Der potentielle Diabetes (sog. Prädiabetes)

Jahnke, K.; Daweke, H.; Schilling, W.; Rüenauver, R.; Oberdisse, K.

doi:10.1007/978-3-642-96034-5_140

Cited by 2 publications

(1 citation statement)

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“…We have previously focused attention on the possibility of a delayed and diminished insulin-releasing capacity of the beta-cells of the pancreas being primary event in the pathogencsis o% genetic digbetes (Cerasi and Luft, 1967e). This has also been discussed by other authors (Jahnke et al, 1966;Colwell and Lein, 1967;Shima and Foa, 1967;Daweke et al 1968). The studies from which the hypothesis was derived were performed on adult subjects.…”

Section: Discussionsupporting

confidence: 77%

The occurrence of low insulin response to glucose infusion in children

Cerasi

Luft

1970

Diabetologia

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Insulin response to glucose infusion was studied in 42 children with a normal intravenous glucose tolerance, 7-16 years of age. The majority of these children had at least one first degree relative with diabetes mellitus. Low and delayed insulin response similar to the one found in 15-20% of healthy adult subjects also occurred in 15-20 per cent of the children in this material. These findings support our previous suggestion that the low and delayed insulin response to glucose is probably genetically determined. L' existence de r@onse insulinique rdduite g la perfusion de glucose chez l'enfant Rdsumd. La rdponse insulinique ~ la perfusion de glucose a 4t4 6tudide chez 42 enfants ggds de 7 g 16 ans et ayant un test de toldrance au glucose normal. Chez la plupart des enfants au moins un des parents ou frgres et soeurs avait le diab6te. Une r@onse insulinique rdduite et retard@, similaire ~ celle observde chez 15 ~ 20% des adultes on bonne santd, a 6t4 d6montrde ehez 7 enfants sur les 42. Ces rdsultats eonfirment notre suggestion que ce type de rdponse insulinique rdduite et retardde est probablement ddtermin6e par des faeteurs hdrdditaires. 19as Vorkorame~ yon verringerter Insulinausschi~ttung nach Glukoseinfusion bei K~ndern Zusammenfassung. Die Insulinausschiittung nach Glucoseinfusion wurde bei 42 Kindern, 7-16 Jahre alt, mit normaler intraven6sen Glucosetoleranz untersucht. Die Mehrzahl dieser Kinder hatte einen diabeteskranken Eltern-oder Geschwisterteil. Nine verz6gerte nnd verringerte Insulinfreisetzung, i~hnlich denen, die bei 15-20~o yon gesunden Erwachsenen gefunden worden waren, war bei 7 yon 42 Kindern zu sehen. Dieser Befund stiitzt unsere friihere Ansich~, dal3 die verz6gerte und verringerte Insulinansschiittung bei Hyperglyk/imie wahrscheinlich genetisch bedingt ist.

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Section: Discussionsupporting

confidence: 77%