Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases

Cisa‐Wieczorek, Sabina; Hernández‐Álvarez, María Isabel

doi:10.3390/cells9122605

Cited by 21 publications

(14 citation statements)

References 113 publications

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“…M1 macrophages and M2 macrophages are considered to preferentially trigger Th1-type and Th2-type responses ( 13 , 14 ), representing proinflammatory and anti-inflammatory polarization states, respectively. These classifications show that macrophages exist on a continuum, and macrophage phenotype can be better described as a series of grades over a wide range ( 15 ). Therefore, macrophages are further divided into M2a, M2b, M2c and M2d according to the molecules that lead to the activation of M2 macrophages and their gene expression profiles ( 16 ).…”

Section: Origin and Physiological Function Of Skin Macrophagesmentioning

confidence: 99%

Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin

et al. 2022

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Macrophages, the main immune cells in the skin, form an innate immune barrier. Under physiological conditions, skin maintains immune barrier function through macrophage phagocytosis and antigen presentation. Parenchymal and stromal cell regeneration plays an important role in skin injury repair and uses macrophage plasticity to influence and stabilize the skin microenvironment. Diabetic skin lesions are the most common diabetes complication and are involved in the early pathophysiology of diabetic foot. Therefore, studying the initial link in diabetic skin lesions is a research hot spot in the early pathogenesis of diabetic foot. Skin inflammation caused by hyperglycaemia, oxidative stress and other injuries is an important feature, but the specific mechanism is unknown. Recent studies have suggested that chronic inflammatory injury is widely involved in a variety of skin diseases, and whether it plays an important role in diabetic skin lesions is unclear. In this review, current research hotspots were combined with the pathogenesis of diabetic skin lesions and analysed from the perspectives of the physiological function of skin macrophages, the impairment of skin macrophages in diabetes, and the mechanism of chronic inflammatory injury in macrophages to provide a theoretical basis for early screening and evaluation of diabetic foot.

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Section: Origin and Physiological Function Of Skin Macrophagesmentioning

confidence: 99%

Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin

et al. 2022

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“…Their derivatives can act as important signaling molecules to regulate cellular function [ 2 ]. However, dysregulation of fatty acid and cholesterol metabolism can cause various metabolic diseases, i.e., obesity, fatty liver, atherosclerosis, neutral lipid storage disease (NLSD), and cholesterol storage disease (CESD) [ 3 , 4 ]. Increasing evidence shows that lipid alterations also accelerate neurodegenerative disease progression by promoting oligomerization of pathogenic proteins and brain inflammation [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage

2022

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Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options, novel therapies are desperately needed. Recent studies have shown that GBM acquires large amounts of lipids for rapid growth through activation of sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor that regulates fatty acid and cholesterol synthesis, and cholesterol uptake. Interestingly, GBM cells divert substantial quantities of lipids into lipid droplets (LDs), a specific storage organelle for neutral lipids, to prevent lipotoxicity by increasing the expression of diacylglycerol acyltransferase 1 (DGAT1) and sterol-O-acyltransferase 1 (SOAT1), which convert excess fatty acids and cholesterol to triacylglycerol and cholesteryl esters, respectively. In this review, we will summarize recent progress on our understanding of lipid metabolism regulation in GBM to promote tumor growth and discuss novel strategies to specifically induce lipotoxicity to tumor cells through disrupting lipid storage, a promising new avenue for treating GBM.

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“…Lipid metabolism plays a central role in maintaining the normal homeostasis of the human body. Aberration of lipid metabolism is a trigger for chronic diseases, including diabetes, neurological disorders, cancer, and cardiovascular disease (CVD) [ 1 , 2 , 3 ]. Traditionally, screening among asymptomatic individuals for lipid disorders rests on consideration of age, gender, blood pressure, smoking status, and testing for cholesterol, triglycerides, and glucose levels in plasma.…”

Section: Introductionmentioning

confidence: 99%

Integrated Quantitative Targeted Lipidomics and Proteomics Reveal Unique Fingerprints of Multiple Metabolic Conditions

et al. 2022

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Aberrations in lipid and lipoprotein metabolic pathways can lead to numerous diseases, including cardiovascular disease, diabetes, neurological disorders, and cancer. The integration of quantitative lipid and lipoprotein profiling of human plasma may provide a powerful approach to inform early disease diagnosis and prevention. In this study, we leveraged data-driven quantitative targeted lipidomics and proteomics to identify specific molecular changes associated with different metabolic risk categories, including hyperlipidemic, hypercholesterolemic, hypertriglyceridemic, hyperglycemic, and normolipidemic conditions. Based on the quantitative characterization of serum samples from 146 individuals, we have determined individual lipid species and proteins that were significantly up- or down-regulated relative to the normolipidemic group. Then, we established protein–lipid topological networks for each metabolic category and linked dysregulated proteins and lipids with defined metabolic pathways. To evaluate the differentiating power of integrated lipidomics and proteomics data, we have built an artificial neural network model that simultaneously and accurately categorized the samples from each metabolic risk category based on the determined lipidomics and proteomics profiles. Together, our findings provide new insights into molecular changes associated with metabolic risk conditions, suggest new condition-specific associations between apolipoproteins and lipids, and may inform new biomarker discovery in lipid metabolism-associated disorders.

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Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases

Cited by 21 publications

References 113 publications

Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin

Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin

Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage

Integrated Quantitative Targeted Lipidomics and Proteomics Reveal Unique Fingerprints of Multiple Metabolic Conditions

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