issues of groundwater contamination based on concentration and health risk assessment associated with different ex situ remedial actions. © 2008 American Institute of Chemical Engineers Environ Prog, 2008

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Derivation of risk based wipe surface screening levels for industrial scenarios

Cited by 16 publications

References 1 publication

Probabilistic human health risk of PCDD/F exposure: a socioeconomic assessment

Probabilistic human health risk of PCDD/F exposure: a socioeconomic assessment

Prenatal exposure estimation of BPA and DEHP using integrated external and internal dosimetry: A case study

Risk assessment before and after solar photocatalytic degradation of BTEX contaminated groundwater at a gas station site in Korea

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