Der katalytische enantioselektive Aufbau von Molekülen mit quartären Kohlenstoff-Stereozentren

Corey, E. J.; Guzmán-Pérez, Angel

doi:10.1002/(sici)1521-3757(19980216)110:4<402::aid-ange402>3.0.co;2-6

Cited by 325 publications

(1 citation statement)

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“…In the area of asymmetric catalysis, the formation of quaternary carbon stereocenters represents the most challenging goal to achieve both in acyclic or cyclic molecules and of increasing difficulty when targeting spirocyclic compounds. [1] Indeed, when developing a new asymmetric catalytic method to install tertiary stereocenters, the final experiments to assess the "higher and added" value of the protocol focus on forging a quaternary one with the same efficiency.…”

Section: Introductionmentioning

confidence: 99%

From Three‐ to Six‐Membered Heterocycles Bearing a Quaternary Stereocenter: an Asymmetric Organocatalytic Approach

Lattanzi

2023

The Chemical Record

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The development of procedures useful to form quaternary stereocenters stands out as a highly challenging task in asymmetric synthesis. With the arrival of organocatalysis, different activation strategies became available to pursue this intriguing target, thus leading to notable advancements of the area. In this account, our achievements, spanning over a decade, on asymmetric methodologies to access novel three‐, five‐, six‐membered heterocycles, including spiro compounds bearing quaternary stereocenters, will be highlighted. The Michael addition reaction has been often exploited to trigger cascade reactions, using organocatalysts mostly derived from Cinchona alkaloids, and operating under non‐covalent activation of the reagents. Further manipulations of the enantioenriched heterocycles, attested them as useful compounds to prepare functionalized building blocks.

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Section: Introductionmentioning

confidence: 99%