Der Wert von Umsatzuntersuchungen mit131J-Humanalbumin für die Klinik

Glaubitt, D.; Klippel, H. G.

doi:10.1007/bf01633366

Cited by 4 publications

(2 citation statements)

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“…The half-life was very short (1.25-1.80 days) compared with the normal 4 days (REGOECZI 1966). The half-life of albumin was also short; this varied between 1.25 and 1.7 days, as against the normal of 8.5-12.5 days (GLAUBITT & KLIPPEL 1967), and there were no differences between the groups in this respect.…”

Section: Coagulation and Fibrinolysis Factors Thrombocyte Count: T H mentioning

confidence: 78%

The Use of¹²⁵I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

Busch

Dahlgren

Jakobson

et al. 1975

Acta Anaesthesiol Scand

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T h e microembolism syndrome occurred in four patients out of a series of 15 patients with multiple injuries who were considered to run a risk of developing this syndrome. These four patients showed signs of fibrin trapping in the lungs, as demonstrated by the use of 1251-labelled fibrinogen and external detection over the lungs. I t is, therefore, considered that this method can be used for diagnosing the microemholism syndrome. The fibrin trapping occurred at the onset of the progressive respiratory insufficiency. The time relation between the uptake of fibrin and the onset of the progressive respiratory insufficiency supports the theory of a causal connection between fibrin and pulmonary damage. Measurements of different coagulation and fibrinolysis factors in the blood were not able to discriminate between patients who developed the microembolism syndrome and those who did not.

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Section: Coagulation and Fibrinolysis Factors Thrombocyte Count: T H mentioning

confidence: 78%

The Use of¹²⁵I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

Busch

Dahlgren

Jakobson

et al. 1975

Acta Anaesthesiol Scand

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“…heparinised blood was determined at daily intervals over a period of three weeks. The autologous albumins were produced by the same fractionation procedure as the normal homologous HSA and labelled with 131:-iodine (Berson et at., 1953;Glaubitt and Rippel, 1967). Autologous and homologous albumin fractions were compared prior to an administration by radiochromatography.…”

Section: Methodsmentioning

confidence: 99%

Elimination rate of human serum albumin in paraplegic patients

et al. 1974

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PREVIOUS studies (Lob et at., (1971)) have shown that blood volumes of paraplegics, which are measured by the R-I25-IHSA-method, may result in unreliable values because the elimination rate of homologous human serum albumin is often in creased in these patients. It can be speculated on one hand that the increased elimination rate might be the result of an elevated catabolism of radio-iodinated human serum albumin; on the other hand immunological mechanisms could be the cause, i.e. a developing clinical incompatibility to homologous human serum albumin. With the following investigations it should be elucidated whether or not immune reactions are responsible for the high elimination of human serum albumin in paraplegic patients. PATIENTS AND METHODSThe investigations were done in 24 male and six female paraplegic patients of ages between 18 and 60 years; the results were compared with those of ten normal healthy volunteers. The paraplegic lesions of the patients were at least two weeks old, with a maximum of 20 years. Six patients had lumber spine lesions, II thoracic spine and 13 cervical spine lesions. Twenty-four patients were completely paralysed and six patients incompletely paralysed.The elimination rate of human serum albumin (per cent/hour) was measured with I25-iodine labelled homologous human serum albumin (Fa. Buchler + Co, specific activity 10 /LCi./mg.). Before applying radio-active labelled human serum albumin the thyroid gland was blocked with Endojodin (R) (Fa. Bayer) in order to prevent a selective storage of radio-active iodine in this organ. After the intravenous application of IOO /LCi. R-I25-IHSA the radio-activity was measured in 1 m!. of heparinised blood samples at time intervals of I, 5, 10, 20, 30 and 60 minutes.Furthermore, the body weight, the hematocrit, the erythrocyte sedimentation rate (ESR), the osmolarity, the colloid osmotic pressure, the total serum protein and the serum electrophoresis were controlled.In five patients the disappearance rate of homologous R-I25-IHSA was compared with that of autologous 131 -J human serum albumin according to the method of the immune elimination technique . For this purpose the radio-activity in I m!. heparinised blood was determined at daily intervals over a period of three weeks. The autologous albumins were produced by the same fractionation procedure as the normal homologous HSA and labelled with 131:-iodine (Berson et at., 1953;Glaubitt and Rippel, 1967). Autologous and homologous albumin fractions were compared prior to an administration by radiochromatography.13 9

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Verhalten von 125-J-Albumin im Intravasalraum von Querschnittsgelähmten

Ring

Seifert

Lob

et al. 1974

Chirurgisches Forum ’74

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Der Wert von Umsatzuntersuchungen mit131J-Humanalbumin für die Klinik

Cited by 4 publications

References 1 publication

The Use of¹²⁵I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

The Use of¹²⁵I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

Elimination rate of human serum albumin in paraplegic patients

Verhalten von 125-J-Albumin im Intravasalraum von Querschnittsgelähmten

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Der Wert von Umsatzuntersuchungen mit131J-Humanalbumin für die Klinik

Cited by 4 publications

References 1 publication

The Use of125I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

The Use of125I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

Elimination rate of human serum albumin in paraplegic patients

Verhalten von 125-J-Albumin im Intravasalraum von Querschnittsgelähmten

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The Use of¹²⁵I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*

The Use of¹²⁵I‐labelled Fibrinogen for Determination of Fibrin Trapping in the Lungs in Patients Developing the Microembolism Syndrome*