Derivation of functional thymic epithelial organoid lines from adult murine thymus

Lim, Sangho; J. F. van Son, Gijs; Wisma Eka Yanti, Ni Luh; Andersson-Rolf, Amanda; Willemsen, Sam; Korving, Jeroen; Lee, Hong-Gyun; Begthel, Harry; Clevers, Hans

doi:10.1016/j.celrep.2024.114019

Cell Reports

2024

DOI: 10.1016/j.celrep.2024.114019

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Derivation of functional thymic epithelial organoid lines from adult murine thymus

Sangho Lim,

Gijs J. F. van Son,

Ni Luh Wisma Eka Yanti

et al.

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2024

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Cited by 1 publication

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Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives

Müller,

Loskutov,

Küffer

et al. 2024

Cancers

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Cell culture model systems are fundamental tools for studying cancer biology and identifying therapeutic vulnerabilities in a controlled environment. TET cells are notoriously difficult to culture, with only a few permanent cell lines available. The optimal conditions and requirements for the ex vivo establishment and permanent expansion of TET cells have not been systematically studied, and it is currently unknown whether different TET subtypes require different culture conditions or specific supplements. The few permanent cell lines available represent only type AB thymomas and thymic carcinomas, while attempts to propagate tumor cells derived from type B thymomas so far have been frustrated. It is conceivable that epithelial cells in type B thymomas are critically dependent on their interaction with immature T cells or their three-dimensional scaffold. Extensive studies leading to validated cell culture protocols would be highly desirable and a major advance in the field. Alternative methods such as tumor cell organoid models, patient-derived xenografts, or tissue slices have been sporadically used in TETs, but their specific contributions and advantages remain to be shown.

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Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives

Müller,

Loskutov,

Küffer

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

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Derivation of functional thymic epithelial organoid lines from adult murine thymus

Cited by 1 publication

References 81 publications

Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives

Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives

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