Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis

Gao, Wen; Yu, Yue; Cao, Hailong; Shen, Hua; Li, Xiaodong; Pan, Shiyang; Shu, Yongqian

doi:10.1016/j.biopha.2010.01.018

Cited by 232 publications

(189 citation statements)

References 58 publications

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“…It has been reported that miR-143 is downexpressed in colon (15), lung (16) and prostate cancer (17) and is overexpressed in hepatocarcinoma (18). Furthermore, miR-143 is involved in the regulation of MYO6 expression in prostate cancer (17); extracellular signal-regulated kinase-5 (ERK-5) is a miR-143 target in prostate cancer and miR-143 inhibits the proliferation at least in part by the inhibition of ERK-5 activity (19).…”

Section: Discussionmentioning

confidence: 99%

miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2

Liu

Guo

et al. 2011

Mol Med Report

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Section: Discussionmentioning

confidence: 99%

miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2

Liu

Guo

et al. 2011

Mol Med Report

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“…The identification of microRNAs (miRNAs) has opened a new avenue for developing highly reliable diagnostic and prognostic biomarkers to facilitate the early diagnosis of NSCLC and predict the clinical outcomes of patients (3,4). At present, numerous single miRNAs, including let-7a-2 (5), miRNA-146b (6), miRNA-155 (5,6), miRNA-31 (7), miRNA-374a (8), miRNA-451 (9) and miRNA-21 (10,11) have been reported to be associated with the tumorigenesis and progression of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Identification of microRNA-615-3p as a novel tumor suppressor in non-small cell lung cancer

Zhang

et al. 2017

Oncology Letters

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Abstract. Lung cancer is the most frequent cause of mortality in cancer patients; non-small-cell lung cancer (NSCLC) accounts for ~80% of lung cancer cases. MicroRNAs (miRNAs) have been revealed to perform an important role in cancer development and progression. Based on a custom miRNA microarray analysis of patients with NSCLC, miRNA-615-3p (miR-615-3p) downregulation was identified in NSCLC tissues compared with normal lung tissues, which suggested that miR-615-3p acted as a tumor suppressor in lung cancer. The overexpression of miR-615-3p was then validated using 40 pairs of NSCLC and adjacent normal tissue samples using a TaqMan reverse transcription-quantitative polymerase chain reaction assay. In order to investigate the tumor suppressor function of miR-615-3p, the ectopic expression of miR-615-3p in the NSCLC A549, H1299 and H1650 cell lines was established. The results revealed that overexpressed miR-615-3p markedly inhibited cell proliferation and colony formation in the 3 NSCLC cell lines compared with the cells overexpressing the negative control sequence (NC). Additional investigation revealed that miR-615-3p overexpression significantly induced apoptosis and cell cycle arrest at the G1 phase in the A549, H1299 and H1650 cell lines compared with the cells overexpressing NC. Finally, ectopic expression of miR-615-3p was found to repress the cell migration and invasion of the 3 lung cancer cell lines. The results of the present study demonstrate, for the first time, that miR-615-3p functions as a tumor suppressor in NSCLC, and may be a novel potential molecular therapeutic target for patients with NSCLC.

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“…miR-181a acts as an intrinsic antigen sensitivity ''rheostat'' in T cells. Abnormally low miR-181a expression was reported in patients with acute myeloid leukemia, chronic lymphocytic leukemia, non-small cell lung cancer, adult T-cell leukemia, and glioblastoma [24][25][26][27][28]. Additionally, miR181a displays tumor suppressive effects against oral squamous cell carcinoma and glioma cells by suppressing cell proliferation [29,30].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

et al. 2012

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Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis

Cited by 232 publications

References 58 publications

miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2

miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2

Identification of microRNA-615-3p as a novel tumor suppressor in non-small cell lung cancer

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

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