1991
DOI: 10.1128/mcb.11.9.4324-4332.1991
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Derepression of Mouse β-Major-Globin Gene Transcription during Erythroid Differentiation

Abstract: Functional analysis of the mouse beta-major-globin gene promoter has revealed a negative regulatory element (-100 to -250 bp) which represses promoter activity in mouse erythroleukemia (MEL) cells. Promoter activity is induced 14-fold during terminal differentiation of MEL cells. Three major in vitro binding sites for NF1 (-250 bp), GATA-1 (-212 bp), and a sequence at -165 bp (BB1) have been defined in this region. Site-directed mutagenesis of any one of the three sites resulted in a five- to sixfold up-regula… Show more

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Cited by 4 publications
(1 citation statement)
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“…KU70 and KU80 make up a heterodimer that is a major enzyme involved in DNA damage repair and the maintenance of telomere length. Mice homozygous for KU70 mutations are very sensitive to ionizing radiation [48], and mice lacking the KU70 or KU80 gene are characterized by premature aging [49]. Therefore, it has been argued that double-strand DNA breaks contribute to aging, and it is known that DNA damage repair is reduced in the AD brain [50].…”
Section: Discussionmentioning
confidence: 99%
“…KU70 and KU80 make up a heterodimer that is a major enzyme involved in DNA damage repair and the maintenance of telomere length. Mice homozygous for KU70 mutations are very sensitive to ionizing radiation [48], and mice lacking the KU70 or KU80 gene are characterized by premature aging [49]. Therefore, it has been argued that double-strand DNA breaks contribute to aging, and it is known that DNA damage repair is reduced in the AD brain [50].…”
Section: Discussionmentioning
confidence: 99%