Der wundheilende Effekt einer Symphytum-Herba-Extrakt-Creme (Symphytum × uplandicum Nyman): Ergebnisse einer randomisierten, kontrollierten Doppelblindstudie

Barna, M; Kucera, Alexander; Hladícova, Marie; Kučera, Miroslav

doi:10.1007/s10354-007-0474-y

Cited by 39 publications

(32 citation statements)

References 6 publications

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“…Table 5 Reporting quality of S. x uplandicum trials. Barna (2012) 44 Barna (2007) 43 Kucera (2005) 46 Kucera (2004) 45 Mayer (1993) 54 Mayer (1991) 55 Niedner (1989) uncritical and sparse. Tables 4-6 detail the level of reporting for each item in each trial according to species (note that Petersen et al 51 was a conference abstract and so only reporting for title and abstract could be assessed).…”

Section: Resultsmentioning

confidence: 97%

A critical scoping review of external uses of comfrey (Symphytum spp.)

Frost

MacPherson

O’Meara

2013

Complementary Therapies in Medicine

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Section: Resultsmentioning

confidence: 97%

A critical scoping review of external uses of comfrey (Symphytum spp.)

Frost

MacPherson

O’Meara

2013

Complementary Therapies in Medicine

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“…One study comparing a 10% comfrey cream and a 1% reference cream found that those applying the 10% cream for 2 to 3 days showed clinically significant faster reduction of wound size over the reference cream. 18 Kuceara et al 19 found that a concentration of 10% comfrey cream significantly improved back pain on activity, at rest, and during palpation over a 1% reference cream and concluded that the results confirmed known anti-inflammatory and analgesic effects of topical comfrey. More recently, clinical studies have shown comfrey to be therapeutically beneficial for neuromuscular conditions.…”

Section: Introductionmentioning

confidence: 95%

“…Similar previous studies have used reference creams in pseudoplacebo comparisons. 18,19 For the present study, the placebo/reference cream was eucalyptus oil, which has been shown to be absorbed readily through the skin. 34 Eucalyptus oil contains α-pinene and 1,8-cineole and demonstrates strong radical scavenging activity as an antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials

Smith

Jacobson

2011

Journal of Chiropractic Medicine

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Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials The purpose of this study was to determine the effect of 2 concentrations of topical, comfrey-based botanical creams containing a blend of tannic acid and eucalyptus to a eucalyptus reference cream on pain, stiffness, and physical functioning in those with primary osteoarthritis of the knee. Methods: Forty-three male and female subjects (45-83 years old) with diagnosed primary osteoarthritis of the knee who met the inclusion criteria were entered into the study. The subjects were randomly assigned to 1 of 3 treatment groups: 10% or 20% comfrey root extract (Symphytum officinale L.) or a placebo cream. Outcomes of pain, stiffness, and functioning were done on the Western Ontario and MacMaster Universities Osteoarthritis Index. Participants applied the cream 3× a day for 6 weeks and were evaluated every 2 weeks during the treatment. Results: Repeated-measures analyses of variance yielded significant differences in all of the Western Ontario and MacMaster Universities Osteoarthritis Index categories (pain P b .01, stiffness P b .01, daily function P b .01), confirming that the 10% and 20% comfrey-based creams were superior to the reference cream. The active groups each had 2 participants who had temporary and minor adverse reactions of skin rash and itching, which were rapidly resolved by modifying applications. Conclusion: Both active topical comfrey formulations were effective in relieving pain and stiffness and in improving physical functioning and were superior to placebo in those with primary osteoarthritis of the knee without serious adverse effects.

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“…Parenteral application of growth hormones resulted in accelerated healing of large cutaneous burns in children [4]. Three days of acceleration with comfrey extract were reported for abrasion wound healing [7] and 4.7 days were reported for honey dressings in partial-thickness burns [8], while aloe vera did not significantly reduce the healing times for burns but did reduce the healing times of hemorrhoidectomy [9]. For the popular active ingredient dexpanthenol [30], no clinical study results are available.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical investigations have been performed comparing different types of wound dressings as well as metabolic supplementation [3], growth hormones [4], physical measures like extracorporeal shock waves [5,6], and traditionally used natural topical wound healing substances like comfrey, honey, or aloe vera [7,8,9]. However, to date, no generally accepted treatment exists for surgical superficial wounds such as those present at STSG donor sites, as no treatment with proven acceleration of superficial wound healing is available.…”

Section: Introductionmentioning

confidence: 99%

Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions

Metelmann

Brandner

Schumann

et al. 2014

Skin Pharmacol Physiol

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The acceleration of wound healing is a major surgical concern. A triterpene extract from birch bark (Betulae cortex) experimentally enhances keratinocyte differentiation in vitro and accelerates wound healing ex vivo. We conducted an open, blind-evaluated, controlled, prospective, randomized (1:1) phase II clinical trial in patients requiring split-thickness skin graft transplantation at two university hospitals in Germany. Donor sites on the upper legs were covered with a moist silicone-coated dressing. Oleogel-S10 ointment containing 10% birch bark extract was randomly applied to the distal or proximal half of the wound, with the other half serving as an intraindividual control, for 14 days after the skin graft surgery. The primary efficacy variable was faster reepithelialization as determined from macrophotographs by independent, blinded experts. Twenty-four patients were randomized and completed the trial. After the 14-day test period, the planned interim analysis revealed a highly significant (p 0.0001) superiority of Oleogel-S10 in the primary efficacy variable and the trial was terminated early due to ethical concerns. The treatment side was also better reepithelialized and more similar to normal skin after 3 months. In conclusion, Oleogel-S10 significantly accelerated reepithelialization at split-thickness skin graft donor sites. Treatment with Oleogel-S10 was safe and well tolerated. i 2014 S. Karger AG, Basel

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Der wundheilende Effekt einer Symphytum-Herba-Extrakt-Creme (Symphytum × uplandicum Nyman): Ergebnisse einer randomisierten, kontrollierten Doppelblindstudie

Abstract: Symphytum herb extract can be attributed distinct wound healing effects, effects that can explicitly be used in paediatry.

Cited by 39 publications

References 6 publications

A critical scoping review of external uses of comfrey (Symphytum spp.)

A critical scoping review of external uses of comfrey (Symphytum spp.)

Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials

Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions

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