Deregulated miRNAs in osteoporosis: effects in bone metastasis

Bellavia, Daniele; Salamanna, Francesca; Raimondi, Lavinia; Luca, Angela De; Carina, Valeria; Costa, Viviana; Alessandro, Riccardo; Fini, Milena; Giavaresi, G.

doi:10.1007/s00018-019-03162-w

Cited by 47 publications

(42 citation statements)

References 124 publications

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“…miR‐29b is a miRNA that regulates both osteoblastogenesis and osteoclastogenesis . Furthermore, serum miR‐29b is down‐regulated in PCa patients and this increases the formation of osteolytic lesions, influencing osteoblast and osteoclast differentiation and activities . These results suggested that overexpression in serum of circFOXO3 could influence osteolytic lesions formation through these processes in PCa.…”

Section: Discussionmentioning

confidence: 95%

Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR‐29a‐3p

Kong

Wan

et al. 2019

J Cellular Molecular Medi

109

103

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Circular RNA FOXO3 (CircFOXO3, also termed as Hsa_circ_0006404) is derived from exon 2 of forkhead box O3 (FOXO3) gene, and abnormal expression is shown in different diseases. However, whether circFOXO3 plays important roles in tumorigenesis and progression of prostate cancer (PCa) remains unclear. In this study, we found that circFOXO3 was up‐regulated in both PCa tissues and serum samples. Moreover, circFOXO3 was positively correlated with the Gleason score in PCa samples. CircFOXO3 was observed to be up‐regulated in Gleason score > 6 PCa samples compared with Gleason score = 6 PCa samples. Knock‐down circFOXO3 could remarkably inhibit PCa cell cycle, proliferation and promote cell apoptosis in vitro. Furthermore, we demonstrated circFOXO3 could act as miR‐29a‐3p sponge to up‐regulate SLC25A15 expression by bioinformatics analysis, dual‐luciferase reporter assays and biotinylated RNA pull‐down assays. SLC25A15 could reverse the tumour suppressing roles of knock‐down circFOXO3 in PCa. Of note, we found that miR‐29a‐3p was down‐regulated; however, SLC25A15 was overexpressed in PCa samples compared with normal tissues. In conclusion, circFOXO3 acts as a miR‐29a‐3p sponge to exhibit oncogenic activity that affects the cell cycle and cell apoptosis in PCa through transcriptional up‐regulation of SLC25A15. Our analysis suggests circFOXO3 could act as promising prostate cancer biomarkers.

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Section: Discussionmentioning

confidence: 95%

Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR‐29a‐3p

Kong

Wan

et al. 2019

J Cellular Molecular Medi

109

103

View full text Add to dashboard Cite

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“…In the last few years, the increasing amount of information acquired about the biology of cancer cells and the molecular mechanisms that govern the onset and progression of the tumor has allowed the development of new drugs [40,41]. However, the high mortality rate in subjects with CRC and the increased risk of metastases, including distant bone metastases with subsequent complications such as pain and pathological fractures due to bone destruction [42,43], indicate the need of more effective and targeted therapies, especially for the treatment of metastatic colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-Induced miR-675-5p Supports β-Catenin Nuclear Localization by Regulating GSK3-β Activity in Colorectal Cancer Cell Lines

Saieva

Barreca

Zichittella

et al. 2020

IJMS

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The reduction of oxygen partial pressure in growing tumors triggers numerous survival strategies driven by the transcription factor complex HIF1 (Hypoxia Inducible Factor-1). Recent evidence revealed that HIF1 promotes rapid and effective phenotypic changes through the induction of non-coding RNAs, whose contribution has not yet been fully described. Here we investigated the role of the hypoxia-induced, long non-coding RNA H19 (lncH19) and its intragenic miRNA (miR-675-5p) into HIF1-Wnt crosstalk. During hypoxic stimulation, colorectal cancer cell lines up-regulated the levels of both the lncH19 and its intragenic miR-675-5p. Loss of expression experiments revealed that miR-675-5p inhibition, in hypoxic cells, hampered β-catenin nuclear localization and its transcriptional activity, while lncH19 silencing did not induce the same effects. Interestingly, our data revealed that miRNA inhibition in hypoxic cells restored the activity of Glycogen Synthase Kinase 3β (GSK-3β) reducing the amount of P-Ser9 kinase, thus unveiling a role of the miR-675-5p in controlling GSK-3β activity. Bioinformatics analyses highlighted the serine/threonine-protein phosphatases PPP2CA, responsible for GSK-3β activation, among the miR-675-5p targets, thus indicating the molecular mediator through which miR-675-5p may control β-catenin nuclear localization. In conclusion, here we demonstrated that the inhibition of the hypoxia-induced non-coding RNA miR-675-5p hampered the nuclear localization of β-catenin by regulating GSK-3β activity, thus proposing the miR-675-5p as a new therapeutic target for the treatment of colorectal cancer.

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“…Effects of miR-based therapy have been investigated in the context of the BM microenvironment [134] and bone disease (BD) [135]. Specifically, replacement of miR-29b in osteoclasts prevented bone resorption by reducing expression of c-FOS and MMP2 [136].…”

Section: Sncrnasmentioning

confidence: 99%

The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

Morelli

Gullà

Rocca

et al. 2020

Cancers

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Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.

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Deregulated miRNAs in osteoporosis: effects in bone metastasis

Cited by 47 publications

References 124 publications

Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR‐29a‐3p

Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR‐29a‐3p

Hypoxia-Induced miR-675-5p Supports β-Catenin Nuclear Localization by Regulating GSK3-β Activity in Colorectal Cancer Cell Lines

The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

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