Derivation of an oral reference dose (RfD) for di 2-ethylhexyl cyclohexan-1,4-dicarboxylate (DEHCH), an alternative to phthalate plasticizers

Richardson, Brianna; Cox, K.; Bhat, Virunya S.

doi:10.1016/j.yrtph.2017.11.010

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Medical device manufacturers were therefore forced to quickly find alternatives to DEHP to maintain the elasticity of PVC nutrition tubes, infusion sets, and hemodialysis lines. Several replacement plasticizers, the so-called alternative to DEHP plasticizers such as tri-octyl trimellitate (TOTM), 1,2-cyclohexane dicarboxylic acid diisononylester (DINCH), and di(2-ethylhexyl)cyclohexan-1,4-dicarboxylate (DEHCH), are currently incorporated in modern medical devices [84–86].…”

Section: Exposure Sources and Regulationmentioning

confidence: 99%

Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review

Ito

Kamijima

Nakajima

2019

Environ Health Prev Med

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The plasticizer di(2-ethylhexyl) phthalate (DEHP) has been widely used in the manufacture of polyvinyl chloridecontaining products such as medical and consumer goods. Humans can easily be exposed to it because DEHP is ubiquitous in the environment. Recent research on the adverse effects of DEHP has focused on reproductive and developmental toxicity in rodents and/or humans. DEHP is a representative of the peroxisome proliferators. Therefore, peroxisome proliferator-activated receptor alpha (PPARα)-dependent pathways are the expected mode of action of several kinds of DEHP-induced toxicities. In this review, we summarize DEHP kinetics and its mechanisms of carcinogenicity and reproductive and developmental toxicity in relation to PPARα. Additionally, we give an overview of the impacts of science policy on exposure sources.

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Section: Exposure Sources and Regulationmentioning

confidence: 99%

Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review

Ito

Kamijima

Nakajima

2019

Environ Health Prev Med

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“…Bis(2-ethylhexyl) terephthalate (DEHT) and DEHP have more toxicity as compared to DEHT and do not show any effect over production, genotoxicity, carcinogenicity and seem to be protective in the applications of infusion tubing stump [67][68][69][70][71]. Di(2-ethylhexyl) -1,2-cyclohexane dicarboxylate (DEHCH) was studied over SD rats for reproductive and developmental studies by a researcher [72]. Conclusively, it was reported that DEHCH posed a minimal effect over spleen.…”

Section: Exposure Studymentioning

confidence: 99%

Leaching and Exposure of Phthalates From Medical Devices; Health Impacts and Regulations

Hab¹,

Talpur²,

Baig³

et al. 2019

Env.cont.Reviews

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Phthalates (PAEs) are widely used as plasticizers in medical devices to make polyvinyl chloride flexible and soft. However, PAEs can be leached out from plasticizers undesirably and can migrate within the material and end up with direct exposure to humans. Therefore, a number of studies have been conducted globally focusing on their leaching from medical devices like blood bags, infusion tubing, peritoneal dialysis bags and tubing, catheters etc. In current review an attempt is made to gather information related to leaching, exposure, health implication of PAEs along with the regulation used in different countries. Toxic health effects with the exposure of PAEs includes neurological effects, DNA damage, oxidative stress, asthma with negative impact on lungs, effects on reproductive system, liver impairment and gastrointestinal effects. In addition, leaching studies has shown the presence of DEHP about 31-34 % in peritoneal dialysis set like bags and tubing. DEHP leached out from medical apparatus depends upon temperature, storage time, amount of DEHP present in devices and shaking of device while in touched with medical solution. The exposure of plasticizers for pregnant hospitalised women and infants has also highlighted. In addition, PAEs alternates introduced in market are also discussed like Trioctyltrimellitate/tri-(2-ethylhexyl) trimellitate) along with various regulations regarding the use of PAEs in medical devices and other products. was poor.

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“…The two main traditional methods for calculating RfD are the NOAEL/LOAEL method and the benchmark dose method (BMDL) [5,6], and the RfD value is derived by the uncertainty factor UF and the correction factor MF by these traditional methods [7]. These derivation methods require a large investment of time for exposure experiments on mammals [8][9][10]. Since the U.S. EPA issued risk assessment guidelines in the 1980s, RfD values have been obtained for only a few hundred chemical substances [2], so the traditional methods for obtaining RfD are inefficient and constrain the health risk assessment studies of chemical substances.…”

Section: Introductionmentioning

confidence: 99%

The Application of Reference Dose Prediction Model to Human Health Water Quality Criteria and Risk Assessment

Men

Xie

Zhao

et al. 2023

Toxics

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Oral reference dose (RfD) is a key parameter for deriving the human health ambient water quality criteria (AWQC) for non-carcinogenic substances. In this study, a non-experimental approach was used to calculate the RfD values, which explore the potential correlation between toxicity and physicochemical characteristics and the chemical structure of pesticides. The molecular descriptors of contaminants were calculated using T.E.S.T software from EPA, and a prediction model was developed using a stepwise multiple linear regression (MLR) approaches. Approximately 95% and 85% of the data points differ by less than 10-fold and 5-fold between predicted values and true values, respectively, which improves the efficiency of RfD calculation. The model prediction values have certain reference values in the absence of experimental data, which is beneficial to the advancement of contaminant health risk assessment. In addition, using the prediction model constructed in this manuscript, the RfD values of two pesticide substances in the list of priority pollutants are calculated to derive human health water quality criteria. Furthermore, an initial assessment of the health risk was performed by the quotient value method based on the human health water quality criteria calculated by the prediction model.

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Derivation of an oral reference dose (RfD) for di 2-ethylhexyl cyclohexan-1,4-dicarboxylate (DEHCH), an alternative to phthalate plasticizers

Cited by 8 publications

References 9 publications

Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review

Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review

Leaching and Exposure of Phthalates From Medical Devices; Health Impacts and Regulations

The Application of Reference Dose Prediction Model to Human Health Water Quality Criteria and Risk Assessment

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