Der interhemispherielle Transfer und seine Relevanz in der Neurologie und Psychiatrie

Richthofen, Sita von; Tabrizian, S.; Grabe, H. J.; Meyer, B.-U.

doi:10.1055/s-2003-42189

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…Three studies reported reduced FA values in the corpus callosum. The corpus callosum is the most important connection between the cortical areas of the brain in both hemispheres, connecting the fibers of motor, sensory and visual cortices ( 81 ). Studies have found that patients with acute plateau brain edema may present with multiple microhemorrhages along the corpus callosum ( 46 , 82 ) and iron heme deposits ( 83 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis

et al. 2023

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PurposeTo conduct a systematic review and meta-analysis of observational studies of brain MRI, this paper assesses the effects of long-term exposure to high-altitude on brain structures in healthy people.MethodsObservational studies related to high-altitude, brain and MRI were systematically searched based on data retrieved from PubMed, Embase and Cochrane Library. The timescale for collecting literature was from the establishment of the databases to 2023. NoteExpress 3.2 was used to manage the literature. Two investigators performed literature screening and data extraction based on inclusion criteria, exclusion criteria, and literature quality. The quality of the literature was assessed using the NOS Scale. Finally, meta-analysis of included studies was performed using Reviewer Manager 5.3.ResultsInitially, 3,626 articles were retrieved. After screening, 16 articles (n = 756 participants) were included in the systematic review, and meta-analysis was performed on 6 articles (n = 350 participants). The overall quality of the included articles was at medium level, with a mean NOS score of 5.62. The results of meta-analysis showed that the differences between the HA group and LA group were not statistically significant, in total GM volume (MD: −0.60, 95% CI: −16.78 to 15.58, P = 0.94), WM volume (MD: 3.05, 95% CI: −15.72 to 21.81, P = 0.75) and CSF volume (MD: 5.00, 95% CI: −11.10 to 21.09, P = 0.54).The differences between HA and LA in FA values of frontotemporal lobes were not statistically significant: right frontal lobe (MD: −0.02, 95% CI: −0.07 to 0.03, P = 0.38), left frontal lobe (MD: 0.01, 95% CI: −0.02 to 0.04, P = 0.65), right temporal lobe (MD: −0.00, 95% CI: −0.03 to 0.02, P = 0.78) and left temporal lobe (MD: −0.01, 95% CI: −0.04 to 0.02, P = 0.62). However, there were significant differences in GM volume, GM density and FA values in local brain regions between HA group and LA group.ConclusionCompared with LA area, there were no significant differences in total GM, WM and CSF volumes in healthy people living at high-altitude area for long-term, while there were significant differences in GM volume and FA values in local brain regions. Long-term exposure to high-altitude area caused the adaptive structural changes in local brain regions. Since heterogeneity existed between the studies, further studies are needed to uncover the effects of high-altitude on brain of healthy people.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023403491.

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Section: Discussionmentioning

confidence: 99%

Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis

et al. 2023

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Long‐term course and mutational spectrum of spatacsin‐linked spastic paraplegia

Hehr

Bauer

Winner

et al. 2007

Annals of Neurology

112

121

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Cortical excitability in schizophrenia

2007

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Abnormalities in brain plasticity, including abnormal information processing by disturbed cortical inhibition and facilitation in schizophrenia, have been described several times in the past. Transcranial magnetic stimulation (TMS) provides a neurophysiological technique for the measurement of cortical excitability, especially of the motoneural system. With TMS it is possible to explore important aspects of the pathophysiological mechanisms underlying schizophrenia using recently developed paradigms (paired pulse method, cortical silent period). This review summarizes the results of available diagnostic TMS studies in schizophrenia. Studies investigating the efficacy of therapeutic repetitive magnetic stimulation in patients with treatment resistant hallucinations or predominantly negative symptoms were not considered. The reviewed studies support the assumption of reduced cortical inhibition, probably caused by GABAergic deficit, in schizophrenia. Factors influencing the study results, the limitations of this promising technique in schizophrenia, and further research options are discussed.

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Der interhemispherielle Transfer und seine Relevanz in der Neurologie und Psychiatrie

Cited by 5 publications

References 18 publications

Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis

Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis

Long‐term course and mutational spectrum of spatacsin‐linked spastic paraplegia

Cortical excitability in schizophrenia

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