Der Kreislauf in Hypothermie

Brendel, W.; Albers, C.; Usinger, W.

doi:10.1007/bf00370276

Cited by 38 publications

(10 citation statements)

References 25 publications

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“…A similar result was reported by Prec et al [1949], who found increased cardiac output in 10 out of 12 anaesthetized dogs at a Tre of 3500, reaching as much as 126 per cent of the basal output. Brendel et al [1958] reported a similar finding for the cardiac output in 13 dogs whose Tre had been reduced to 3500 in an ice water bath; output in these animals was 116 per cent of that measured at Tre 3800. However, all these findings were contrary to that obtained by Brendel et al [1958] in 5 dogs whose Tre had been reduced to 3500 in a cold room, in that the cardiac output was reduced by 22 per cent of that measured at Tre of 3800.…”

Section: Discussionsupporting

confidence: 58%

“…Heart rate has been reported to fall linearly with decreasing body temperature in anaesthetized dogs [Brendel et al, 1958;Prec et al, 1949]. There was a decrease in heart rate in our hypothermic sheep but only in relation to the elevated rates reached prior to this during exposure.…”

Section: Discussionmentioning

confidence: 41%

“…Prec et al, 1949], or the rates of cooling [e.g. Brendel et al, 1958]. By interpolation cardiac output at Tre of 3500 in five out of six of our sheep was elevated relative to output in the same animals when they were warm and dry.…”

Section: Discussionmentioning

confidence: 95%

“…The reduction in mean arterial blood pressure as cardiac output drops in hypothermic dogs has been recorded by Brendel et al [1958]. There were individuals, however, among these animals where arterial blood pressure rose, for a time, when cardiac output was decreasing [Brendel et al, 1958].…”

Section: Discussionmentioning

confidence: 99%

“…The majority of results are confounded by anaesthesia of the subjects [Thauer, 1965] and the rates at which anaesthetized subjects were cooled [Brendel et al, 1958]. Data of other indices of cardiac physiology in cold-stressed sheep are also fragmentary.…”

mentioning

confidence: 99%

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Cardiovascular Parameters in Shorn Sheep Prior to and During Their Exposure to a Cold, Wet Environment

Panaretto¹,

Vickery²

1971

Exp Physiol

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When shorn sheep were exposed to ambient temperatures of 30C and the residual fleece was wetted, heart rate and cardiac output increased substantially above levels measured during a control period at 250C. With continued cold exposure and wetting the sheep become hypothermic and heart rate and cardiac output decreased. In most sheep at rectal temperature <32°C cardiac output had fallen below control values while heart rate remained above control. In a minority of hypothermic sheep cardiac output remained above control rates.Our interest in physiological events that occur during cold-stress in sheep originated from deaths of sheep from this cause after shearing in Australia. Hutchinson [1968] reviewed losses suffered by newly-shorn sheep that are exposed to cold, wet conditions and he concluded that approximately one million sheep died annually from cold exposure.Few data on cardiac output during cold exposure and hypothermia have been collected in conscious animals. The majority of results are confounded by anaesthesia of the subjects [Thauer, 1965] and the rates at which anaesthetized subjects were cooled [Brendel et al., 1958]. Data of other indices of cardiac physiology in cold-stressed sheep are also fragmentary. Hutchinson et al. [1960] reported elevated heart rates in sheep exposed to a cold, windy environment that reduced their rectal temperature (Tre) to approximately 37*4°C. In many other studies on newly-shorn sheep, cold exposure has been transient and measurements of body temperature and heart rate have not been concurrent [Slee, 1966; Slee and Sykes, 1967;Sykes and Slee, 1969].We have, therefore, studied cardiovascular parameters in newly-shorn sheep held at a control temperature of 250C and repeated the measurements when the sheep were exposed to a cold (3°C), wet environment. Endocrinological aspects of these experiments are reported elsewhere [Panaretto and Vickery, 1970]. METHODSThe sheep and their pre-experimental treatment. Six adult Merino ewes and one wether (no. 4) each weighing about 30 kg were used; they were accustomed to the presence of the observers. Each animal was given 400 g daily of a mixture of equal parts of lucerne chaff and oats which was sufficient to maintain body weight during the 4-8 weeks prior to the experiments. The same quantity of feed was given during cold exposure.The sheep were shorn and a femoral arterial catheter (clear vinyl, i.d. 1*5 mm, 101

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 41%