Der Einfluß des Serums Allergischer auf Trichophytonpilze

Jessner, Max; Hoffmann, Heinrich

doi:10.1007/bf01845243

Cited by 28 publications

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“…Some of these sera were reported to have antidermatophyte properties. For example, sera of patients with deep-seated trichophytosis decreased the virulence of the dermatophyte in guinea pigs and inhibited its growth on culture media (Jessner and Hoffmann, 1924). When sera from patients with dermatophytids were added in an 8% concentration to Sabouraud's medium and the medium was then inoculated with the fungus isolated from the primary focus, growth was inhibited.…”

Section: Serum Factorsmentioning

confidence: 99%

Immunopathology

1983

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Section: Serum Factorsmentioning

confidence: 99%

Immunopathology

1983

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“…In general, precipitating or complement-fixing antibodies have been detected in sera of patients with (1) chronic or recurrent infections, especially due to T. rubrum, (2) highly inflammatory infections at the height of infection, or (3) with secondary dermatophytid eruptions (Pepys et al, 1959;Sutter, 1917;Blumenthal and von Haupt, 1922;Kuroda, 1958;Jessner and Hoffman, 1924;Ayres and Anderson, 1934). These antibodies usually cross-reacted with antigens of other species of dermatophytes (Tomomatsu, 1962;.…”

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confidence: 96%

Immunology of Surface Fungi Dermatophytes

Grappel

1981

Immunology of Human Infection

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“…Thus, conalbumin, lactalbumin, transferrin, and other iron-binding proteins may inhibit growth of microorganisms by depriving them of essential iron. The inhibitory effects of serum specifically on dermatophytes were observed as early as 1923 (8). Transferrin, a normal serum iron-binding protein, was recently identified as the serum dermatophyte inhibitory factor (11).…”

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confidence: 99%

Effects of deferoxamine methanesulfonate onTrichophyton mentagrophytes

1979

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Defcroxamine methanesulfonate (Desferal R.), an iron chelator, inhibited germ tube formation and growth of Trichophyton mentagrophytes in a microculture-assay. A 50 ;o reduction of germ tube formation required Desferal at 5 mg/ml and a 50 o~ reduction of growth required 1.5 mg/ml. Growth was almost completely inhibited with 50 and 100 mg/ml. Also, Desferal at 100mg/ml inhibited further elongation when added to short hyphae {1I and 21#m), but showed less inhibitory effects when added to long hyphae (64/~m). Iron (133/~g/ml) reversed the inhibition of growth produced by incubating spores with Desferal at 5 mg/mI, providing iron was added before 72h incubation. Desferal at 100mg/ml decreased viability of activated spores incubated fi)r 3 days at 30 ~-'C, hut did not decrease viability of spores incubated for 3 days at 4 °C. The growth inhibitory effect of Desferal and transferrin were compared. Transferrin was inhibitory at low molarities (0.001 to 1.0raM), while Dest~ral was inhibitory only at higher molarities (greater than 1 raM). Desferal (0-05raM) also reversed the inhibition expected with 0.05 mM transferrin. These findings indicate that Desferal and transferrin deprive T. mentagroph),tes of nutritional iron and thus inhibit growth of the fungus. Low concentrations of Desferal can also promote growth in the presence of transferrin.

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Der Einfluß des Serums Allergischer auf Trichophytonpilze

Cited by 28 publications

References 0 publications

Immunopathology

Immunopathology

Immunology of Surface Fungi Dermatophytes

Effects of deferoxamine methanesulfonate onTrichophyton mentagrophytes

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