Der konnatale Hydrozephalus - Präoperative Abklärungen und intraoperative Befunde beim konnatalen Hydrozephalus

Illi, O. E.; Pochon, J. P.

doi:10.1055/s-2008-1043453

Cited by 1 publication

(1 citation statement)

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“…Similar findings were reported by other authors. An infectious origin, such as intrauterine toxoplasmosis, was rendered responsible in 3-9 % of congenital hydrocephalus (2,8,11,12,23,27), an aqueductal stenosis in 300/0 ofthe cases (14).…”

Section: Subgroup Children Without Detectable Disturbing Influelues (mentioning

confidence: 99%

Catamnestic Investigations in Children with Congenital Hydrocephalus

Angerpointner

Pockrandt²,

Schroer³

1990

Eur J Pediatr Surg

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Catamnestic investigations on the course of pregnancy, family history and genetics were carried out in 141 children suffering from congenital hydrocephalus. The results were compared with those obtained from a group of non-malformed controls investigated by the same criteria. There was a considerably higher incidence of pregnancy disturbances (i.e. diseases, drugs, haemorrhage etc.) in mothers who later gave birth to a child with congenital hydrocephalus, than mothers of the control group (congenital hydrocephalus: 61.3% vs. controls: 30.1%). This high incidence of pregnancy disturbances could be particularly referred to a sevenfold increased rate of diseases and a fourfold increased rate of drug intake during the first trimester. There was also a higher rate of malformed relatives in children with congenital hydrocephalus (16.7%) than in controls (6.4%); not only were malformations of the central nervous system found to be increased but also malformations of other organ systems in relatives. This is interpreted as a hint not only at genetic influences but also at a generally higher incidence of malformations in a relatively small group of persons. Calculated figures of recurrence risk were in accordance with empirical data used in genetic counselling.

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