Der Wasser- und Elektrolytgehalt von Erythrocyten bei arterieller Hypertonie

Losse, H; Wehmeyer, H; Wessels, F

doi:10.1007/bf01483466

Cited by 154 publications

(28 citation statements)

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“…28 Increased intracellular sodium content and decreased activity of the Na + , K + -ATPase enzyme have been proposed as explanations for essential hypertension 29 -30 and have also been found in the offspring of such patients. 29 - 31 -32 The positive correlation between GGT and BP is in accordance with other surveys of alcohol consumption and BP.…”

Section: Discussionsupporting

confidence: 82%

“…This may also indicate that alcohol is one of the main causative factor in the establishment of definite hypertension in predisposed individuals. Such predisposition could be the increased intracellular sodium content, which is found especially in male offspring of established hypertensive patients, 29 " 32 in whom significant correlations between GGT and BP were also found. 33 The results of our present analysis indicate that COHb%, GGT, A/I weight, and HR, independent of each other and in combination, are factors that affect BP.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Henningsen¹,

Janzon²,

Trell³

1983

Hypertension

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SUMMARY Carboxyhemoglobin (COHb%) and gamma-glutamyl-transferase (GGT) are indicators of tobacco and alcohol consumption; similarly, body weight broadly reflects dietary habits. Relationships between COHb%, GGT, relative body weight, heart rate and blood pressure were studied in 242 48-year-old men attending a general health screening program in Malmo, Sweden. All were without treatment for high blood pressure. Positive correlations were found between blood pressure and body weight, GGT, and pulse, and a reciprocal correlation between blood pressure and COHb%. Use of objective markers for known or suspected risk factors, such as alcohol consumption, smoking, or overweight, were studied to elucidate their usefulness for further prospective studies. (Hypertension 5: 560-563, 1983) KEY WORDS • hypertension • multi-variate analysis • risk factors A RTERIAL hypertension constitutes one of the most important risk factors for cardiovascular morbidity and mortality.1 -2 One of the major aims in several population screening trials has therefore been measurement of blood pressure (BP), with subsequent treatment of individuals with consistently elevated levels. 34 Several factors have been shown to covary with BP, namely, heredity, 5 body weight, 6 -7 salt intake, 8 age, 5 -8 and alcohol consumption.79 " 13 However, smoking and potassium intake seem to be inversely related to BP.914 -' 5 Thus, many exogenous factors may be of pathogenetic and pathophysiologic, as well as methodological, importance to the BP levels recorded, reproducibility, predictive value, clinical interpretation, and resulting treatment.Although body weight at least partly reflects dietary habits in the population, it is usually more difficult to get a reliable history of alcohol consumption, at least in individuals with high consumption levels.' 6 Recent studies tend to indicate a linear relationship between BP and alcohol consumption 7 9~13 and BP and gammaglutamyl-transferase (GGT), 18 " 21 although a flattened relationship has been suggested" after a consumption level of 180 g/week.In a recent statistical evaluation of the relationship between alcohol intake and BP, 12 it was suggested that the individual's "immediate" (24-hour) intake was better correlated to the BP. However, others have found good correlation between BP level and amount of alcohol consumed over several weeks and up to 3 months."-' 3 In our ongoing preventive study 22 of men with persistent hypertension, we found that the higher the GGT level the higher the incidence of moderate-tosevere hypertension; this could also indicate a longer acting effect of high alcohol consumption. Carboxyhemoglobin (CoHB%) is today frequently used for the short-term and objective assessment of tobacco consumption. 23The aim of the present study was to evaluate univariate and multivariate correlations between BP, COHB%, relative bodyweight, GGT, and heart rate in a random subsample of untreated healthy middle-aged (48-year-old) men, and to assess how much of the variability in the blood pressure meas...

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Henningsen¹,

Janzon²,

Trell³

1983

Hypertension

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“…The rate constants of sodium efflux measured in 10 pairs of rats (see Figure 1), while higher than in humans, showed similar differences between the normotensive and hypertensive animals. For uninhibited efflux, the rate constant was 1.513 ± 0.041 hr" 1 in WKY and 1.657 ± 0.038 hr" 1 As seen in Figure 1, the relative inhibition of sodium efflux by ouabain was less in rats than in humans. This phenomenon, related to the well-known resistance of the rat to the effect of ouabain, caused our results of ouabain-sensitive component to be an underestimate, and those of ouabain-resistant and ouabain-and-furosemide resistant components to be an overestimate, of values that would be obtained under more complete inhibition of the sodium-potassium pump.…”

Section: Resultsmentioning

confidence: 86%

Erythrocyte membrane transport in hypertensive humans and rats. Effect of sodium depletion and excess.

Feig¹,

Mitchell²,

Boylan³

1985

Hypertension

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SUMMARY Sodium transport by erythrocyte membranes was studied in hypertensive and normotensive humans and in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The rate constants of sodium efflux were increased in both hypertensive humans and rats, and this increase was due mostly to an increase in the ouabain-resistant component of efflux. Both the furosemide-sensitive and furosemide-resistant components of efflux were increased. The ouabainsensitive efflux was also increased, as confirmed by the ouabain-sensitive rubidium influx in rats. In rats, the intracellular sodium content was also increased in the SHR with respect to the WKY. The transport abnormalities of red cell membrane associated with hypertension were similar in humans and rats. In rats, sodium depletion failed to affect the transport abnormality, while sodium load made the difference in transport between SHR and WKY undetectable. Cross-incubation experiments, using plasma and erythrocytes of WKY and SHR, are more suggestive of a flux abnormality that is intrinsic to the cell membrane than of one that is humoral in nature. (Hypertension 7: 423-429, 1985) KEY WORDS • sodium-potassium pump • sodium-potassium cotransport • sodium leak spontaneously hypertensive rats • intracellular cation content M ORE than 2 decades ago, Losse et al.

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“…Most of the recently published results are given in Table VII of the paper by Valberg, Holt, Paulson, and Szivek (3) and need not be duplicated here. Part of the variation of the reported results can be attributed to one or more of the following factors: derivation of RBC potassium concentration from measurement of whole blood and plasma potassium concentrations (4, 5); failure to allow for plasma trapped in the red cell column (6); the use of hospitalized patients as normal control subjects, particularly if some are anemic (7,8); and the use of a part only of the packed cell column for potassium estimation (3), since young cells at the top of the column contain more potassium than older cells at the bottom (9).…”

Section: Discussionmentioning

confidence: 99%

The sodium, potassium, and water contents of red blood cells of healthy human adults

1969

Cryobiology

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Der Wasser- und Elektrolytgehalt von Erythrocyten bei arterieller Hypertonie

Cited by 154 publications

References 10 publications

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Erythrocyte membrane transport in hypertensive humans and rats. Effect of sodium depletion and excess.

The sodium, potassium, and water contents of red blood cells of healthy human adults

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