Der maligne Knochenschmerz

Kopf, Andreas

doi:10.1007/s001010050747

Cited by 2 publications

(1 citation statement)

References 66 publications

(33 reference statements)

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“…It has been identified as the component in bovine serum that is necessary for maintaining neurons in serum-free media (2). Health conditions such as immune function (5), viral infection (6), reproduction problems (7), mood disorders (8), skeletal myopathy and macrocytosis (9), seizures (10), cancer (11), and cardiovascular diseases (12) have been linked to selenium deficiency. These also include an increased severity of infectious diseases such as Keshan disease, an endemic cardiomyopathy, and Kashin-Beck disease, a deforming arthritis (6).…”

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confidence: 99%

Selenium deficiency increases susceptibility to glutamate‐induced excitotoxicity

et al. 2002

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Excitotoxic brain lesions, such as stroke and epilepsy, lead to increasing destruction of neurons hours after the insult. The deadly cascade of events involves detrimental actions by free radicals and the activation of proapoptotic transcription factors, which finally result in neuronal destruction. Here, we provide direct evidence that the nutritionally essential trace element selenium has a pivotal role in neuronal susceptibility to excitotoxic lesions. First, we observed in neuronal cell cultures that addition of selenium in the form of selenite within the physiological range protects against excitotoxic insults and even attenuates primary damage. The neuroprotective effect of selenium is not directly mediated via antioxidative effects of selenite but requires de novo protein synthesis. Gel shift analysis demonstrates that this effect is connected to the inhibition of glutamate-induced NF-kappaB and AP-1 activation. Furthermore, we provide evidence that selenium deficiency in vivo results in a massive increase in susceptibility to kainate-induced seizures and cell loss. These findings indicate the importance of selenium for prevention and therapy of excitotoxic brain damage.

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