Der Wirkungsmechanismus von wässrigem Torfextrakt auf die spontane kontraktile Aktivität der glatten Muskulatur

Am, Beer; Lukanov, J; Sagorchev, P.

doi:10.1159/000021358

Cited by 19 publications

(7 citation statements)

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“…3, below). These effects are analogous both in character and in mechanism of action to the effect of the water peat extract on SCA of SMS [2]. The only difference is the magnitude of the contractile activity, which is several times higher for water peat extract.…”

Section: Discussionmentioning

confidence: 65%

“…In earlier studies of ours we have demonstrated that the water peat extract (WPE) possesses agonistic properties with respect to the a 2 −adrenergic− and D 2 −dopamine receptors [2]. These ef− fects of water peat extract are due to the water−soluble compo− nents of the humic acids contained in peat [4].…”

Section: Abstract Mud´peat´curative Mud´humic Substances´a 2 −Adrenementioning

confidence: 80%

“…The results of prolonged treatment with water peat extract and water mud extract on SCA of SMS are also analogous. After pro− longed effects of water peat extract, we registered 100 % inhibi− tion of the reactivity of the a 2 −adrenergic receptors and reduc− tion of those of the D 2 −dopamine−receptors, also up to 20 % of the initial excitatory effect of the D 2 −agonist Quinpriole [2]. The effect of water mud extract on the a 2 −adrenergic receptors is more difficult to be characterised, because their inactivation oc− curs very quickly ± for up to 40 minutes in the case of treatment with 75 ml water mud extract (in 20 ml organ bath) and after 20 minutes with prolonged treatment with 300 ml water mud ex− tract.…”

Section: Discussionmentioning

confidence: 97%

“…In addition to the effect of heat during the use of mud in clinical practice, some sources also examine the therapeutic effects due to the substances contained in it, i. e., of the so−called ¹chemical effect" [2]. Thus, for example, the effect of mud cure in gynaeco− logical diseases is attributed to a large extent to substances with estrogen action [3].…”

Section: Abstract Mud´peat´curative Mud´humic Substances´a 2 −Adrenementioning

confidence: 99%

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Action of Water Extract from Pomorie Mud on the Spontaneous Contractile Activity of Smooth-Muscle Strips of Guinea Pig Stomach

Grozeva¹,

Am²,

Sagorchev³

et al. 2005

Phys Rehab Kur Med

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Zusammenfassung Hintergrund: Heiltorf und Heilschlämme werden bei verschie− denen Indikationen in der Klinik erfolgreich angewandet. Unab− hängig von physikalisch−thermischen Wirkungen konnten neue Studien so genannte ¹chemische Wirkungen", bedingt durch die enthaltenen Torf− bzw. Schlamminhaltsstoffe, nachweisen. Diese zeichnen sich durch anregende Wirkungen auf die spontane kon− traktile Aktivität an der glatten Muskulatur aus. Das Ziel der vor− liegenden Arbeit ist es, herauszufinden, inwieweit wässeriger Schlammextrakt eine biologische Aktivität besitzt und inwieweit eine Vergleichbarkeit mit wässerigem Torfextrakt diesbezüglich besteht. Methoden: Die Untersuchungen wurden mit Heil− schlamm aus Pomorie (Bulgarien), wie er aus den dortigen Seen gewonnen wird, durchgeführt. Der fein strukturierte Heil− schlamm hat eine schwarze Farbe und riecht leicht nach Hydro− gensulfat. Die biologische Aktivität wurde in Organbädern an glatten Muskelfasern des Meerschweinchenmagens gemessen. Ergebnisse: Die In−vitro−Versuche zeigen, dass wässeriger Schlammextrakt aus den Seen von Pomorie anregenden Wirkun− gen auf die spontane kontraktile Aktivität glatter Muskelfasern des Meerschweinchenmagens aufweist. Die kontraktile Anre− gung ist durch Huminsubstanzen, die sich im Schlamm befinden, bedingt, die agonistische Wirkungen auf a 2 −Adreno− und D 2 − Dopaminrezeptoren an den glatten Muskelzellen besitzen. Schlussfolgerung: Die erhaltenen Ergebnisse machen klinische Beobachtungen der Anwendung von Heilschlamm verständli− cher und bilden die Grundlage für gezielte klinische Studien, die die Rekrutierung von Labordaten und klinischen Daten zur Heil− schlammtherapie erm−glichen. AbstractPurpose: Peat and mud have been successfully applied for a vari− ety of clinical indications. Quite apart from the physical−thermal effects, new studies point towards the so called ¹chemical ef− fects" of peat/mud containing substances. These effects include a stimulatory response of the spontaneous contractile activity of smooth muscle tissue. The aim of the present work is to study the extent to which the water mud extract possesses biological activity and the extent to which it resembles the properties of water peat extract. Methods: The studies were carried out with curative Pomorie mud from the black layer, with very fine struc− ture, plasticity, black colour and a slight smell of hydrogen sul− phide. The biological activity was examined in organ baths by means of smooth muscle fibres of the stomach of guinea pigs. Results: Experiments in vitro show that the water extract from curative mud from the Pomorie Lake possesses excitatory action on the spontaneous contractile activity of smooth−muscle strips of guinea pig stomach. The contractile activation is due to the hu− mic substances contained in the mud, which have an agonistic action on the a 2 −adrenergic and D 2 −dopamine receptors of the smooth−muscle cells. Conclusions: The results obtained allow to explain better some clinical effects of curative mud and to conduct targeted studies in c...

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Section: Discussionmentioning

confidence: 65%

Section: Abstract Mud´peat´curative Mud´humic Substances´a 2 −Adrenementioning

confidence: 80%

Section: Discussionmentioning

confidence: 97%

Section: Abstract Mud´peat´curative Mud´humic Substances´a 2 −Adrenementioning

confidence: 99%

See 2 more Smart Citations

Action of Water Extract from Pomorie Mud on the Spontaneous Contractile Activity of Smooth-Muscle Strips of Guinea Pig Stomach

Grozeva¹,

Am²,

Sagorchev³

et al. 2005

Phys Rehab Kur Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…In unseren bisherigen Arbeiten konnten wir zeigen, dass wässeriger Torfextrakt (WTE) eine anregende Wirkung auf die spontane kontraktile Aktivität (SKA) glatter Muskelstreifen (GMS) besitzt [4,5]. In unseren bisherigen Arbeiten konnten wir zeigen, dass wässeriger Torfextrakt (WTE) eine anregende Wirkung auf die spontane kontraktile Aktivität (SKA) glatter Muskelstreifen (GMS) besitzt [4,5].…”

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Der Einfluss des initialen Feuchtigkeitsgrades von Torf auf die pharmakologischen Eigenschaften von Badetorf / The influence of the initial humidity of balneological peat on its pharmacological features

Beer¹,

Sagorchev²,

Lukanov³

2005

Biomedizinische Technik/Biomedical Engineering

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The viscosity of balneological peat got special meaning according to its thermical features. Until now, there has been no answer on the question in how far balneological peat, which is prepared with different degrees of humidity, can vary the pharmacological character. Aim of this work was, on the one hand, to examine which initial degree of peat-humidity is necessary to get the wished viscosity in therapy when diluted with water. On the other hand, how far the pharmacological character of balneological is influenced by the initial degree of humidity. From peat, with initial different degrees of humidity, balneological peat is prepared, fulfilling the demands of the Quentin-Test and therefore the necessary consistence for therapy. Here in this work the in-vitro effect of aqueous peat extract (APE) on the spontaneous contractile activity of the smooth muscle fibres of guinea-pig stomachs was examined. The APE used got initial different degrees of humidity. It was found out, that the ability of peat according to a new water-uptake, with a initial humidity under 60%, was clearly reduced. Because of the reduced water content of balneological peat its thermical features were deteriorated. This goes for peat with a humidity factor < 60%. First, with the Quentin-Test, showing the optimal viscosity of peat before medical use, you can also make statements according its ability of maximum uptake of water, meaning the ability taking up water until it becomes gel-like. Second, the results show that the initial humidity of peat got no influence on the pharmacological features.

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Bäder- und Klimaheilkunde

Gutenbrunner¹,

Hildebrandt²,

Bühring³

et al. 2001

Naturheilverfahren Und Unkonventionelle Medizinische Richtungen

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Der Wirkungsmechanismus von wässrigem Torfextrakt auf die spontane kontraktile Aktivität der glatten Muskulatur

Cited by 19 publications

References 0 publications

Action of Water Extract from Pomorie Mud on the Spontaneous Contractile Activity of Smooth-Muscle Strips of Guinea Pig Stomach

Action of Water Extract from Pomorie Mud on the Spontaneous Contractile Activity of Smooth-Muscle Strips of Guinea Pig Stomach

Der Einfluss des initialen Feuchtigkeitsgrades von Torf auf die pharmakologischen Eigenschaften von Badetorf / The influence of the initial humidity of balneological peat on its pharmacological features

Bäder- und Klimaheilkunde

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