Der Saphenusperforatorlappen

Winkel, R.; Tajsic, Nenad B.; Husum, Hans; Schlageter, M; Hanebuth, G; Hoffmann, R.

doi:10.1007/s00064-012-0198-z

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…The ancient Mesopotamian, Egyptian, Greek, Roman, Indian, and Chinese physicians practiced bloodletting and often used the application of leeches to treat diseases until the practice reached its height in the 1800s. The use of leeches continues to the present following the Food and Drug Administration-approved use of Hirudo medicinalis in modern medicine [2, 3]. The anticoagulant hirudin identified from leech saliva can help relieve venous insufficiency in skin and reattachment surgery [2, 3].…”

Section: Historical Perspectivesmentioning

confidence: 99%

“…The use of leeches continues to the present following the Food and Drug Administration-approved use of Hirudo medicinalis in modern medicine [2, 3]. The anticoagulant hirudin identified from leech saliva can help relieve venous insufficiency in skin and reattachment surgery [2, 3]. Despite keen medical interest in blood over the ages, the crucial cellular components that contribute to clot formation were not readily identified.…”

Section: Historical Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Platelets and cancer: a casual or causal relationship: revisited

Menter

Tucker

Kopetz

et al. 2014

Cancer Metastasis Rev

277

256

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Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The physiologic demand, presence of disease such as cancer, or drug effects can regulate the production circulating platelets. Platelet biology is essential to hemostasis, vascular integrity, angiogenesis, inflammation, innate immunity, wound healing, and cancer biology. The most critical biological platelet response is serving as “First Responders” during the wounding process. The exposure of extracellular matrix proteins and intracellular components occurs after wounding. Numerous platelet receptors recognize matrix proteins that trigger platelet activation, adhesion, aggregation, and stabilization. Once activated, platelets change shape and degranulate to release growth factors and bioactive lipids into the blood stream. This cyclic process recruits and aggregates platelets along with thrombogenesis. This process facilitates wound closure or can recognize circulating pathologic bodies. Cancer cell entry into the blood stream triggers platelet-mediated recognition and is amplified by cell surface receptors, cellular products, extracellular factors, and immune cells. In some cases, these interactions suppress immune recognition and elimination of cancer cells or promote arrest at the endothelium, or entrapment in the microvasculature, and survival. This supports survival and spread of cancer cells and the establishment of secondary lesions to serve as important targets for prevention and therapy.

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Section: Historical Perspectivesmentioning

confidence: 99%

Section: Historical Perspectivesmentioning

confidence: 99%

Platelets and cancer: a casual or causal relationship: revisited

Menter

Tucker

Kopetz

et al. 2014

Cancer Metastasis Rev

277

256

View full text Add to dashboard Cite

show abstract

“…remains to be answered by large-scale studies. 29 Only one research work closely relating to this study is that by Winkel et al, 30 but they used the pedicled saphenous perforator flap in the distal third leg. This is the first clinical series on the SAPP flaps.…”

Section: Discussionmentioning

confidence: 99%

Saphenous Artery Perforator/Propeller Flap in the Reconstruction of Perigenual Soft Tissue Defects

Balakrishnan

Narayanan

Janardhanam

2019

Indian J Plast Surg

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Introduction In this article, we investigate the saphenous artery perforator propeller flap for the reconstruction of perigenual defects. We describe the anatomy of the saphenous artery and the method of raising a perforator propeller flap based on our study and early clinical experience. Aim To assess the effectiveness of the saphenous artery perforator propeller flap in the reconstruction of perigenual defects. Materials and Methods A preliminary cadaver dissection and injection study was conducted to discern the anatomical details of the perforator system of the saphenous vessel in 35 cadaveric specimens in 18 fresh cadavers. From March 2016 to March 2018, 16 clinical cases (5 females and 11 males, in the average age group of 33.5 years) with perigenual defects were reconstructed with saphenous artery perforator propeller flap. They were followed up for an average period of 12.5 months. Results Cadaver study established anterior sartorial perforators as the dominant system of the saphenous vessel and brought to the forefront the type 2 blood supply of the saphenous nerve. All patients had well-settled flaps at the end of the follow-up period, with good return of knee function. Conclusion Saphenous artery perforator propeller flap is a viable option for the reconstruction of defects around the knee joint. Level of Evidence Type V, therapeutic study.

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“…Hierzu können in seltenen Fällen gestielte fasziokutane Lappen, wie z. B. ein Saphenuslappen, verwendet werden [31].…”

Section: Einzeitige Offene Reposition Und Innere Fixationunclassified

Pilonfrakturen

2015

Self Cite

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Pilon fractures are uncommon, representing approximately 5-10 % of all lower limb fractures. Pilon fractures are often associated with serious soft tissue injuries resulting in initial external fixation followed by internal fixation once the condition of the soft tissues has improved. Articular distal fractures of the tibia are classified as B3, C1, C2 and C3 fractures according to the AO Classification. Pilon fractures are usually the result of a high energy trauma. A low energy trauma such as a twisting injury of the ankle can also lead to a pilon fracture. Such low energy mechanisms of injury are rarely associated with significant soft tissue injury and can be immediately fixated internally. Pilon fractures are often associated with an unsatisfactory healing response. This is a result of a combination of factors including the severity of the trauma, the extent of the initial soft tissue injury and the accuracy of the articular surface reconstruction.

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Der Saphenusperforatorlappen

Cited by 5 publications

References 21 publications

Platelets and cancer: a casual or causal relationship: revisited

Platelets and cancer: a casual or causal relationship: revisited

Saphenous Artery Perforator/Propeller Flap in the Reconstruction of Perigenual Soft Tissue Defects

Pilonfrakturen

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